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INCB024360 analogue - 10mM in DMSO, high purity , CAS No.914471-09-3
Potent indoleamine 2,3-dioxygenase (IDO) inhibitor
Basic Description Synonyms 914471-09-3 | INCB024360 | IDO5L | 4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide | INCB14943 | 4-Amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide | CHEMBL584991 | 4-Amino-N-(3-chloro-4-fluorophenyl)-N'- Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50values are 19 and 67 nM in enzymatic activity and HeLa cell assays, respectively). Decreases kynurenine levels in plasma and reduces tumor growthin vivo. Cell membrane permeable. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description INCB024360 analogue is a potent, competitive IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with IC50 of 67 nM
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 4-amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide INCHI InChI=1S/C9H7ClFN5O2/c10-5-3-4(1-2-6(5)11)13-9(14-17)7-8(12)16-18-15-7/h1-3,17H,(H2,12,16)(H,13,14) InChi Key HGXSLPIXNPASGZ-UHFFFAOYSA-N Canonical SMILES C1=CC(=C(C=C1N=C(C2=NON=C2N)NO)Cl)F Isomeric SMILES C1=CC(=C(C=C1N=C(C2=NON=C2N)NO)Cl)F PubChem CID 135424953 Molecular Weight 271.64
Chemical and Physical Properties Refractive Index 1.72 Boil Point(°C) ~318.6 °C at 760 mmHg Melt Point(°C) 154.74°C
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