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Imidazole ketone erastin (PUN30119) - 98%, high purity , CAS No.1801530-11-9

≥98%

CAS#: 1801530-11-9
Formula: C₃₅H₃₅ClN₆O₅
Molecular Weight: 655.14
PubChem CID: 91824786

Item Number

I414237

Grouped product items
SKU	Size	Availability	Price
I414237-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$669.90
I414237-10mg	10mg	In stock	$1,003.90
I414237-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,943.90
I414237-50mg	50mg	In stock	$3,052.90
I414237-100mg	100mg	In stock	$4,999.90

Ferroptosis Modulators

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Imidazole ketone erastin (PUN30119, IKE) is a potent, selective, and metabolically stable system xc– inhibitor and inducer of ferroptosis.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Information Imidazole ketone erastin (PUN30119) Imidazole ketone erastin (PUN30119, IKE) is a potent, selective, and metabolically stable system xc– inhibitor and inducer of ferroptosis . Targets Ferroptosis ; system xc– In vitro Imidazole ketone erastin (IKE) is an erastin analog with nanomolar potency, high metabolic stability, and intermediate water solubility. Its treatment potently reduces DLBCL cell number. Cell Research(from reference) Cell lines：DLBCL cell line Concentrations：0-100 μM Incubation Time：24 h

ALogP

4.057

Rotatable Bond

Associated Targets(Human)

SLC7A11 Tchem Cystine/glutamate transporter (1 Activities)

Discover Target: SLC7A11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Liver (3974 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC7A11 Tchem Cystine/glutamate transporter (150 Activities)

Discover Target: SLC7A11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DOHH-2 (352 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SU-DHL-6 (338 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SU-DHL10 (113 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SU-DHL-16 (6 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SU-DHL-2 (105 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SU-DHL-5 (24 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-[[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]methyl]-3-[5-(2-imidazol-1-ylacetyl)-2-propan-2-yloxyphenyl]quinazolin-4-one
INCHI	InChI=1S/C35H35ClN6O5/c1-24(2)47-32-12-7-25(31(43)20-40-14-13-37-23-40)19-30(32)42-33(38-29-6-4-3-5-28(29)35(42)45)21-39-15-17-41(18-16-39)34(44)22-46-27-10-8-26(36)9-11-27/h3-14,19,23-24H,15-18,20-22H2,1-2H3
InChi Key	PSPXJPWGVFNGQI-UHFFFAOYSA-N
Canonical SMILES	CC(C)OC1=C(C=C(C=C1)C(=O)CN2C=CN=C2)N3C(=NC4=CC=CC=C4C3=O)CN5CCN(CC5)C(=O)COC6=CC=C(C=C6)Cl
Isomeric SMILES	CC(C)OC1=C(C=C(C=C1)C(=O)CN2C=CN=C2)N3C(=NC4=CC=CC=C4C3=O)CN5CCN(CC5)C(=O)COC6=CC=C(C=C6)Cl
PubChem CID	91824786
Molecular Weight	655.14

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
F2208411	Certificate of Analysis	May 19, 2022	I414237
F2208412	Certificate of Analysis	May 19, 2022	I414237
F2208413	Certificate of Analysis	May 19, 2022	I414237

Solubility

Solubility (25°C) In vitro DMSO: 100 mg/mL (152.63 mM); Ethanol: 33 mg/mL (50.37 mM); Water: Insoluble;

DMSO(mg / mL) Max Solubility

100

DMSO(mM) Max Solubility

152.639130567512

Water(mg / mL) Max Solubility

＜1

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Imidazole ketone erastin (PUN30119) - 98%, high purity , CAS No.1801530-11-9

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

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