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Imidafenacin - 98%, high purity , Muscarinic acetylcholine receptor M3 antagonist, CAS No.170105-16-5, Muscarinic acetylcholine receptor M3 antagonist
mAChR Selective Inhibitors | Agonists | Antagonists | Modulators
Basic Description Synonyms Imidafenacin|170105-16-5|Uritos|Staybla|KRP-197|4-(2-Methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide|Imidafenacin [INN]|4-(2-Methyl-1-imidazolyl)-2,2-diphenylbutanamide|ONO-8025|XJR8Y07LJO|4-(2-methylimidazol-1-yl)-2,2-diphenylbutanamide|KRP-197;ONO-8025| Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a p Storage Temp Protected from light,Store at -20°C Shipped In Ice chest + Ice pads Action Type ANTAGONIST Mechanism of action Muscarinic acetylcholine receptor M3 antagonist Product Description Information
Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). IC50 value: 0.3 nM(M3).
Targets
M3 receptor (Cell-free assay); M3 receptor (Cell-free assay); M2 receptor (Cell-free assay) 0.3 nM; 0.317 nM(Kd); 4.13 nM
Product Properties ALogP 2.55 HBD Count 1 Rotatable Bond 6
Names and Identifiers Pubchem Sid 488195772 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488195772 IUPAC Name 4-(2-methylimidazol-1-yl)-2,2-diphenylbutanamide INCHI InChI=1S/C20H21N3O/c1-16-22-13-15-23(16)14-12-20(19(21)24,17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11,13,15H,12,14H2,1H3,(H2,21,24) InChi Key SQKXYSGRELMAAU-UHFFFAOYSA-N Canonical SMILES CC1=NC=CN1CCC(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N Isomeric SMILES CC1=NC=CN1CCC(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N PubChem CID 6433090 Molecular Weight 319.4
Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 63 mg/mL (197.24 mM); Sensitivity Light & Heat sensitive DMSO(mg / mL) Max Solubility 63 DMSO(mM) Max Solubility 197.244685852459 Water(mg / mL) Max Solubility -1 Water(mM) Max Solubility -3.13086802940411
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P270: Do not eat, drink or smoke when using this product.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
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