Icilin,AG-3-5 - >96%, high purity , CAS No.36945-98-9, Activator of TRPA1;Activator of TRPM8

Item Number

I303569

• Synonyms: AG 3-5 | AG 3-5; AG3-5; AG-3-5 | EU-0100426 | GTPL2429 | MLS002153471 | 1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-1,2,3,6-tetrahydropyrimidin-2-one | 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one. | Lopac0_000426 | NCGC00025205-01 | NCGC000
• Specifications & Purity: Moligand™, ≥96%
• Biochemical and Physiological Mechanisms: TRPM8 agonist (EC 50 values are 0.4 and 7 μM in the presence and absence of Ca 2+ respectively). Super-cooling agent. Weakly activates TRPA1. Inhibits TRPV3 (IC 50 values are 0.5 and 7 μM in the presence and absence of Ca2+ respectively).
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ACTIVATOR
• Mechanism of action: Activator of TRPA1;Activator of TRPM8
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

General description：

Icilin is a synthetic cooling agent and modulates human transient receptor potential cation channel (TRPA1). Icilin inhibits transient receptor potential cation channel subfamily M member 8 (TRPM8) and modulates calcium release. Icilin also suppresses transient receptor potential vanilloid subtype 3 (TRPV3).

application：
Icilin has been used as cooling agent in anterior ventromedial preoptic area (VMPO) neurons.

Biochemical/Physiological Effects：

Icilin is a potent agonist at the CMR1 cold- and menthol-sensitive receptor.