Grouped product items

SKU

Size

Availability

Price

Qty

I648624-1mg

1mg

Available within 8-12 weeks(?)

$180.90

I648624-5mg

5mg

Available within 8-12 weeks(?)

$540.90

I648624-10mg

10mg

Available within 8-12 weeks(?)

$900.90

I648624-50mg

50mg

Available within 8-12 weeks(?)

$2,640.90

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC 50 of 2.1 µM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC 50 of 2.1 µM. In Vitro The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 2.1 µM (Antileishmanial)

Associated Targets(Human)

KCNN1 Tchem Small conductance calcium-activated potassium channel protein 1 (1 Activities)

Discover Target: KCNN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN3 Tchem Small conductance calcium-activated potassium channel protein 3 (3 Activities)

Discover Target: KCNN3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN2 Tchem Small conductance calcium-activated potassium channel protein 2 (2 Activities)

Discover Target: KCNN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN2 Tchem Small conductance calcium-activated potassium channel protein 2 (20 Activities)

Discover Target: KCNN2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNN4 Tchem Intermediate conductance calcium-activated potassium channel protein 4 (87 Activities)

Discover Target: KCNN4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC2A1 Tchem Glucose transporter (14755 Activities)

Discover Target: SLC2A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNN1 Tchem Small conductance calcium-activated potassium channel protein 1 (21 Activities)

Discover Target: KCNN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Huh-7 (12904 Activities)

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MRC5 (9203 Activities)

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HepG2 (196354 Activities)

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KB (17409 Activities)

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MECP2 Tchem Methyl-CpG-binding protein 2 (12 Activities)

Discover Target: MECP2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MBD2 Tchem Methyl-CpG-binding domain protein 2 (8 Activities)

Discover Target: MBD2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Kcnn3 Small conductance calcium-activated potassium channel protein 3 (210 Activities)

Discover Target: Kcnn3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mycobacterium tuberculosis (203094 Activities)

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Trypanosoma brucei brucei (13300 Activities)

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Plasmodium falciparum (966862 Activities)

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Leishmania donovani (89745 Activities)

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Plasmodium yoelii (6656 Activities)

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ht1 Hexose transporter 1 (14071 Activities)

Discover Target: ht1

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Mycobacterium tuberculosis variant bovis BCG (1626 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	N,4-dipyridin-2-yl-1,3-thiazol-2-amine
INCHI	InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)
InChi Key	RYCUBTFYRLAMFA-UHFFFAOYSA-N
Canonical SMILES	C1=CC=NC(=C1)C2=CSC(=N2)NC3=CC=CC=N3
Isomeric SMILES	C1=CC=NC(=C1)C2=CSC(=N2)NC3=CC=CC=N3
PubChem CID	772885
NSC Number	751858
MeSH Entry Terms	N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine
Molecular Weight	254.31

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	DMSO : ≥ 49.5 mg/mL (194.64 mM)

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Wenfu Lin, Yan Huang, Zhenru Li, Jiongshen Pan, Tiansheng Huang, Lili Liang, Yanzhen Tan, Jie Li, Li-Peng Sun, Bai-Ou Guan. (2023) ZIF-90-Derived Porous ZnO Coated Optical Microfiber Interferometer Sensor for Enhanced Humidity Sensing and Breath Monitoring. ACS Applied Materials & Interfaces, 15 (26): (32057–32065). [PMID:37352511]
2. Ting Zhang, Keli Dong, Lan Xiao, Guangcheng Li, Zhanwei Zhang. (2022) Effects of Co-Administration of Icariin and Panax notoginseng Saponins on Intestinal Microbiota and Hippocampal Protein Expression in a Mouse Model of Alzheimer’s Disease. Neuropsychiatric Disease and Treatment, [PMID:33061388]
3. Zhou Mengyang, Guo Min, Shi Xincui, Ma Jie, Wang Shutao, Wu Shuo, Yan Weiqun, Wu Feng, Zhang Peibiao. (2022) Synergistically Promoting Bone Regeneration by Icariin-Incorporated Porous Microcarriers and Decellularized Extracellular Matrix Derived From Bone Marrow Mesenchymal Stem Cells. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35464719]
4. Kun Li, Yingnan Zhang, Junwei Xu, Jingxi Wang, Xuenan Gu, Ping Li, Yubo Fan. (2021) Three-dimensional magnetic fibrous scaffold with icariin expanded by supercritical CO2 for bone tissue engineering under static magnetic field. COMPOSITES PART B-ENGINEERING, 226 (109304). [PMID:]
5. He Qi, Zheng Li, Haijiao Zheng, Qiong Jia. (2021) Carnosine functionalized magnetic metal–organic framework nanocomposites for synergistic enrichment of phosphopeptides. ANALYTICA CHIMICA ACTA, 1157 (338383). [PMID:33832591]
6. Chenxi Yu, Wenyu Zhu, Zhaozhan He, Jin Xu, Fengyan Fang, Ziang Gao, Wenli Ding, Yixiang Wang, Jing Wang, Junqiao Wang, Ao Huang, Aohua Cheng, Yanhui Wei, Shiyun Ai. (2021) ATP-triggered drug release system based on ZIF-90 loaded porous poly(lactic-co-glycolic acid) microspheres. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 615 (126255). [PMID:]
7. Xiaobang Liu, Ting Yue, Kai Qi, Bao Yu Xia, Zhenyu Chen, Yubing Qiu, Xingpeng Guo. (2020) Probe into metal-organic framework membranes fabricated via versatile polydopamine-assisted approach onto metal surfaces as anticorrosion coatings. CORROSION SCIENCE, 177 (108949). [PMID:]
8. Xiaofeng Shen, Pengfei Yu, Hua Chen, Jiangping Wang, Binjie Lu, Xuefeng Cai, Chun Gu, Guoqiang Liang, Donglin Hao, Qihan Ma, Yuwei Li. (2020) Icariin controlled release on a silk fibroin/mesoporous bioactive glass nanoparticles scaffold for promoting stem cell osteogenic differentiation. RSC Advances, 10 (20): (12105-12112). [PMID:35496600]
9. Dan Zhang, Yu Fan, Gaojie Li, Wei Du, Runlong Li, Yiming Liu, Zhixuan Cheng, Jiaqiang Xu. (2020) Biomimetic synthesis of zeolitic imidazolate frameworks and their application in high performance acetone gas sensors. SENSORS AND ACTUATORS B-CHEMICAL, 302 (127187). [PMID:]
10. Xiaoxu Zhao, Hao Zhang, Sheng Xu, Yan Wang. (2019) ZIF-8 membrane synthesized via covalent-assisted seeding on polyimide substrate for pervaporation dehydration. AICHE JOURNAL, 65 (8): (e16620). [PMID:]
11. Haotian Li, Xinran Zhang, Xi Qi, Xu Zhu, Liming Cheng. (2019) Icariin Inhibits Endoplasmic Reticulum Stress-induced Neuronal Apoptosis after Spinal Cord Injury through Modulating the PI3K/AKT Signaling Pathway. International Journal of Biological Sciences, 15 (2): ( 277–286). [PMID:30745820]
12. Yan Dan, He Yu, Ge Yili, Song Gongwu. (2017) Fluorescent Detection of Phosphate in Aqueous Solution Based on Near Infrared Emission Ag2S QDs/Metal − Organic Shell Composite. JOURNAL OF FLUORESCENCE, 27 (1): (227-233). [PMID:27726052]

References

1. Wenfu Lin, Yan Huang, Zhenru Li, Jiongshen Pan, Tiansheng Huang, Lili Liang, Yanzhen Tan, Jie Li, Li-Peng Sun, Bai-Ou Guan. (2023) ZIF-90-Derived Porous ZnO Coated Optical Microfiber Interferometer Sensor for Enhanced Humidity Sensing and Breath Monitoring. ACS Applied Materials & Interfaces, 15 (26): (32057–32065). [PMID:37352511]
2. Ting Zhang, Keli Dong, Lan Xiao, Guangcheng Li, Zhanwei Zhang. (2022) Effects of Co-Administration of Icariin and Panax notoginseng Saponins on Intestinal Microbiota and Hippocampal Protein Expression in a Mouse Model of Alzheimer’s Disease. Neuropsychiatric Disease and Treatment, [PMID:33061388]
3. Zhou Mengyang, Guo Min, Shi Xincui, Ma Jie, Wang Shutao, Wu Shuo, Yan Weiqun, Wu Feng, Zhang Peibiao. (2022) Synergistically Promoting Bone Regeneration by Icariin-Incorporated Porous Microcarriers and Decellularized Extracellular Matrix Derived From Bone Marrow Mesenchymal Stem Cells. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35464719]
4. Kun Li, Yingnan Zhang, Junwei Xu, Jingxi Wang, Xuenan Gu, Ping Li, Yubo Fan. (2021) Three-dimensional magnetic fibrous scaffold with icariin expanded by supercritical CO2 for bone tissue engineering under static magnetic field. COMPOSITES PART B-ENGINEERING, 226 (109304). [PMID:]
5. He Qi, Zheng Li, Haijiao Zheng, Qiong Jia. (2021) Carnosine functionalized magnetic metal–organic framework nanocomposites for synergistic enrichment of phosphopeptides. ANALYTICA CHIMICA ACTA, 1157 (338383). [PMID:33832591]
6. Chenxi Yu, Wenyu Zhu, Zhaozhan He, Jin Xu, Fengyan Fang, Ziang Gao, Wenli Ding, Yixiang Wang, Jing Wang, Junqiao Wang, Ao Huang, Aohua Cheng, Yanhui Wei, Shiyun Ai. (2021) ATP-triggered drug release system based on ZIF-90 loaded porous poly(lactic-co-glycolic acid) microspheres. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 615 (126255). [PMID:]
7. Xiaobang Liu, Ting Yue, Kai Qi, Bao Yu Xia, Zhenyu Chen, Yubing Qiu, Xingpeng Guo. (2020) Probe into metal-organic framework membranes fabricated via versatile polydopamine-assisted approach onto metal surfaces as anticorrosion coatings. CORROSION SCIENCE, 177 (108949). [PMID:]
8. Xiaofeng Shen, Pengfei Yu, Hua Chen, Jiangping Wang, Binjie Lu, Xuefeng Cai, Chun Gu, Guoqiang Liang, Donglin Hao, Qihan Ma, Yuwei Li. (2020) Icariin controlled release on a silk fibroin/mesoporous bioactive glass nanoparticles scaffold for promoting stem cell osteogenic differentiation. RSC Advances, 10 (20): (12105-12112). [PMID:35496600]
9. Dan Zhang, Yu Fan, Gaojie Li, Wei Du, Runlong Li, Yiming Liu, Zhixuan Cheng, Jiaqiang Xu. (2020) Biomimetic synthesis of zeolitic imidazolate frameworks and their application in high performance acetone gas sensors. SENSORS AND ACTUATORS B-CHEMICAL, 302 (127187). [PMID:]
10. Xiaoxu Zhao, Hao Zhang, Sheng Xu, Yan Wang. (2019) ZIF-8 membrane synthesized via covalent-assisted seeding on polyimide substrate for pervaporation dehydration. AICHE JOURNAL, 65 (8): (e16620). [PMID:]
11. Haotian Li, Xinran Zhang, Xi Qi, Xu Zhu, Liming Cheng. (2019) Icariin Inhibits Endoplasmic Reticulum Stress-induced Neuronal Apoptosis after Spinal Cord Injury through Modulating the PI3K/AKT Signaling Pathway. International Journal of Biological Sciences, 15 (2): ( 277–286). [PMID:30745820]
12. Yan Dan, He Yu, Ge Yili, Song Gongwu. (2017) Fluorescent Detection of Phosphate in Aqueous Solution Based on Near Infrared Emission Ag2S QDs/Metal − Organic Shell Composite. JOURNAL OF FLUORESCENCE, 27 (1): (227-233). [PMID:27726052]

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ICA - 99%, high purity , CAS No.3374-88-7

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
I648624-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$180.90
I648624-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$540.90
I648624-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$900.90
I648624-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,640.90