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ICA 069673 - ≥99%(HPLC), high purity , CAS No.582323-16-8

≥99%(HPLC)

CAS#: 582323-16-8
Formula: C₁₁H₆ClF₂N₃O
Molecular Weight: 269.63
PubChem CID: 10149311

Item Number

I286718

Grouped product items
SKU	Size	Availability	Price
I286718-5mg	5mg	In stock	$82.90
I286718-25mg	25mg	In stock	$307.90
I286718-100mg	100mg	In stock	$973.90

KV7.2/KV7.3 channel opener

Basic Description

Synonyms	582323-16-8 \| ICA 069673 \| ICA-069673 \| ICA069673 \| N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide \| N-(2-chloropyrimidin-5-yl)-3,4-difluorobenzamide \| NCO5DC74G8 \| CHEMBL2047521 \| N-(2-chloropyrimidin-5-yl)-3,4-difluoro-benzamide \| ICA-69673 \| N-(2-chloro-pyrimidin-5-yl)-
Specifications & Purity	≥99%(HPLC)
Biochemical and Physiological Mechanisms	Selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50= 0.69μM). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontane
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SCN5A Tclin Sodium channel protein type V alpha subunit (3462 Activities)

Discover Target: SCN5A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNQ1 Tclin Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) (185 Activities)

Discover Target: KCNQ1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNQ2 Tclin Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) (372 Activities)

Discover Target: KCNQ2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNQ3 Tclin Voltage-gated potassium channel KCNQ3/KCNQ5 (37 Activities)

Discover Target: KCNQ3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-(2-chloropyrimidin-5-yl)-3,4-difluorobenzamide
INCHI	InChI=1S/C11H6ClF2N3O/c12-11-15-4-7(5-16-11)17-10(18)6-1-2-8(13)9(14)3-6/h1-5H,(H,17,18)
InChi Key	IIBSHMFXVWTQSJ-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C=C1C(=O)NC2=CN=C(N=C2)Cl)F)F
Isomeric SMILES	C1=CC(=C(C=C1C(=O)NC2=CN=C(N=C2)Cl)F)F
PubChem CID	10149311
Molecular Weight	269.63

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot Number	Certificate Type	Date	Item
J2130958	Certificate of Analysis	Aug 14, 2024	I286718
J2130959	Certificate of Analysis	Aug 14, 2024	I286718
J2130960	Certificate of Analysis	Aug 14, 2024	I286718

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

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