DL-Indole-3-lactic Acid is used as a reagent in the synthesis of 2-hydroxy-1-(1H-indol-3-yl)-4-methylpentan-3-one which has weak antibacterial activity against 16 bacterial strains, including Escherichia coli, Bacillus subtilis and Staphylococcus aureus. DL-Indole-3-lactic Acid is also used in the preparation of Monatin, a natural sweet peptidomimetic.
1.Pan Hu, Xin Yan, Yijia Zeng, Zherui Jiang, Juan Liu, Wu-wen Feng. (2023) An UPLC-MS/MS method for targeted analysis of microbial and host tryptophan metabolism after administration of polysaccharides from Atractylodes macrocephala Koidz. in ulcerative colitis mice. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 235 (115585). [PMID:37523866]
2.Qixing Nie, Yonggan Sun, Mingzhi Li, Sheng Zuo, Chunhua Chen, Qiongni Lin, Shaoping Nie. (2023) Targeted modification of gut microbiota and related metabolites via dietary fiber. CARBOHYDRATE POLYMERS, 316 (120986). [PMID:37321707]
3.Qingqing Zhang, Qing Zhao, Tao Li, Longya Lu, Fei Wang, Hong Zhang, Zhi Liu, Huihui Ma, Qihui Zhu, Jingjing Wang, Xuemei Zhang, Yang Pei, Qisha Liu, Yuyu Xu, Jinlong Qie, Xiaoting Luan, Zhibin Hu, Xingyin Liu. (2023) Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity. Cell Metabolism, 35 (943-960.e9). [PMID:37192617]
4.Minzhen Xie, Siqi Gu, Yang Hong, Yan Liu, Xiaohui Rong, Wanying Lu, Heng Liu, Adnan Mohammed Algradi, Anam Naseem, ZunPeng Shu, Qi Wang. (2023) Study on the mechanism of Coptis chinensis Franch. And its main active components in treating Alzheimer's disease based on SCFAs using Orbitrap Fusion Lumos Tribrid MS. JOURNAL OF ETHNOPHARMACOLOGY, 311 (116392). [PMID:37028611]
5.Zhou Ziyuan, Wang Baohong, Pan Xiaxia, Lv Jiawen, Lou Zhuoqi, Han Yuqiu, Yao Yuanyuan, Chen Jun, Wang Qiangqiang, Li Lanjuan. (2023) Microbial metabolites indole derivatives sensitize mice to D-GalN/LPS induced-acute liver failure via the Tlr2/NF-κB pathway. Frontiers in Microbiology, 13 [PMID:36687651]
6.Mengmeng Song, Xianjie Sheng, Genyi Ye, Zhuicheng Xu, Xinru Li, Tong Xie, Haishan Deng, An Kang. (2022) Selective enrichment of microbiota-derived tryptophan metabolites in mouse faeces based on molecularly imprinted solid-phase extraction for HPLC analysis. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 212 (114641). [PMID:35182828]
References
1.Pan Hu, Xin Yan, Yijia Zeng, Zherui Jiang, Juan Liu, Wu-wen Feng. (2023) An UPLC-MS/MS method for targeted analysis of microbial and host tryptophan metabolism after administration of polysaccharides from Atractylodes macrocephala Koidz. in ulcerative colitis mice. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 235 (115585). [PMID:37523866]
2.Qixing Nie, Yonggan Sun, Mingzhi Li, Sheng Zuo, Chunhua Chen, Qiongni Lin, Shaoping Nie. (2023) Targeted modification of gut microbiota and related metabolites via dietary fiber. CARBOHYDRATE POLYMERS, 316 (120986). [PMID:37321707]
3.Qingqing Zhang, Qing Zhao, Tao Li, Longya Lu, Fei Wang, Hong Zhang, Zhi Liu, Huihui Ma, Qihui Zhu, Jingjing Wang, Xuemei Zhang, Yang Pei, Qisha Liu, Yuyu Xu, Jinlong Qie, Xiaoting Luan, Zhibin Hu, Xingyin Liu. (2023) Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity. Cell Metabolism, 35 (943-960.e9). [PMID:37192617]
4.Minzhen Xie, Siqi Gu, Yang Hong, Yan Liu, Xiaohui Rong, Wanying Lu, Heng Liu, Adnan Mohammed Algradi, Anam Naseem, ZunPeng Shu, Qi Wang. (2023) Study on the mechanism of Coptis chinensis Franch. And its main active components in treating Alzheimer's disease based on SCFAs using Orbitrap Fusion Lumos Tribrid MS. JOURNAL OF ETHNOPHARMACOLOGY, 311 (116392). [PMID:37028611]
5.Zhou Ziyuan, Wang Baohong, Pan Xiaxia, Lv Jiawen, Lou Zhuoqi, Han Yuqiu, Yao Yuanyuan, Chen Jun, Wang Qiangqiang, Li Lanjuan. (2023) Microbial metabolites indole derivatives sensitize mice to D-GalN/LPS induced-acute liver failure via the Tlr2/NF-κB pathway. Frontiers in Microbiology, 13 [PMID:36687651]
6.Mengmeng Song, Xianjie Sheng, Genyi Ye, Zhuicheng Xu, Xinru Li, Tong Xie, Haishan Deng, An Kang. (2022) Selective enrichment of microbiota-derived tryptophan metabolites in mouse faeces based on molecularly imprinted solid-phase extraction for HPLC analysis. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 212 (114641). [PMID:35182828]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
A2403404