| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab175560-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $89.90 | |
| Ab175560-1mg | 1mg | In stock | $429.90 | |
| Ab175560-5mg | 5mg | In stock | $1,099.90 | |
| Ab175560-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,749.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Imaprelimab (anti-CD146) - Primary antibody, specific to MCAM, >95%, high purity, Human IgG1 |
|---|---|
| Synonyms | A32 antigen antibody | CD 146 antibody | CD146 antibody | CD146 antigen antibody | Cell surface glycoprotein MUC18 antibody | Cell surface glycoprotein P1H12 antibody | Gicerin antibody | Mcam antibody | Melanoma adhesion molecule antibody | Melanoma asso |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
| Host species | Human |
| Specificity | MCAM |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | ANTIBODY |
| Mechanism of action | Antibody of melanoma cell adhesion molecule |
| Product Description | Imaprelimab (anti-CD146) is a humanized IgG1κ anti-melanoma cell adhesion molecule (MCAM) monoclonal antibody. Imaprelimab (anti-CD146) is an antineoplastic agent. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 144.74 kDa |
| Purification Method | Protein A purified |
| Purity | >95% |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 2014343-04-3 |
Imaprelimab (anti-CD146) (Ab175560) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling CD146 (red) with Imaprelimab (anti-CD146) (Ab175560). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Imaprelimab (anti-CD146) (Ab175560) - Flow Cytometry
Flow Cytometry analysis of A375 cells labelling CD146 (red) with Imaprelimab (anti-CD146) (Ab175560). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Imaprelimab (anti-CD146) (Ab175560) - SEC
The purity of Imaprelimab (anti-CD146) (Ab175560) is more than 95% verified by HPLC.
Imaprelimab (anti-CD146) (Ab175560) - ELISA
Immobilized Recombinant Human MCAM/CD146 Protein (rp183759) at 1.0 μg/mL can bind Imaprelimab (anti-CD146) (Ab175560) with the EC50 of 30.9 ng/mL.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IMGT/mAb-DB | 808 |
|---|
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ23F1202180 | Certificate of Analysis | Dec 22, 2023 | Ab175560 |
| ZJ23F1202179 | Certificate of Analysis | Dec 22, 2023 | Ab175560 |
| 1. Wu C, Goodall JC, Busch R, Gaston JS. (2015) Relationship of CD146 expression to secretion of interleukin (IL)-17, IL-22 and interferon-γ by CD4(+) T cells in patients with inflammatory arthritis.. Clin Exp Immunol, 179 (3): (378-91). [PMID:25113810] [10.1021/op500134e] |
| 2. Dagur PK, McCoy Jr JP. (2015) Endothelial-binding, proinflammatory T cells identified by MCAM (CD146) expression: Characterization and role in human autoimmune diseases.. Autoimmun Rev, 14 (5): (415-22). [PMID:25595133] [10.1021/op500134e] |
