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IMR-1 , CAS No.I611048, Inhibitor of notch receptor 1

Item Number

I611048

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SKU	Size	Availability	Price	Qty
I611048-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
I611048-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Basic Description

NOTCH1 Tchem Neurogenic locus notch homolog protein 1 (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	ethyl 2-[2-methoxy-4-[(E)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetate
INCHI	InChI=1S/C15H15NO5S2/c1-3-20-13(17)8-21-10-5-4-9(6-11(10)19-2)7-12-14(18)16-15(22)23-12/h4-7H,3,8H2,1-2H3,(H,16,18,22)/b12-7+
InChi Key	QHPJWPQRZMBKTG-KPKJPENVSA-N
Canonical SMILES	CCOC(=O)COc1ccc(cc1OC)/C=C\1/SC(=S)NC1=O
Isomeric SMILES	CCOC(=O)COC1=C(C=C(C=C1)/C=C/2\C(=O)NC(=S)S2)OC
PubChem CID	1246059

PubChem CID	1246059

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1. Astudillo L, Da Silva TG, Wang Z, Han X, Jin K, VanWye J, Zhu X, Weaver K, Oashi T, Lopes PE et al.. (2016) The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis.. Cancer Res, 76 (12): (3593-603). [PMID:27197169] [10.1021/op500134e]

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