Suppress carcinogenesis at the initial stage. It has been proved that it can inhibit the occurrence of cancer in several animals, but it will increase the incidence of cancer if it is administered at the post-onset stage. Found in cruciferous vegetables.
Storage Temp
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of Aryl hydrocarbon receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Indole-3-carbinol is a novel secondary plant metabolite produced in cruciferous vegetables, such as cabbage, cauliflower and brussels sprouts.
1.Aggarwal BB, Ichikawa H. (2005) Molecular targets and anticancer potential of indole-3-carbinol and its derivatives.. Cell Cycle, 4 (9):(1201-15). [PMID:16082211]
2.Bjeldanes LF, Kim JY, Grose KR, Bartholomew JC, Bradfield CA. (1991) Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.. Proc Natl Acad Sci USA, 88 (21):(9543-7). [PMID:1658785]
3.Rogan EG. (2006) The natural chemopreventive compound indole-3-carbinol: state of the science.. In Vivo, 20 (2):(221-8). [PMID:16634522]
4.Metidji A, Omenetti S, Crotta S, Li Y, Nye E, Ross E, Li V, Maradana MR, Schiering C, Stockinger B. (2018) The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity.. Immunity, 49 (2):(353-362.e5). [PMID:30119997]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
D2017020