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Imidafenacin - 98%, high purity , Muscarinic acetylcholine receptor M3 antagonist, CAS No.170105-16-5, Muscarinic acetylcholine receptor M3 antagonist

  • ≥98%
Item Number
I413279
Grouped product items
SKUSizeAvailabilityPrice Qty
I413279-25mg
25mg
In stock
$92.90
I413279-100mg
100mg
In stock
$177.90
I413279-250mg
250mg
In stock
$400.90
I413279-1g
1g
In stock
$1,441.90
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mAChR Selective Inhibitors | Agonists | Antagonists | Modulators

Basic Description

SynonymsIMIDAFENACIN [MI] | MFCD09833703 | A, | Imidafenacin (JAN/INN) | HY-B0662 | Caswell No. 861AA | ONO-8025 | AKOS030526649 | DB09262 | FT-0670290 | Imidafenacin | AS-47648 | D06273 | NCGC00183110-02 | Uritos (TN) | HMS3886C04 | Staybla | XJR8Y07LJO | 4-(2-m
Specifications & Purity≥98%
Biochemical and Physiological MechanismsImidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a p
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
Action TypeANTAGONIST
Mechanism of actionMuscarinic acetylcholine receptor M3 antagonist
Product Description

Information

Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). IC50 value: 0.3 nM(M3).


Targets

M3 receptor (Cell-free assay); M3 receptor (Cell-free assay); M2 receptor (Cell-free assay) 0.3 nM; 0.317 nM(Kd); 4.13 nM

Product Properties

ALogP2.55
HBD Count1
Rotatable Bond6

Associated Targets(Human)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptors; M2 & M3 (708 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M1 and M3 (256 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488195772
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488195772
IUPAC Name 4-(2-methylimidazol-1-yl)-2,2-diphenylbutanamide
INCHI InChI=1S/C20H21N3O/c1-16-22-13-15-23(16)14-12-20(19(21)24,17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11,13,15H,12,14H2,1H3,(H2,21,24)
InChi Key SQKXYSGRELMAAU-UHFFFAOYSA-N
Canonical SMILES CC1=NC=CN1CCC(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N
Isomeric SMILES CC1=NC=CN1CCC(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N
PubChem CID 6433090
Molecular Weight 319.4

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
E2322264Certificate of AnalysisApr 10, 2023 I413279
E2322268Certificate of AnalysisApr 10, 2023 I413279
E2322270Certificate of AnalysisApr 10, 2023 I413279
E2322275Certificate of AnalysisApr 10, 2023 I413279
E2322276Certificate of AnalysisApr 10, 2023 I413279
E2322280Certificate of AnalysisApr 10, 2023 I413279
E2322298Certificate of AnalysisApr 10, 2023 I413279
E2322311Certificate of AnalysisApr 10, 2023 I413279

Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 63 mg/mL (197.24 mM);    
SensitivityLight & Heat sensitive
DMSO(mg / mL) Max Solubility63
DMSO(mM) Max Solubility197.244685852459
Water(mg / mL) Max Solubility-1
Water(mM) Max Solubility-3.13086802940411

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. Imidafenacin - 10mM in DMSO, used for , CAS No. 170105-16-5, by Aladdin Scientific
    Imidafenacin
    • 10mM in DMSO

    Starting at $195.90

Solution Calculators

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