Immethridine dihydrobromide , CAS No.87976-03-2, Agonist of H 3 receptor

Item Number
I347553
Grouped product items
SKUSizeAvailabilityPrice Qty
I347553-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$137.90
I347553-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$584.90

a strong and highly selective histamine H3 receptor agonist

View related series
H3 receptor Agonist

Basic Description

Synonyms4-(1H-imidazol-5-ylmethyl)pyridine | Immethridine | GTPL4024 | Q6004930 | UNII-F8ZT2IBM1X | 4-((1H-Imidazol-5-yl)methyl)pyridine | DTXSID401027207 | Pyridine, 4-(1H-imidazol-5-ylmethyl)- | 4-(1H-imidazol-4-yl-methyl)-pyridine | SB17136 | SCHEMBL845141 | C
Specifications & PurityMoligand™
Storage TempRoom temperature,Desiccated
Shipped InNormal
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of H 3 receptor
Product Description

Immethridine dihydrobromide is a strong and highly selective histamine H|3|receptor agonist (pEC|50|= 9.74) that displays 300-fold selectivity over the H|4|receptor (pK|i|values are 9.07 and 6.61 respectively). Immethridine dihydrobromide does not bind to H|1|or H|2|receptors at concentrations up to 10 μM.

Associated Targets(Human)

HRH3 Tclin Histamine H3 receptor (9 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH4 Tchem Histamine receptor (H3 and H4) (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hrh4 Histamine H4 receptor (388 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 4-(1H-imidazol-5-ylmethyl)pyridine
INCHI InChI=1S/C9H9N3/c1-3-10-4-2-8(1)5-9-6-11-7-12-9/h1-4,6-7H,5H2,(H,11,12)
InChi Key DFVSGZHJSIEEQQ-UHFFFAOYSA-N
Canonical SMILES C1=CN=CC=C1CC2=CN=CN2
Isomeric SMILES C1=CN=CC=C1CC2=CN=CN2
PubChem CID 9989505
Molecular Weight 159.19

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble to 100 mM in Water

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Related Documents

Solution Calculators