Basic Description

Specifications & Purity	10mM in DMSO
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC 50 of 2.1 µM. In Vitro The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 2.1 µM (Antileishmanial)

Associated Targets(Human)

KCNN1 Tchem Small conductance calcium-activated potassium channel protein 1 (1 Activities)

Discover Target: KCNN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN3 Tchem Small conductance calcium-activated potassium channel protein 3 (3 Activities)

Discover Target: KCNN3

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KCNN2 Tchem Small conductance calcium-activated potassium channel protein 2 (2 Activities)

Discover Target: KCNN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Canonical SMILES	C1=CC=NC(=C1)C2=CSC(=N2)NC3=CC=CC=N3
Molecular Weight	254.31

Certificates

Certificate of Analysis(COA)

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Citations of This Product

How to Cite Aladdin Scientific Products?

1. Wenfu Lin, Yan Huang, Zhenru Li, Jiongshen Pan, Tiansheng Huang, Lili Liang, Yanzhen Tan, Jie Li, Li-Peng Sun, Bai-Ou Guan. (2023) ZIF-90-Derived Porous ZnO Coated Optical Microfiber Interferometer Sensor for Enhanced Humidity Sensing and Breath Monitoring. ACS Applied Materials & Interfaces, 15 (26): (32057–32065). [PMID:37352511] [10.1021/acsami.3c06635]
2. Ting Zhang, Keli Dong, Lan Xiao, Guangcheng Li, Zhanwei Zhang. (2022) Effects of Co-Administration of Icariin and Panax notoginseng Saponins on Intestinal Microbiota and Hippocampal Protein Expression in a Mouse Model of Alzheimer’s Disease. Neuropsychiatric Disease and Treatment, [PMID:33061388] [10.2147/NDT.S253972]
3. Zhou Mengyang, Guo Min, Shi Xincui, Ma Jie, Wang Shutao, Wu Shuo, Yan Weiqun, Wu Feng, Zhang Peibiao. (2022) Synergistically Promoting Bone Regeneration by Icariin-Incorporated Porous Microcarriers and Decellularized Extracellular Matrix Derived From Bone Marrow Mesenchymal Stem Cells. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35464719] [10.3389/fbioe.2022.824025]
4. Kun Li, Yingnan Zhang, Junwei Xu, Jingxi Wang, Xuenan Gu, Ping Li, Yubo Fan. (2021) Three-dimensional magnetic fibrous scaffold with icariin expanded by supercritical CO2 for bone tissue engineering under static magnetic field. COMPOSITES PART B-ENGINEERING, 226 (109304). [PMID:] [10.1016/j.compositesb.2021.109304]
5. He Qi, Zheng Li, Haijiao Zheng, Qiong Jia. (2021) Carnosine functionalized magnetic metal–organic framework nanocomposites for synergistic enrichment of phosphopeptides. ANALYTICA CHIMICA ACTA, 1157 (338383). [PMID:33832591] [10.1016/j.aca.2021.338383]
6. Chenxi Yu, Wenyu Zhu, Zhaozhan He, Jin Xu, Fengyan Fang, Ziang Gao, Wenli Ding, Yixiang Wang, Jing Wang, Junqiao Wang, Ao Huang, Aohua Cheng, Yanhui Wei, Shiyun Ai. (2021) ATP-triggered drug release system based on ZIF-90 loaded porous poly(lactic-co-glycolic acid) microspheres. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 615 (126255). [PMID:] [10.1016/j.colsurfa.2021.126255]
7. Xiaobang Liu, Ting Yue, Kai Qi, Bao Yu Xia, Zhenyu Chen, Yubing Qiu, Xingpeng Guo. (2020) Probe into metal-organic framework membranes fabricated via versatile polydopamine-assisted approach onto metal surfaces as anticorrosion coatings. CORROSION SCIENCE, 177 (108949). [PMID:] [10.1016/j.corsci.2020.108949]
8. Xiaofeng Shen, Pengfei Yu, Hua Chen, Jiangping Wang, Binjie Lu, Xuefeng Cai, Chun Gu, Guoqiang Liang, Donglin Hao, Qihan Ma, Yuwei Li. (2020) Icariin controlled release on a silk fibroin/mesoporous bioactive glass nanoparticles scaffold for promoting stem cell osteogenic differentiation. RSC Advances, 10 (20): (12105-12112). [PMID:35496600] [10.1039/D0RA00637H]
9. Dan Zhang, Yu Fan, Gaojie Li, Wei Du, Runlong Li, Yiming Liu, Zhixuan Cheng, Jiaqiang Xu. (2020) Biomimetic synthesis of zeolitic imidazolate frameworks and their application in high performance acetone gas sensors. SENSORS AND ACTUATORS B-CHEMICAL, 302 (127187). [PMID:] [10.1016/j.snb.2019.127187]
10. Xiaoxu Zhao, Hao Zhang, Sheng Xu, Yan Wang. (2019) ZIF-8 membrane synthesized via covalent-assisted seeding on polyimide substrate for pervaporation dehydration. AICHE JOURNAL, 65 (8): (e16620). [PMID:] [10.1002/aic.16620]
11. Haotian Li, Xinran Zhang, Xi Qi, Xu Zhu, Liming Cheng. (2019) Icariin Inhibits Endoplasmic Reticulum Stress-induced Neuronal Apoptosis after Spinal Cord Injury through Modulating the PI3K/AKT Signaling Pathway. International Journal of Biological Sciences, 15 (2): ( 277–286). [PMID:30745820] [10.7150/ijbs.30348]
12. Yan Dan, He Yu, Ge Yili, Song Gongwu. (2017) Fluorescent Detection of Phosphate in Aqueous Solution Based on Near Infrared Emission Ag2S QDs/Metal − Organic Shell Composite. JOURNAL OF FLUORESCENCE, 27 (1): (227-233). [PMID:27726052] [10.1007/s10895-016-1949-2]

References

1. Wenfu Lin, Yan Huang, Zhenru Li, Jiongshen Pan, Tiansheng Huang, Lili Liang, Yanzhen Tan, Jie Li, Li-Peng Sun, Bai-Ou Guan. (2023) ZIF-90-Derived Porous ZnO Coated Optical Microfiber Interferometer Sensor for Enhanced Humidity Sensing and Breath Monitoring. ACS Applied Materials & Interfaces, 15 (26): (32057–32065). [PMID:37352511] [10.1021/acsami.3c06635]
2. Ting Zhang, Keli Dong, Lan Xiao, Guangcheng Li, Zhanwei Zhang. (2022) Effects of Co-Administration of Icariin and Panax notoginseng Saponins on Intestinal Microbiota and Hippocampal Protein Expression in a Mouse Model of Alzheimer’s Disease. Neuropsychiatric Disease and Treatment, [PMID:33061388] [10.2147/NDT.S253972]
3. Zhou Mengyang, Guo Min, Shi Xincui, Ma Jie, Wang Shutao, Wu Shuo, Yan Weiqun, Wu Feng, Zhang Peibiao. (2022) Synergistically Promoting Bone Regeneration by Icariin-Incorporated Porous Microcarriers and Decellularized Extracellular Matrix Derived From Bone Marrow Mesenchymal Stem Cells. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35464719] [10.3389/fbioe.2022.824025]
4. Kun Li, Yingnan Zhang, Junwei Xu, Jingxi Wang, Xuenan Gu, Ping Li, Yubo Fan. (2021) Three-dimensional magnetic fibrous scaffold with icariin expanded by supercritical CO2 for bone tissue engineering under static magnetic field. COMPOSITES PART B-ENGINEERING, 226 (109304). [PMID:] [10.1016/j.compositesb.2021.109304]
5. He Qi, Zheng Li, Haijiao Zheng, Qiong Jia. (2021) Carnosine functionalized magnetic metal–organic framework nanocomposites for synergistic enrichment of phosphopeptides. ANALYTICA CHIMICA ACTA, 1157 (338383). [PMID:33832591] [10.1016/j.aca.2021.338383]
6. Chenxi Yu, Wenyu Zhu, Zhaozhan He, Jin Xu, Fengyan Fang, Ziang Gao, Wenli Ding, Yixiang Wang, Jing Wang, Junqiao Wang, Ao Huang, Aohua Cheng, Yanhui Wei, Shiyun Ai. (2021) ATP-triggered drug release system based on ZIF-90 loaded porous poly(lactic-co-glycolic acid) microspheres. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 615 (126255). [PMID:] [10.1016/j.colsurfa.2021.126255]
7. Xiaobang Liu, Ting Yue, Kai Qi, Bao Yu Xia, Zhenyu Chen, Yubing Qiu, Xingpeng Guo. (2020) Probe into metal-organic framework membranes fabricated via versatile polydopamine-assisted approach onto metal surfaces as anticorrosion coatings. CORROSION SCIENCE, 177 (108949). [PMID:] [10.1016/j.corsci.2020.108949]
8. Xiaofeng Shen, Pengfei Yu, Hua Chen, Jiangping Wang, Binjie Lu, Xuefeng Cai, Chun Gu, Guoqiang Liang, Donglin Hao, Qihan Ma, Yuwei Li. (2020) Icariin controlled release on a silk fibroin/mesoporous bioactive glass nanoparticles scaffold for promoting stem cell osteogenic differentiation. RSC Advances, 10 (20): (12105-12112). [PMID:35496600] [10.1039/D0RA00637H]
9. Dan Zhang, Yu Fan, Gaojie Li, Wei Du, Runlong Li, Yiming Liu, Zhixuan Cheng, Jiaqiang Xu. (2020) Biomimetic synthesis of zeolitic imidazolate frameworks and their application in high performance acetone gas sensors. SENSORS AND ACTUATORS B-CHEMICAL, 302 (127187). [PMID:] [10.1016/j.snb.2019.127187]
10. Xiaoxu Zhao, Hao Zhang, Sheng Xu, Yan Wang. (2019) ZIF-8 membrane synthesized via covalent-assisted seeding on polyimide substrate for pervaporation dehydration. AICHE JOURNAL, 65 (8): (e16620). [PMID:] [10.1002/aic.16620]
11. Haotian Li, Xinran Zhang, Xi Qi, Xu Zhu, Liming Cheng. (2019) Icariin Inhibits Endoplasmic Reticulum Stress-induced Neuronal Apoptosis after Spinal Cord Injury through Modulating the PI3K/AKT Signaling Pathway. International Journal of Biological Sciences, 15 (2): ( 277–286). [PMID:30745820] [10.7150/ijbs.30348]
12. Yan Dan, He Yu, Ge Yili, Song Gongwu. (2017) Fluorescent Detection of Phosphate in Aqueous Solution Based on Near Infrared Emission Ag2S QDs/Metal − Organic Shell Composite. JOURNAL OF FLUORESCENCE, 27 (1): (227-233). [PMID:27726052] [10.1007/s10895-016-1949-2]

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ICA - 10mM in DMSO, high purity , CAS No.3374-88-7(DMSO)