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Imidazole ketone erastin (PUN30119) - 98%, high purity , CAS No.1801530-11-9
Basic Description Synonyms IKE;IKE4(3H)-Quinazolinone,2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]- Specifications & Purity 98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Information
Imidazole ketone erastin (PUN30119) Imidazole ketone erastin (PUN30119, IKE) is a potent, selective, and metabolically stable system xc– inhibitor and inducer of ferroptosis .
Targets
Ferroptosis ; system xc–
In vitro
Imidazole ketone erastin (IKE) is an erastin analog with nanomolar potency, high metabolic stability, and intermediate water solubility. Its treatment potently reduces DLBCL cell number.
Cell Research(from reference)
Cell lines：DLBCL cell line
Concentrations：0-100 μM
Incubation Time：24 h
Product Properties ALogP 4.057 Rotatable Bond 11
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 2-[[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]methyl]-3-[5-(2-imidazol-1-ylacetyl)-2-propan-2-yloxyphenyl]quinazolin-4-one INCHI InChI=1S/C35H35ClN6O5/c1-24(2)47-32-12-7-25(31(43)20-40-14-13-37-23-40)19-30(32)42-33(38-29-6-4-3-5-28(29)35(42)45)21-39-15-17-41(18-16-39)34(44)22-46-27-10-8-26(36)9-11-27/h3-14,19,23-24H,15-18,20-22H2,1-2H3 InChi Key PSPXJPWGVFNGQI-UHFFFAOYSA-N Canonical SMILES CC(C)OC1=C(C=C(C=C1)C(=O)CN2C=CN=C2)N3C(=NC4=CC=CC=C4C3=O)CN5CCN(CC5)C(=O)COC6=CC=C(C=C6)Cl Isomeric SMILES CC(C)OC1=C(C=C(C=C1)C(=O)CN2C=CN=C2)N3C(=NC4=CC=CC=C4C3=O)CN5CCN(CC5)C(=O)COC6=CC=C(C=C6)Cl PubChem CID 91824786 Molecular Weight 655.14
Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 100 mg/mL (152.63 mM); Ethanol: 33 mg/mL (50.37 mM); Water: Insoluble; DMSO(mg / mL) Max Solubility 100 DMSO(mM) Max Solubility 152.639130567512 Water(mg / mL) Max Solubility ＜1
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F2208411