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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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I413960-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $59.90 | |
I413960-10mg | 10mg | In stock | $102.90 | |
I413960-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $231.90 | |
I413960-50mg | 50mg | In stock | $412.90 | |
I413960-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $685.90 |
Notch Inhibitors
Specifications & Purity | Moligand™, ≥99% |
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Biochemical and Physiological Mechanisms | IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 26 μM. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of notch receptor 1 |
Product Description | Information IMR-1 IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 26 μM. Targets Notch (Cell-free assay) 26 μM Cell Research(from reference) Cell lines:OE33 and 786-0 cells Concentrations:5, 10, 15, 25 μM |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | ethyl 2-[2-methoxy-4-[(E)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetate |
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INCHI | InChI=1S/C15H15NO5S2/c1-3-20-13(17)8-21-10-5-4-9(6-11(10)19-2)7-12-14(18)16-15(22)23-12/h4-7H,3,8H2,1-2H3,(H,16,18,22)/b12-7+ |
InChi Key | QHPJWPQRZMBKTG-KPKJPENVSA-N |
Canonical SMILES | CCOC(=O)COC1=C(C=C(C=C1)C=C2C(=O)NC(=S)S2)OC |
Isomeric SMILES | CCOC(=O)COC1=C(C=C(C=C1)/C=C/2\C(=O)NC(=S)S2)OC |
PubChem CID | 1246059 |
Molecular Weight | 353.41 |
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Solubility | Solubility (25°C) In vitro DMSO: 70 mg/mL (198.07 mM); Water: Insoluble; Ethanol: Insoluble; |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
RIDADR | NONHforallmodesoftransport |
1. Astudillo L, Da Silva TG, Wang Z, Han X, Jin K, VanWye J, Zhu X, Weaver K, Oashi T, Lopes PE et al.. (2016) The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis.. Cancer Res, 76 (12): (3593-603). [PMID:27197169] [10.1021/op500134e] |