IC50 Value: 100 nM (PDGFR) ; 100 nM (c-Kit)
Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. Imatinib is used to treat chronic myelogenous leukemia (CML), gastrointestinal stromal tumors
Storage Temp
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of ABL proto-oncogene 1; non-receptor tyrosine kinase;Inhibitor of discoidin domain receptor tyrosine kinase 1;Inhibitor of discoidin domain receptor tyrosine kinase 2
Note
250mg卖完停产，不再备货
Product Description
Imatinib (STI571) is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. An inhibitor of multiple tyrosine kinases
Associated Targets
CTNNBIP1Tbio Beta-catenin-interacting protein 1 0 Activities
1.Takeuchi K, Koike K, Kamijo T, Ishida S, Nakazawa Y, Kurokawa Y, Sakashita K, Kinoshita T, Matsuzawa S, Shiohara M et al.. (2003) STI571 inhibits growth and adhesion of human mast cells in culture.. J Leukoc Biol, 74 (6):(1026-34). [PMID:12960256]
2.Rhee CK, Kim JW, Park CK, Kim JS, Kang JY, Kim SJ, Kim SC, Kwon SS, Kim YK, Park SH et al.. (2011) Effect of imatinib on airway smooth muscle thickening in a murine model of chronic asthma.. Int Arch Allergy Immunol, 155 (3):(243-51). [PMID:21293142]
3.Ustun C, DeRemer DL, Akin C. (2011) Tyrosine kinase inhibitors in the treatment of systemic mastocytosis.. Leuk Res, 35 (9):(1143-52). [PMID:21641642]
4.Coleman CM, Sisk JM, Mingo RM, Nelson EA, White JM, Frieman MB. (2016) Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion.. J Virol, 90 (19):(8924-33). [PMID:27466418]
5.Sisk JM, Frieman MB, Machamer CE. (2018) Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors.. J Gen Virol, 99 (5):(619-630). [PMID:29557770]
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