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IMD 0354 - ≥99%, high purity , CAS No.978-62-1
Discover IMD 0354 by Aladdin Scientific in ≥99% for only $84.90. Available - in Ligands at Aladdin Scientific. Potent, selective cell-permeable IKKβ inhibitor Tags: .
Basic Description Synonyms IMD-0354|978-62-1|IMD 0354|N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide|IKK-2 Inhibitor V|IMD0354|N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide|TCMDC-125465|CHEMBL536151|Benzamide, N-(3,5-bis(trifluoromethyl)phenyl)-5-ch Specifications & Purity ≥99% Storage Temp Store at -20°C Shipped In Dry ice Product Description application：
IMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2. It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts.
Names and Identifiers IUPAC Name N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide INCHI InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25) InChi Key CHILCFMQWMQVAL-UHFFFAOYSA-N Canonical SMILES C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O Isomeric SMILES C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O WGK Germany 3 PubChem CID 5081913 Molecular Weight 383.67
Chemical and Physical Properties Solubility DMSO 10 mg/mL Water <1 mg/mL Ethanol 77 mg/mL
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3
References 1. Miyagawa Y et al.. (2020) Evaluation of cancer-derived myocardial impairments using a mouse model.. Oncotarget, 11 (41): (3712-3722). [PMID:33110478 ] 2. Sheng J et al.. (2021) Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy.. Hepatology, 74 (4): (1971-1993). [PMID:33931882 ]
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