Suppress carcinogenesis at the initial stage. It has been proved that it can inhibit the occurrence of cancer in several animals, but it will increase the incidence of cancer if it is administered at the post-onset stage. Found in cruciferous vegetables.
Storage Temp
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of Aryl hydrocarbon receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Indole-3-carbinol is a novel secondary plant metabolite produced in cruciferous vegetables, such as cabbage, cauliflower and brussels sprouts.
1.Wenxiu Zheng, Wenhao Wang, Desheng Fu, Tianyu Zhang, Zhengrui Liang, Ling Yan, Changhong Liu, Lei Zheng. (2023) Microwave bag cooking affects the quality, glucosinolates content and hydrolysate production of broccoli florets. FOOD RESEARCH INTERNATIONAL, 164 (112401). [PMID:36738020][10.1016/j.foodres.2022.112401]
2.Wenxiu Zheng, Lin Ren, Wenzhuo Hao, Lei Wang, Changhong Liu, Lei Zheng. (2022) Encapsulation of indole-3-carbinol in Pickering emulsions stabilized by OSA-modified high amylose corn starch: Preparation, characterization and storage stability properties. FOOD CHEMISTRY, 386 (132846). [PMID:35381538][10.1016/j.foodchem.2022.132846]
3.Jia Cheng Qian, Dan Liu, Li Ping Lin, Wen Jing Zhu, Ren Xiang Tan. (2022) Minor bioactive indoles from kimchi mirror the regioselectivity in indole-3-carbinol oligomerization. FOOD CHEMISTRY, 382 (132571). [PMID:35245758][10.1016/j.foodchem.2022.132571]
4.Wen Jing Zhu, Li Ping Lin, Dan Liu, Jia Cheng Qian, Bei Bei Zhou, Dan Dan Yuan, Ren Xiang Tan. (2021) Pharmacophore-inspired discovery of FLT3 inhibitor from kimchi. FOOD CHEMISTRY, 361 (130139). [PMID:34062461][10.1016/j.foodchem.2021.130139]
5.Xu Yu,Fei Ma,Liangxiao Zhang,Peiwu Li. (2020-05-08) Extraction and Quantification of Sulforaphane and Indole-3-Carbinol from Rapeseed Tissues Using QuEChERS Coupled with UHPLC-MS/MS.. Molecules (Basel, Switzerland), 25 ((9)):[PMID:32375365]
References
1.Aggarwal BB, Ichikawa H. (2005) Molecular targets and anticancer potential of indole-3-carbinol and its derivatives.. Cell Cycle, 4 (9):(1201-15). [PMID:16082211][10.1021/op500134e]
2.Bjeldanes LF, Kim JY, Grose KR, Bartholomew JC, Bradfield CA. (1991) Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.. Proc Natl Acad Sci USA, 88 (21):(9543-7). [PMID:1658785][10.1021/op500134e]
3.Rogan EG. (2006) The natural chemopreventive compound indole-3-carbinol: state of the science.. In Vivo, 20 (2):(221-8). [PMID:16634522][10.1021/op500134e]
4.Metidji A, Omenetti S, Crotta S, Li Y, Nye E, Ross E, Li V, Maradana MR, Schiering C, Stockinger B. (2018) The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity.. Immunity, 49 (2):(353-362.e5). [PMID:30119997][10.1016/j.immuni.2018.07.010]
5.Wenxiu Zheng, Wenhao Wang, Desheng Fu, Tianyu Zhang, Zhengrui Liang, Ling Yan, Changhong Liu, Lei Zheng. (2023) Microwave bag cooking affects the quality, glucosinolates content and hydrolysate production of broccoli florets. FOOD RESEARCH INTERNATIONAL, 164 (112401). [PMID:36738020][10.1016/j.foodres.2022.112401]
6.Wenxiu Zheng, Lin Ren, Wenzhuo Hao, Lei Wang, Changhong Liu, Lei Zheng. (2022) Encapsulation of indole-3-carbinol in Pickering emulsions stabilized by OSA-modified high amylose corn starch: Preparation, characterization and storage stability properties. FOOD CHEMISTRY, 386 (132846). [PMID:35381538][10.1016/j.foodchem.2022.132846]
7.Jia Cheng Qian, Dan Liu, Li Ping Lin, Wen Jing Zhu, Ren Xiang Tan. (2022) Minor bioactive indoles from kimchi mirror the regioselectivity in indole-3-carbinol oligomerization. FOOD CHEMISTRY, 382 (132571). [PMID:35245758][10.1016/j.foodchem.2022.132571]
8.Wen Jing Zhu, Li Ping Lin, Dan Liu, Jia Cheng Qian, Bei Bei Zhou, Dan Dan Yuan, Ren Xiang Tan. (2021) Pharmacophore-inspired discovery of FLT3 inhibitor from kimchi. FOOD CHEMISTRY, 361 (130139). [PMID:34062461][10.1016/j.foodchem.2021.130139]
9.Xu Yu,Fei Ma,Liangxiao Zhang,Peiwu Li. (2020-05-08) Extraction and Quantification of Sulforaphane and Indole-3-Carbinol from Rapeseed Tissues Using QuEChERS Coupled with UHPLC-MS/MS.. Molecules (Basel, Switzerland), 25 ((9)):[PMID:32375365]
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