Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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I157433-250mg | 250mg | In stock | $20.90 | |
I157433-1g | 1g | In stock | $57.90 | |
I157433-5g | 5g | In stock | $179.90 |
Synonyms | SK-Pramine | Imipramine monohydrochloride | MLS000028430 | N-(gamma-Dimethylaminopropyl)iminodibenzyl hydrochloride | Presamine | 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine | HY-B1490 | N-(gamma-Dimetilaminopropil)-iminodibenzi |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Tricyclic antidepressant with various pharmacological activities. Inhibits reuptake inhibitors (K i values are 19, 98 and >1000 nM for SERT, NET and DAT, respectively). Muscarinic receptor inhibitor (IC 50 = 0.13 μM for M 2 ).Tricyclic antidepressant; inh |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Action Type | INHIBITOR |
Mechanism of action | Norepinephrine transporter inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488180736 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488180736 |
IUPAC Name | 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;hydrochloride |
INCHI | InChI=1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H |
InChi Key | XZZXIYZZBJDEEP-UHFFFAOYSA-N |
Canonical SMILES | CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.Cl |
Isomeric SMILES | CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.Cl |
PubChem CID | 8228 |
Molecular Weight | 316.87 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
E2429424 | Certificate of Analysis | Apr 22, 2024 | I157433 |
E2429425 | Certificate of Analysis | Apr 22, 2024 | I157433 |
J2312620 | Certificate of Analysis | Sep 15, 2023 | I157433 |
J2312621 | Certificate of Analysis | Sep 15, 2023 | I157433 |
J2312622 | Certificate of Analysis | Sep 15, 2023 | I157433 |
L2307131 | Certificate of Analysis | Sep 15, 2023 | I157433 |
D23181021 | Certificate of Analysis | Apr 08, 2023 | I157433 |
D23181031 | Certificate of Analysis | Apr 08, 2023 | I157433 |
D23181034 | Certificate of Analysis | Apr 08, 2023 | I157433 |
D23181041 | Certificate of Analysis | Apr 08, 2023 | I157433 |
D23181045 | Certificate of Analysis | Apr 08, 2023 | I157433 |
L2214037 | Certificate of Analysis | Dec 20, 2022 | I157433 |
Solubility | Soluble in water |
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Sensitivity | light sensitive,Moisture sensitive |
Melt Point(°C) | 173 °C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
Merck Index | 4920 |
Starting at $174.90
1. Yunfeng Zhou, Mingzhu Yan, Ruile Pan, Zhi Wang, Xue Tao, Chenchen Li, Tianji Xia, Xinmin Liu, Qi Chang. (2021) Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation. JOURNAL OF ETHNOPHARMACOLOGY, 265 (113317). [PMID:32861821] [10.1016/j.jep.2020.113317] |
1. Nollet M. (2021) Models of Depression: Unpredictable Chronic Mild Stress in Mice.. Curr Protoc, 1 (8): (e208). [PMID:34406704] |
2. Yue X et al.. (2018) TMC Proteins Modulate Egg Laying and Membrane Excitability through a Background Leak Conductance in C.\xa0elegans.. Neuron, 97 (3): (571-585.e5). [PMID:29395910] |
3. Yunfeng Zhou, Mingzhu Yan, Ruile Pan, Zhi Wang, Xue Tao, Chenchen Li, Tianji Xia, Xinmin Liu, Qi Chang. (2021) Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation. JOURNAL OF ETHNOPHARMACOLOGY, 265 (113317). [PMID:32861821] [10.1016/j.jep.2020.113317] |