Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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I304258-100mg | 100mg | In stock | $59.90 | |
I304258-250mg | 250mg | In stock | $119.90 | |
I304258-1g | 1g | In stock | $379.90 |
Highly potent, broad spectrum β-lactam antibiotic
Synonyms | imipenem | 64221-86-9 | Imipemide | N-Formimidoylthienamycin | Imipenem anhydrous | Tienamycin | Imipenemum | N-formimidoyl thienamycin | MK 0787 | CHEBI:471744 | Imipenem, N-Formimidoyl thienamycin | (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Highly potent, broad spectrum β-lactam antibiotic (IC 50 = 0.15 μM). Bactericidal effect and capable of interacting with GABA A receptors. Modest penetration of the BBB. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Note | Unstable; make up solutions fresh and use immediately. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description |
Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections.
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Pubchem Sid | 488187374 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488187374 |
IUPAC Name | (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
INCHI | InChI=1S/C12H17N3O4S/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19)/t6-,7-,9-/m1/s1 |
InChi Key | ZSKVGTPCRGIANV-ZXFLCMHBSA-N |
Canonical SMILES | CC(C1C2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O |
Isomeric SMILES | C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O |
PubChem CID | 104838 |
Molecular Weight | 299.34 |
Enter Lot Number to search for COA:
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Lot Number | Certificate Type | Date | Item |
---|---|---|---|
I2402159 | Certificate of Analysis | Aug 21, 2024 | I304258 |
I2402158 | Certificate of Analysis | Aug 21, 2024 | I304258 |
I2402157 | Certificate of Analysis | Aug 21, 2024 | I304258 |
E2429401 | Certificate of Analysis | Apr 24, 2024 | I304258 |
E2429409 | Certificate of Analysis | Apr 24, 2024 | I304258 |
E2429418 | Certificate of Analysis | Apr 24, 2024 | I304258 |
K2324441 | Certificate of Analysis | Oct 21, 2023 | I304258 |
K2324432 | Certificate of Analysis | Oct 21, 2023 | I304258 |
C23111107 | Certificate of Analysis | Feb 25, 2023 | I304258 |
C23111132 | Certificate of Analysis | Feb 25, 2023 | I304258 |
C23111130 | Certificate of Analysis | Feb 25, 2023 | I304258 |
C23111115 | Certificate of Analysis | Feb 25, 2023 | I304258 |
C23111113 | Certificate of Analysis | Feb 25, 2023 | I304258 |
H2325043 | Certificate of Analysis | Jul 22, 2022 | I304258 |
H2325044 | Certificate of Analysis | Jul 22, 2022 | I304258 |
I2207650 | Certificate of Analysis | Jul 22, 2022 | I304258 |
I2207651 | Certificate of Analysis | Jul 22, 2022 | I304258 |
I2207652 | Certificate of Analysis | Jul 22, 2022 | I304258 |
J2313139 | Certificate of Analysis | Jul 22, 2022 | I304258 |
C2226653 | Certificate of Analysis | May 24, 2022 | I304258 |
Pictogram(s) | GHS08, GHS09 |
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Signal | Danger |
Hazard Statements | H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P284:[In case of inadequate ventilation] Wear respiratory protection. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P391:Collect spillage. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately. |
Starting at $34.90
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3. Gui Shumin, Li Xisheng, Feng Mingming, Liu Hui, Huang Liwenhui, Niu Xinqing. (2023) A fresh pH-responsive imipenem-loaded nanocarrier against Acinetobacter baumannii with a synergetic effect. Frontiers in Bioengineering and Biotechnology, 11 [PMID:37113664] |
4. Xuan Ma, Yue Wang, Wenting Wang, Jake Heinlein, Lisa D. Pfefferle, Xuemeng Tian. (2023) Strategic preparation of porous magnetic molecularly imprinted polymers via a simple and green method for high-performance adsorption and removal of meropenem. TALANTA, 258 (124419). [PMID:36893497] |
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6. Mingtian Xu, Zhengjie Xu, Zhijun Jiang, Wenwen Shao, Lihao Zhang, Yufei Chen, Zhixia Dong, Cihui Liu, Weixing Zhang, Xinjian Wan. (2023) Biomimicking integrates peristome surface of Nepenthes alata onto biliary stents tips. CHEMICAL ENGINEERING JOURNAL, 454 (140064). [PMID:] |
7. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] |
8. Shuting Xie, Ri He, Qifan Zhu, Mingliang Jin, Ruizhi Yang, Shitao Shen, Jiayi Cui, Yiying Zou, Minmin Zhang, Lingling Shui. (2022) Label-free optical sensor based on liquid crystal sessile droplet array for penicillin G determination. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 644 (128728). [PMID:] |
1. Cui L, Neoh HM, Shoji M, Hiramatsu K. (2009) Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.. Antimicrob Agents Chemother, 53 (3): (1231-4). [PMID:19124662] |
2. Clark CL, Kosowska-Shick K, Ednie LM, Appelbaum PC. (2007) Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies.. Antimicrob Agents Chemother, 51 (11): (4196-201). [PMID:17876003] |
3. Weilun Pan, Bodeng Wu, Chengtao Nie, Tingting Luo, Zhenli Song, Jie Lv, Yong Tan, Chunchen Liu, Mingzhen Zhong, Tong Liao, Zhenxun Wang, Guanghui Yi, Limin Zhang, Xiaoliu Liu, Bo Li, Jinxiang Chen, Lei Zheng. (2023) NIR-II Responsive Nanohybrids Incorporating Thermosensitive Hydrogel as Sprayable Dressing for Multidrug-Resistant-Bacteria Infected Wound Management. ACS Nano, 17 (12): (11253–11267). [PMID:37314783] |
4. Yexuan Mao, Yichao Fan, Ran Yang, Youyi Wang, Qingyue Li, Meng Dang, Xianqing Huang, Lianjun Song, Pingan Zhang, Miao Song, Liang Liu, Linli Wang, Shun Yu, Qiuyan Zhao, Xiya Zhang. (2023) A highly sensitive electrochemical sensor derived from peptide amphiphilic inspired self-assembled, ordered gold nanoparticles for determination of 22 β-lactams. ELECTROCHIMICA ACTA, 461 (142669). [PMID:] |
5. Gui Shumin, Li Xisheng, Feng Mingming, Liu Hui, Huang Liwenhui, Niu Xinqing. (2023) A fresh pH-responsive imipenem-loaded nanocarrier against Acinetobacter baumannii with a synergetic effect. Frontiers in Bioengineering and Biotechnology, 11 [PMID:37113664] |
6. Xuan Ma, Yue Wang, Wenting Wang, Jake Heinlein, Lisa D. Pfefferle, Xuemeng Tian. (2023) Strategic preparation of porous magnetic molecularly imprinted polymers via a simple and green method for high-performance adsorption and removal of meropenem. TALANTA, 258 (124419). [PMID:36893497] |
7. Zhijun Jiang, Yufei Chen, Mingtian Xu, Wenwen Shao, Lihao Zhang, Cihui Liu. (2023) Bioinspired Superwettable Catheters with Tunable Structural Color for Efficient Drug Release Monitoring. Advanced Materials Interfaces, 10 (8): (2202047). [PMID:] |
8. Mingtian Xu, Zhengjie Xu, Zhijun Jiang, Wenwen Shao, Lihao Zhang, Yufei Chen, Zhixia Dong, Cihui Liu, Weixing Zhang, Xinjian Wan. (2023) Biomimicking integrates peristome surface of Nepenthes alata onto biliary stents tips. CHEMICAL ENGINEERING JOURNAL, 454 (140064). [PMID:] |
9. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] |
10. Shuting Xie, Ri He, Qifan Zhu, Mingliang Jin, Ruizhi Yang, Shitao Shen, Jiayi Cui, Yiying Zou, Minmin Zhang, Lingling Shui. (2022) Label-free optical sensor based on liquid crystal sessile droplet array for penicillin G determination. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 644 (128728). [PMID:] |