Imperatorin - ≥98% (HPLC), high purity , CAS No.482-44-0

Item Number

I114064

• Synonyms: 8-Isopentenyloxypsoralene | Marmelosin | Pentosalen | 9-(3-Methylbut-2-enyloxy)furo(3,2-g)chromen-7-one | 9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one | HSDB 3497 | NSC 402949 | 8-Isoamylenoxypsoralen | CCRIS 4346 | Ammidin | Marmelide
• Specifications & Purity: ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway.