Ilaprazole - 98%, high purity , Potassium-transporting ATPase inhibitor, CAS No.172152-36-2, Potassium-transporting ATPase inhibitor

Item Number
I332490
Grouped product items
SKUSizeAvailabilityPrice Qty
I332490-100mg
100mg
In stock
$1,018.90
I332490-250mg
250mg
In stock
$2,292.90
I332490-1g
1g
In stock
$8,253.90
I332490-5g
5g
In stock
$37,142.90

a proton pump inhibitor (PPI)

Basic Description

Synonymss3666 | CS-6444 | ILAPRAZOLE [WHO-DD] | DTXSID10870115 | 2-[(4-methoxy-3-methyl-pyridin-2-yl)methylsulfinyl]-6-pyrrol-1-yl-1h-benzoimidazole | GTPL10512 | 1H-Benzimidazole,2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-5-(1H-pyrrol-1-yl)- (9CI) | Il
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsIlaprazole is a proton pump inhibitor (H+/K+ ATPase inhibitor) that suppresses acids secretion. Ilaprazole is a potent and selective inhibitor of T-cell-originated protein kinase (TOPK) that suppresses cancer growth.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionPotassium-transporting ATPase inhibitor

Product Properties

ALogP2.3

Associated Targets(Human)

ATP4A Tclin Potassium-transporting ATPase alpha chain 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-6-pyrrol-1-yl-1H-benzimidazole
INCHI InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22)
InChi Key HRRXCXABAPSOCP-UHFFFAOYSA-N
Canonical SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=C(N2)C=C(C=C3)N4C=CC=C4)OC
Isomeric SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=C(N2)C=C(C=C3)N4C=CC=C4)OC
PubChem CID 214351
Molecular Weight 366.44

Certificates

Certificate of Analysis(COA)

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4 results found

Lot NumberCertificate TypeDateItem
K2221015Certificate of AnalysisSep 15, 2022 I332490
K2221047Certificate of AnalysisSep 15, 2022 I332490
K2221053Certificate of AnalysisSep 15, 2022 I332490
K2221054Certificate of AnalysisSep 15, 2022 I332490

Chemical and Physical Properties

Refractive Indexn20D1.71 (Predicted)
Boil Point(°C)~651.0° C at 760 mmHg (Predicted)
Melt Point(°C)271.46° C (Predicted)

Related Documents

References

1. Kwon D, Chae JB, Park CW, Kim YS, Lee SM, Kim EJ, Huh IH, Kim DY, Cho KD.  (2001)  Effects of IY-81149, a newly developed proton pump inhibitor, on gastric acid secretion in vitro and in vivo..  Arzneimittelforschung,  51  (3): (204-13).  [PMID:11304936] [10.1021/op500134e]
2. Zhou G, Shi S, Zhang W, Tan Z, Chen Y, Guo D, Zhou H, Hu H, Tan J.  (2010)  Identification of ilaprazole metabolites in human urine by HPLC-ESI-MS/MS and HPLC-NMR experiments..  Biomed Chromatogr,  24  (10): (1130-5).  [PMID:20352613] [10.1021/op500134e]
3. Wang L, Zhou L, Hu H, Lin S, Xia J.  (2012)  Ilaprazole for the treatment of duodenal ulcer: a randomized, double-blind and controlled phase III trial..  Curr Med Res Opin,  28  (1): (101-9).  [PMID:22070512] [10.1021/op500134e]
4. Ji XQ, Du JF, Chen G, Chen G, Yu B.  (2014)  Efficacy of ilaprazole in the treatment of duodenal ulcers: a meta-analysis..  World J Gastroenterol,  20  (17): (5119-23).  [PMID:24803828] [10.1021/op500134e]
5. Pu J, Wang F, Tang W, Zhu M.  (2018)  Biotransformation of Ilaprazole in Human Liver Microsomes and Human: Role of CYP3A4 in Ilaprazole Clearance and Drug-Drug Interaction..  Drug Metab Dispos,  46  (10): (1453-1461).  [PMID:30002078] [10.1021/op500134e]

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