Tricyclic antidepressant with various pharmacological activities. Inhibits reuptake inhibitors (K i values are 19, 98 and >1000 nM for SERT, NET and DAT, respectively). Muscarinic receptor inhibitor (IC 50 = 0.13 μM for M 2 ).Tricyclic antidepressant; inh
Storage Temp
Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
Action Type
INHIBITOR
Mechanism of action
Norepinephrine transporter inhibitor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Nollet M. (2021) Models of Depression: Unpredictable Chronic Mild Stress in Mice.. Curr Protoc, 1 (8):(e208). [PMID:34406704]
2.Yue X et al.. (2018) TMC Proteins Modulate Egg Laying and Membrane Excitability through a Background Leak Conductance in C.\xa0elegans.. Neuron, 97 (3):(571-585.e5). [PMID:29395910]
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