IL-17A, CAS No.rp174282, Agonist of Interleukin-17 receptor

Features and benefits
    Item Number
    rp174282
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    rp174282-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $1,334.90
    rp174282-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,334.90
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    Interleukin-17 receptor Agonist

    Basic Description

    Product NameIL-17A, CAS No.rp174282
    SynonymsCTLA-8;interleukin-17 alpha
    GradeMoligand™
    Specifications & PurityMoligand™
    Action TypeAGONIST
    Mechanism of actionAgonist of Interleukin-17 receptor

    Associated Targets(Human)

    IL17RA Tclin Interleukin-17 receptor A (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    IL17RC Tclin Interleukin-17 receptor C (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    CASrp174282

    Certificates

    Certificate of Analysis(COA)

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    Genetic information

    Alternate NamesCTLA-8;interleukin-17 alpha
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    References

    1. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q et al..  (2005)  A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17..  Nat Immunol,  (11): (1133-41).  [PMID:16200068] [10.1021/op500134e]
    2. Harper EG, Guo C, Rizzo H, Lillis JV, Kurtz SE, Skorcheva I, Purdy D, Fitch E, Iordanov M, Blauvelt A.  (2009)  Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis..  J Invest Dermatol,  129  (9): (2175-83).  [PMID:19295614] [10.1021/op500134e]
    3. Onishi RM, Gaffen SL.  (2010)  Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease..  Immunology,  129  (3): (311-21).  [PMID:20409152] [10.1021/op500134e]
    4. Lin AM, Rubin CJ, Khandpur R, Wang JY, Riblett M, Yalavarthi S, Villanueva EC, Shah P, Kaplan MJ, Bruce AT.  (2011)  Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis..  J Immunol,  187  (1): (490-500).  [PMID:21606249] [10.1021/op500134e]
    5. Cai Y, Shen X, Ding C, Qi C, Li K, Li X, Jala VR, Zhang HG, Wang T, Zheng J et al..  (2011)  Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation..  Immunity,  35  (4): (596-610).  [PMID:21982596] [10.1021/op500134e]
    6. Martin DA, Towne JE, Kricorian G, Klekotka P, Gudjonsson JE, Krueger JG, Russell CB.  (2013)  The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings..  J Invest Dermatol,  133  (1): (17-26).  [PMID:22673731] [10.1021/op500134e]
    7. Zhu S, Qian Y.  (2012)  IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential..  Clin Sci,  122  (11): (487-511).  [PMID:22324470] [10.1021/op500134e]
    8. Cai Y, Fleming C, Yan J.  (2013)  Dermal γδ T cells--a new player in the pathogenesis of psoriasis..  Int Immunopharmacol,  16  (3): (388-91).  [PMID:23499509] [10.1021/op500134e]
    9. Ganesan R, Rasool M.  (2017)  Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61, IL-23 and GM-CSF expression and RANKL mediated osteoclastogenesis by fibroblast-like synoviocytes in rheumatoid arthritis..  Mol Immunol,  91  (13): (134-144).  [PMID:28898718] [10.1021/op500134e]
    10. Ishibashi N, Watanabe T, Kanehira M, Watanabe Y, Hoshikawa Y, Notsuda H, Noda M, Sakurada A, Ohkouchi S, Kondo T et al..  (2018)  Bone marrow mesenchymal stromal cells protect allograft lung transplants from acute rejection via the PD-L1/IL-17A axis..  Surg Today,  48  (7): (726-734).  [PMID:29546496] [10.1021/op500134e]

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