IMR-1 - 99%, high purity , CAS No.310456-65-6, Inhibitor of notch receptor 1

Item Number
I413960
Grouped product items
SKUSizeAvailabilityPrice Qty
I413960-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
I413960-10mg
10mg
In stock
$102.90
I413960-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$231.90
I413960-50mg
50mg
In stock
$412.90
I413960-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$685.90

Notch Inhibitors

Basic Description

Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsIMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 26 μM.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of notch receptor 1
Product Description

Information

IMR-1 IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 26 μM.


Targets

Notch (Cell-free assay) 26 μM


Cell Research(from reference)

Cell lines:OE33 and 786-0 cells 

Concentrations:5, 10, 15, 25 μM 

Associated Targets(Human)

NOTCH1 Tchem Neurogenic locus notch homolog protein 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name ethyl 2-[2-methoxy-4-[(E)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetate
INCHI InChI=1S/C15H15NO5S2/c1-3-20-13(17)8-21-10-5-4-9(6-11(10)19-2)7-12-14(18)16-15(22)23-12/h4-7H,3,8H2,1-2H3,(H,16,18,22)/b12-7+
InChi Key QHPJWPQRZMBKTG-KPKJPENVSA-N
Canonical SMILES CCOC(=O)COC1=C(C=C(C=C1)C=C2C(=O)NC(=S)S2)OC
Isomeric SMILES CCOC(=O)COC1=C(C=C(C=C1)/C=C/2\C(=O)NC(=S)S2)OC
PubChem CID 1246059
Molecular Weight 353.41

Certificates

Certificate of Analysis(COA)

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2 results found

Lot NumberCertificate TypeDateItem
H2213340Certificate of AnalysisJun 13, 2022 I413960
H2213356Certificate of AnalysisJun 13, 2022 I413960

Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 70 mg/mL (198.07 mM); Water: Insoluble; Ethanol: Insoluble;

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

RIDADR NONHforallmodesoftransport

Related Documents

References

1. Astudillo L, Da Silva TG, Wang Z, Han X, Jin K, VanWye J, Zhu X, Weaver K, Oashi T, Lopes PE et al..  (2016)  The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis..  Cancer Res,  76  (12): (3593-603).  [PMID:27197169] [10.1021/op500134e]

Solution Calculators