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Iclaprim - ≥95%, high purity , Bacterial dihydrofolate reductase inhibitor, CAS No.192314-93-5, Bacterial dihydrofolate reductase inhibitor

Moligand™

≥95%

CAS#: 192314-93-5
Formula: C₁₉H₂₂N₄O₃
Molecular Weight: 354.40
PubChem CID: 213043

Item Number

I333706

Grouped product items
SKU	Size	Availability	Price
I333706-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$139.90
I333706-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$417.90
I333706-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$625.90
I333706-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$937.90

a compound with antibacterial properties

View related series

dihydrofolate reductase Inhibitor

Basic Description

Synonyms	5-((2-Cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl)pyrimidine-2,4-diamine \| FT-0670272 \| GTPL10820 \| DTXSID70870191 \| ICLAPRIM [MI] \| MFCD09837803 \| BCP04499 \| J-515882 \| A835145 \| FT-0670271 \| Iclaprim \| Ro-482622 \| RO-48-2622 \| AR-100AR-100 \| 5-{[(2
Specifications & Purity	≥95%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Bacterial dihydrofolate reductase inhibitor
Product Description	Iclaprim (AR-100) is a novel specific bacterial Dihydrofolate inhibitor. It can inhibit the growth of S. aureus (MIC90: 0.06 μg/mL).

Product Properties

ALogP	2.5

Associated Targets(Human)

DHFR Tclin Dihydrofolate reductase (3 Activities)

Discover Target: DHFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DHFR Tclin Dihydrofolate reductase (3072 Activities)

Discover Target: DHFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK293 (82097 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Streptococcus pneumoniae (31063 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pseudomonas aeruginosa (123386 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Klebsiella pneumoniae (43867 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus aureus (210822 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Acinetobacter baumannii (41033 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Moraxella catarrhalis (3334 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Haemophilus influenzae (8812 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Streptococcus agalactiae (1777 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Enterococcus faecium (13803 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Enterococcus faecalis (29875 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cryptococcus neoformans (21258 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Candida albicans (78123 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Enterococcus sp. (726 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Streptococcus sp. 'group A' (3417 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Streptococcus sp. 'group B' (533 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Serum (58 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine
INCHI	InChI=1S/C19H22N4O3/c1-24-15-8-11(7-12-9-22-19(21)23-18(12)20)13-5-6-14(10-3-4-10)26-16(13)17(15)25-2/h5-6,8-10,14H,3-4,7H2,1-2H3,(H4,20,21,22,23)
InChi Key	HWJPWWYTGBZDEG-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C2=C(C=CC(O2)C3CC3)C(=C1)CC4=CN=C(N=C4N)N)OC
Isomeric SMILES	COC1=C(C2=C(C=CC(O2)C3CC3)C(=C1)CC4=CN=C(N=C4N)N)OC
PubChem CID	213043
Molecular Weight	354.40

Database links

PubChem CID	213043
CAS Registry No.	192314-93-5
ChEMBL Ligand	CHEMBL134561
Antibiotic DB	1966
DrugCentral Ligand	4573

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

8 results found

Lot Number	Certificate Type	Date	Item
G2419095	Certificate of Analysis	Apr 18, 2024	I333706
G2419096	Certificate of Analysis	Apr 18, 2024	I333706
G2419097	Certificate of Analysis	Apr 18, 2024	I333706
G2419098	Certificate of Analysis	Apr 18, 2024	I333706
G2419099	Certificate of Analysis	Apr 18, 2024	I333706
G2419100	Certificate of Analysis	Apr 18, 2024	I333706
G2419101	Certificate of Analysis	Apr 18, 2024	I333706
G2419111	Certificate of Analysis	Apr 18, 2024	I333706

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Warning
Hazard Statements	H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice.

References

1. Sader HS, Fritsche TR, Jones RN. (2009) Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates.. Antimicrob Agents Chemother, 53 (5): (2171-5). [PMID:19289528]
2. Huang DB, Strader CD, MacDonald JS, VanArendonk M, Peck R, Holland T. (2018) An Updated Review of Iclaprim: A Potent and Rapidly Bactericidal Antibiotic for the Treatment of Skin and Skin Structure Infections and Nosocomial Pneumonia Caused by Gram-Positive Including Multidrug-Resistant Bacteria.. Open Forum Infect Dis, 5 (2): (ofy003). [PMID:29423421]
3. Bryant AE, Gomi S, Katahira E, Huang DB, Stevens DL. (2019) The effects of iclaprim on exotoxin production in methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.. J Med Microbiol, 68 (3): (456-466). [PMID:30676310]

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