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ICA 121431 - ≥98%(HPLC), high purity , CAS No.313254-51-2
Potent and selective NaV1.3 and NaV1.1 channel blocker
Basic Description Synonyms F0012-0842 | Oprea1_750763 | 2,2-DIPHENYL-N-{4-[(1,3-THIAZOL-2-YL)SULFAMOYL]PHENYL}ACETAMIDE | BDBM50118516 | BCP28611 | 2,2-DIPHENYL-N-[4-(THIAZOL-2-YLSULFAMOYL)-PHENYL]-ACETAMIDE | 8DE | HY-16787 | MFCD00992334 | Z30538253 | ICA-121431 | NCGC00379252-02 Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50values are 13 and 23 nM respectively). Exhibits up to 1,000 fold selectivity against other TTX-sensitive or resistant sodium channels (IC50values are >10μM for human NaV1.5 and NaV1.8 Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2,2-diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide INCHI InChI=1S/C23H19N3O3S2/c27-22(21(17-7-3-1-4-8-17)18-9-5-2-6-10-18)25-19-11-13-20(14-12-19)31(28,29)26-23-24-15-16-30-23/h1-16,21H,(H,24,26)(H,25,27) InChi Key URSQNPPONHUJDL-UHFFFAOYSA-N Canonical SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CS4 Isomeric SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CS4 WGK Germany 3 PubChem CID 998021 Molecular Weight 449.55
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 44.95, Max Conc. mM: 100
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H319: Causes serious eye irritation
H413: May cause long lasting harmful effects to aquatic life
H302: Harmful if swallowed
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P337+P317: If eye irritation persists: Get medical help.
WGK Germany 3 RIDADR NONHforallmodesoftransport
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