IL-15-IN-1 - 98%, high purity , CAS No.1831830-20-6

Item Number

I412820

Grouped product items
SKU	Size	Availability	Price
I412820-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$399.90
I412820-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$699.90
I412820-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$979.90
I412820-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,359.90

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Basic Description

Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	IL-15-IN-1 is a potent and selective inhibitor of Interleukin 15 (IL-15) that inhibits the proliferation of IL-15-dependent cells with IC50 of 0.8 μM.
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Information IL-15-IN-1 is a potent and selective inhibitor of Interleukin 15 (IL-15) that inhibits the proliferation of IL-15-dependent cells with IC50 of 0.8 μM.

Names and Identifiers

IUPAC Name	ethyl 3-[8-[[4-methyl-5-[(3-methyl-4-oxophthalazin-1-yl)methyl]-1,2,4-triazol-3-yl]sulfanyl]octanoylamino]benzoate
INCHI	InChI=1S/C30H36N6O4S/c1-4-40-29(39)21-13-12-14-22(19-21)31-27(37)17-8-6-5-7-11-18-41-30-33-32-26(35(30)2)20-25-23-15-9-10-16-24(23)28(38)36(3)34-25/h9-10,12-16,19H,4-8,11,17-18,20H2,1-3H3,(H,31,37)
InChi Key	GWNFQAKCJYEJEW-UHFFFAOYSA-N
Canonical SMILES	CCOC(=O)C1=CC(=CC=C1)NC(=O)CCCCCCCSC2=NN=C(N2C)CC3=NN(C(=O)C4=CC=CC=C43)C
Isomeric SMILES	CCOC(=O)C1=CC(=CC=C1)NC(=O)CCCCCCCSC2=NN=C(N2C)CC3=NN(C(=O)C4=CC=CC=C43)C
PubChem CID	129320517
Molecular Weight	576.71

Certificates

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7 results found

Lot Number	Certificate Type	Date	Item
B2402201	Certificate of Analysis	Jan 02, 2024	I412820
B2402202	Certificate of Analysis	Jan 02, 2024	I412820
B2402203	Certificate of Analysis	Jan 02, 2024	I412820
B2402204	Certificate of Analysis	Jan 02, 2024	I412820
B2402205	Certificate of Analysis	Jan 02, 2024	I412820
B2402206	Certificate of Analysis	Jan 02, 2024	I412820
B2402207	Certificate of Analysis	Jan 02, 2024	I412820

Solubility

DMSO: 122 mg/mL (211.55 mM), Need ultrasonic

Sensitivity

Light sensitive；Heat sensitive

References

1. Mortier E, Quéméner A, Vusio P, Lorenzen I, Boublik Y, Grötzinger J, Plet A, Jacques Y. (2006) Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins.. J Biol Chem, 281 (3): (1612-9). [PMID:16284400] [10.1021/op500134e]
2. Quéméner A, Maillasson M, Arzel L, Sicard B, Vomiandry R, Mortier E, Dubreuil D, Jacques Y, Lebreton J, Mathé-Allainmat M. (2017) Discovery of a Small-Molecule Inhibitor of Interleukin 15: Pharmacophore-Based Virtual Screening and Hit Optimization.. J Med Chem, 60 (14): (6249-6272). [PMID:28657314] [10.1021/op500134e]

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Basic Description