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Immethridine dihydrobromide , CAS No.87976-03-2, Agonist of H 3 receptor
a strong and highly selective histamine H3 receptor agonist
Basic Description Synonyms 4-(1H-imidazol-5-ylmethyl)pyridine | Immethridine | GTPL4024 | Q6004930 | UNII-F8ZT2IBM1X | 4-((1H-Imidazol-5-yl)methyl)pyridine | DTXSID401027207 | Pyridine, 4-(1H-imidazol-5-ylmethyl)- | 4-(1H-imidazol-4-yl-methyl)-pyridine | SB17136 | SCHEMBL845141 | C Specifications & Purity Moligand™ Storage Temp Room temperature,Desiccated Shipped In Normal Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of H 3 receptor Product Description Immethridine dihydrobromide is a strong and highly selective histamine H|3|receptor agonist (pEC|50|= 9.74) that displays 300-fold selectivity over the H|4|receptor (pK|i|values are 9.07 and 6.61 respectively). Immethridine dihydrobromide does not bind to H|1|or H|2|receptors at concentrations up to 10 μM.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 4-(1H-imidazol-5-ylmethyl)pyridine INCHI InChI=1S/C9H9N3/c1-3-10-4-2-8(1)5-9-6-11-7-12-9/h1-4,6-7H,5H2,(H,11,12) InChi Key DFVSGZHJSIEEQQ-UHFFFAOYSA-N Canonical SMILES C1=CN=CC=C1CC2=CN=CN2 Isomeric SMILES C1=CN=CC=C1CC2=CN=CN2 PubChem CID 9989505 Molecular Weight 159.19
Chemical and Physical Properties Solubility Soluble to 100 mM in Water
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
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