Selective, Ca 2+ permeable GluR2-lacking AMPA receptor blocker (IC 50 values are 2.6 and 1102 μM for GluR2-lacking and GluR2-containing receptors, respectively). Blocks NMDA receptor-mediated currents. Shows anticonvulsant effects in vivo.
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Associated Targets(Human)
ALOX15BTchemArachidonate 15-lipoxygenase, type II (7244 Activities)
1.Li X et al.. (2021) A circuit of mossy cells controls the efficacy of memory retrieval by Gria2I inhibition of Gria2.. Cell Rep, 34 (7):(108741). [PMID:33596426]
2.Glasgow SD et al.. (2018) Activity-Dependent Netrin-1 Secretion Drives Synaptic Insertion of GluA1-Containing AMPA Receptors in the Hippocampus.. Cell Rep, 25 (168-182.e6). [PMID:30282026]
3.Livingstone RW et al.. (2021) Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of Ca2+-Permeable AMPA Receptors.. Front Mol Neurosci, 14 (660208). [PMID:33867938]
Solution Calculators
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