IL-2, CAS No.rp174292, Agonist of Interleukin-2 receptor

Features and benefits
    Item Number
    rp174292
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    rp174292-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $1,334.90
    rp174292-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,334.90
    View related series
    Interleukin-2 receptor Agonist

    Basic Description

    Product NameIL-2, CAS No.rp174292
    Synonymsaldesleukin;interleukin-2;Proleukin
    GradeMoligand™
    Specifications & PurityMoligand™
    Action TypeAGONIST
    Mechanism of actionAgonist of Interleukin-2 receptor

    Associated Targets(Human)

    IL2RB Tclin Interleukin-2 receptor subunit beta (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    IL2RA Tclin Interleukin-2 receptor subunit alpha (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    IL2RG Tclin Cytokine receptor common subunit gamma (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    CASrp174292

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    Certificate of Analysis(COA)

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    Genetic information

    Alternate Namesaldesleukin;interleukin-2;Proleukin
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    References

    1. Waldmann TA.  (2006)  The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design..  Nat Rev Immunol,  (8): (595-601).  [PMID:16868550] [10.1021/op500134e]
    2. Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY.  (2005)  A function for interleukin 2 in Foxp3-expressing regulatory T cells..  Nat Immunol,  (11): (1142-51).  [PMID:16227984] [10.1021/op500134e]
    3. Klatzmann D, Abbas AK.  (2015)  The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases..  Nat Rev Immunol,  15  (5): (283-94).  [PMID:25882245] [10.1021/op500134e]
    4. Abbas AK, Trotta E, R Simeonov D, Marson A, Bluestone JA.  (2018)  Revisiting IL-2: Biology and therapeutic prospects..  Sci Immunol,  (25): (1755-70).  [PMID:29980618] [10.1021/op500134e]
    5. Trotta E, Bessette PH, Silveria SL, Ely LK, Jude KM, Le DT, Holst CR, Coyle A, Potempa M, Lanier LL et al..  (2018)  A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism..  Nat Med,  24  (7): (1005-1014).  [PMID:29942088] [10.1021/op500134e]

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