Indomethacin - 99%, high purity , CAS No.53-86-1, Inhibitor of COX-1;Inhibitor of COX-2;Agonist of DP 2 receptor;Agonist of Peroxisome proliferator-activated receptor-γ;Inhibitor of Proton-coupled folate transporter

34 Citations
Item Number
I106885
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500g
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Non-selective COX inhibitor

Basic Description

Synonyms1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid | 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1h-indol-3-yl}acetic acid | Miametan | Indameth | Indomethazine | (1-p-Chlorobenzoyl-5-methoxy-2-methylindol-3-yl)acetic acid | Methazine |
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsNon-selective COX inhibitor (IC 50 = 230 and 630 nM for human COX-1 and COX-2, respectively). Activates PPARα and PPARγ (EC 50 = 40 nM).
Shipped InNormal
GradeMoligand™
Action TypeAGONIST, INHIBITOR
Mechanism of actionInhibitor of COX-1;Inhibitor of COX-2;Agonist of DP 2 receptor;Agonist of Peroxisome proliferator-activated receptor-γ;Inhibitor of Proton-coupled folate transporter
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Indomethacin is an inhibitor of the enzyme cyclooxygenase 1 and 2. Indomethacin elicits side effects in gastrointestinal tract, kidney and cerebrum. Indomethacin, along with ibuprofen, is effective for treating patent ductus arteriosus (PDA) in infants with respiratory distress syndrome. Rectal indomethacin is effective in treating endoscopic retrograde cholangiography (ERCP) induced pancreatitis
Indomethacin has been used: · as a medium supplement in osteogenic and adipogenic differentiation assays in human bone marrow stem cells · as a medium supplement in bovine amniotic fluid stem cells (BAFSCs) culture · in the inhibition of prostaglandin E2 (PGE2) in T cells

Product Properties

ALogP4.3

Associated Targets(Human)

MT-CO2 Tchem Cytochrome c oxidase subunit 2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TBXAS1 Tchem Thromboxane-A synthase (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NAPRT Tchem Nicotinate phosphoribosyltransferase (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGS1 Tclin Prostaglandin G/H synthase 1 (60 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC46A1 Tchem Proton-coupled folate transporter (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGDR2 Tchem Prostaglandin D2 receptor 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGS2 Tclin Prostaglandin G/H synthase 2 (66 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
AKR1C3 Tchem Aldo-keto reductase family 1 member C3 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALB Tchem Serum albumin (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
AR Tclin Androgen receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PPARG Tclin Peroxisome proliferator-activated receptor gamma (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CXCL8 Tchem Interleukin-8 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
INSR Tclin Insulin receptor (5558 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGFR Tclin Prostanoid FP receptor (687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

PLA2G1B Phospholipase A2 group 1B (227 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
blaZ Beta-lactamase (285 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Alpha-chymotrypsin (819 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Glo1 Glyoxalase I (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Fdft1 Squalene synthetase (34 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sigmar1 Sigma opioid receptor (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGES Prostaglandin E synthase (10 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cruzipain (33337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ntsr1 Neurotensin receptor 1 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bdkrb1 Bradykinin B1 receptor (77 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcc1 Multidrug resistance-associated protein 1 (42 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ppard Peroxisome proliferator-activated receptor delta (358 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ptgds Prostaglandin-H2 D-isomerase (67 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pneumocystis carinii (749 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania infantum (5912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei (78846 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei brucei (13300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Entamoeba histolytica (2676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptosporidium parvum (1150 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania amazonensis (3813 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania donovani (89745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania major (2877 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania mexicana (936 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma cruzi (99888 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichomonas vaginalis (2376 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Toxoplasma gondii (4585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cavia porcellus (23802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bos taurus (956 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Oryctolagus cuniculus (11301 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei rhodesiense (7991 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COS-7 (515 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
H9c2 (3506 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
J774.A1 (2436 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488179784
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179784
IUPAC Name 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
INCHI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
InChi Key CGIGDMFJXJATDK-UHFFFAOYSA-N
Canonical SMILES CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O
Isomeric SMILES CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O
WGK Germany 3
RTECS NL3500000
PubChem CID 3715
UN Number 2811
Packing Group I
Molecular Weight 357.79
Beilstein 497341
Reaxy-Rn 497341

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot NumberCertificate TypeDateItem
B2310588Certificate of AnalysisFeb 16, 2023 I106885
B2310583Certificate of AnalysisFeb 16, 2023 I106885
B2310584Certificate of AnalysisFeb 16, 2023 I106885
D2320054Certificate of AnalysisJun 23, 2022 I106885
I2202359Certificate of AnalysisJun 23, 2022 I106885
I2202360Certificate of AnalysisJun 23, 2022 I106885
I2202361Certificate of AnalysisJun 23, 2022 I106885
I2202362Certificate of AnalysisJun 23, 2022 I106885
L2301081Certificate of AnalysisJun 23, 2022 I106885

Chemical and Physical Properties

SolubilitySoluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insolu
SensitivityLight sensitive
Melt Point(°C)158-162°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08,   GHS05,   GHS07
Signal Danger
Hazard Statements

H335:May cause respiratory irritation

H301:Toxic if swallowed

H373:Causes damage to organs through prolonged or repeated exposure

H413:May cause long lasting harmful effects to aquatic life

H318:Causes serious eye damage

H317:May cause an allergic skin reaction

H336:May cause drowsiness or dizziness

H300:Fatal if swallowed

H360:May damage fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.

P318:if exposed or concerned, get medical advice.

P317:Get emergency medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS NL3500000
Reaxy-Rn 497341
Class 6.1
Merck Index 4968

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13. Xi Hu, Yu Sun, Xiaoqi Zhou, Bo Zhang, Hanxi Guan, Fan Xia, Shuangying Gui, Xueqian Kong, Fangyuan Li, Daishun Ling.  (2022)  Insight into Drug Loading Regulated Micellar Rigidity by Nuclear Magnetic Resonance.  ACS Nano,  16  (12): (21407–21416).  [PMID:36375116]
14. Jinhuang Shen, Xinhua Ma, Yubin He, Yanjun Wang, Tianhua Zhong, Yonghong Zhang.  (2022)  Anti-inflammatory and anti-oxidant properties of Melianodiol on DSS-induced ulcerative colitis in mice.  PeerJ,  10  (e14209).  [PMID:36312760]
15. Yuhan Yang, Yangyi Chen, Dianpeng Li, Shiyuan Lin, Hui Chen, Wei Wu, Wei Zhang.  (2023)  Linolenic acid conjugated chitosan micelles for improving the oral absorption of doxorubicin via fatty acid transporter.  CARBOHYDRATE POLYMERS,  300  (120233).  [PMID:36372473]
16. Minxian Zhang, Xuecong Lin, Ziran Yi, Xiang Xu, Jingling Yang, Mingshan Zhu.  (2023)  Enhanced reactive oxidation species generation by ligand-to-metal-charge transfer between oxygen vacancy-rich ZnO mesocrystal with ciprofloxacin pollutants.  APPLIED CATALYSIS B-ENVIRONMENTAL,  321  (122033).  [PMID:]
17. Huixia Feng, Guilin Chen, Yongli Zhang, Mingquan Guo.  (2022)  Potential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2.  Journal of Inflammation Research,  15  ( 4677–4692).  [PMID:35996684]
18. Fangwei Yang, Cheng Wang, Hang Yu, Yahui Guo, Yuliang Cheng, Weirong Yao, Yunfei Xie.  (2022)  Establishment of the thin-layer chromatography-surface-enhanced Raman spectroscopy and chemometrics method for simultaneous identification of eleven illegal drugs in anti-rheumatic health food.  Food Bioscience,  49  (101842).  [PMID:]
19. Yingfei Wang, Junhui Zhou, Fengliang Wang, Yi Xie, Shengwei Liu, Zhimin Ao, Chuanhao Li.  (2022)  Hydrogen generation from photocatalytic treatment of wastewater containing pharmaceuticals and personal care products by Oxygen-doped crystalline carbon nitride.  SEPARATION AND PURIFICATION TECHNOLOGY,  296  (121425).  [PMID:]
20. Yue Liu, Hu Li, Ruigang Wang, Qian Hu, Ying Zhang, Zhanhui Wang, Jian Zhou, Guangzhou Qu, Tiecheng Wang, Hanzhong Jia, Lingyan Zhu.  (2022)  Underlying mechanisms of promoted formation of haloacetic acids disinfection byproducts after indometacin degradation by non-thermal discharge plasma.  WATER RESEARCH,  220  (118701).  [PMID:35667169]
21. Jiankun Cao, Huayin Zhang, Qixun Nian, Qian Xu.  (2022)  Electrospun chitosan/polyethylene oxide nanofibers mat loaded with copper (II) as a new sensor for colorimetric detection of tetracycline.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  212  (527).  [PMID:35580746]
22. Fenglei Zhang, Xuejing Pei, Xiaoxia Peng, Dongxia Gou, Xiao Fan, Xuefei Zheng, Chengcheng Song, Yifa Zhou, Sisi Cui.  (2022)  Dual crosslinking of folic acid-modified pectin nanoparticles for enhanced oral insulin delivery.  Biomaterials Advances,  135  (212746).  [PMID:35929218]
23. Yuehua Deng, Wenhao Deng, Wenquan Huang, Zhiyong Zheng, Rui Zhang, Shiyuan Liu, Yanbin Jiang.  (2022)  Norfloxacin co-amorphous salt systems: Effects of molecular descriptors on the formation and physical stability of co-amorphous systems.  CHEMICAL ENGINEERING SCIENCE,  253  (117549).  [PMID:]
24. Yu Zou, Quan Zhou, Yinan Zhao, Defu Zhi, Huiying Chen, Rui Wang, Benzhi Ju, Shubiao Zhang.  (2022)  Structure–activity relationships of pH-responsive and ionizable lipids for gene delivery.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  617  (121596).  [PMID:35181463]
25. Jiahui Chen, Minshan Guo, Runhui Fan, Yayun Peng, Ting Cai.  (2022)  Impact of bile salt on solution-mediated phase transformation of pharmaceutical cocrystals: The importance of coformer release kinetics.  CHEMICAL ENGINEERING JOURNAL,  435  (134928).  [PMID:]
26. Li-Juan Lang, Min Wang, Chang Lei, Yi Shen, Qi-Jie Zhu, Hong-Mei Diao, Hao Chen, Lei Shen, Xiang Dong, Bei Jiang, Chao-Jiang Xiao.  (2022)  Phloridzin Highly Accumulated in Malus rockii Rehder and Its Structure Revision and Hypolipidemic Activity.  PLANTA MEDICA,  88  (13): (1190-1198).  [PMID:34875697]
27. Yanbei Tu, Lihua Tan, Tao Lu, Kai Wang, Haiyong Wang, Bing Han, Yuxin Zhao, Hanbin Chen, Yanfang Li, Haixia Chen, Meiwan Chen, Chengwei He.  (2022)  Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.  BIOCHEMICAL PHARMACOLOGY,  197  (114912).  [PMID:35032460]
28. Feng Huixia, Chen Guilin, Zhang Yongli, Guo Mingquan.  (2021)  Exploring Multifunctional Bioactive Components from Podophyllum sinense Using Multi-Target Ultrafiltration.  Frontiers in Pharmacology,  12    [PMID:34759823]
29. Yang Shirui, Zhang Wenxiang, Liu Zheyi, Zhai Ziyang, Hou Xudong, Wang Ping, Ge Guangbo, Wang Fangjun.  (2021)  Lysine reactivity profiling reveals molecular insights into human serum albumin–small-molecule drug interactions.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  413  (30): (7431-7440).  [PMID:34676431]
30. Wang Shihai, Zhou Yu, Tao Wangwang, Liu Jingyi, Chen Hongxiang, Zhao Zuyi.  (2022)  Fe3O4-modified amphiphilic polyurethane nanoparticles with good stability as magnetic-targeted drug carriers.  POLYMER BULLETIN,  79  (10): (8617-8631).  [PMID:]
31. Tao Lijun, Chen Lina, Pei Yanmin, Ma Ping, Xu Qingbin, Wang Jialing, Yu Yang, Cheng Jiang, Zhou Ru.  (2021)  Vasodilatory effects of betaine on isolated rat pulmonary artery rings.  PHARMAZIE,  76  (10): (499-502).  [PMID:34620278]
32. Qing Wang,Mao Ye,Li Xu,Zhi-guo Shi.  (2015-09-01)  A reversed-phase/hydrophilic interaction mixed-mode C18-Diol stationary phase for multiple applications..  Analytica chimica acta,  888  (182-190).  [PMID:26320974]
33. Chaonan Huang,Yun Li,Jiajia Yang,Junyu Peng,Jun Tan,Yun Fan,Longxing Wang,Jiping Chen.  (2018-09-03)  Hyperbranched mixed-mode anion-exchange polymeric sorbent for highly selective extraction of nine acidic non-steroidal anti-inflammatory drugs from human urine..  Talanta,  190  (15-22).  [PMID:30172492]
34. Xiaofei Han,Jia Chen,Zhan Li,Kaijun Quan,Hongdeng Qiu.  (2020-09-07)  Magnetic solid-phase extraction of triazole fungicides based on magnetic porous carbon prepared by combustion combined with solvothermal method..  Analytica chimica acta,  1129  (85-97).  [PMID:32891394]

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17. Huixia Feng, Guilin Chen, Yongli Zhang, Mingquan Guo.  (2022)  Potential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2.  Journal of Inflammation Research,  15  ( 4677–4692).  [PMID:35996684]
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19. Yingfei Wang, Junhui Zhou, Fengliang Wang, Yi Xie, Shengwei Liu, Zhimin Ao, Chuanhao Li.  (2022)  Hydrogen generation from photocatalytic treatment of wastewater containing pharmaceuticals and personal care products by Oxygen-doped crystalline carbon nitride.  SEPARATION AND PURIFICATION TECHNOLOGY,  296  (121425).  [PMID:]
20. Yue Liu, Hu Li, Ruigang Wang, Qian Hu, Ying Zhang, Zhanhui Wang, Jian Zhou, Guangzhou Qu, Tiecheng Wang, Hanzhong Jia, Lingyan Zhu.  (2022)  Underlying mechanisms of promoted formation of haloacetic acids disinfection byproducts after indometacin degradation by non-thermal discharge plasma.  WATER RESEARCH,  220  (118701).  [PMID:35667169]
21. Jiankun Cao, Huayin Zhang, Qixun Nian, Qian Xu.  (2022)  Electrospun chitosan/polyethylene oxide nanofibers mat loaded with copper (II) as a new sensor for colorimetric detection of tetracycline.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  212  (527).  [PMID:35580746]
22. Fenglei Zhang, Xuejing Pei, Xiaoxia Peng, Dongxia Gou, Xiao Fan, Xuefei Zheng, Chengcheng Song, Yifa Zhou, Sisi Cui.  (2022)  Dual crosslinking of folic acid-modified pectin nanoparticles for enhanced oral insulin delivery.  Biomaterials Advances,  135  (212746).  [PMID:35929218]
23. Yuehua Deng, Wenhao Deng, Wenquan Huang, Zhiyong Zheng, Rui Zhang, Shiyuan Liu, Yanbin Jiang.  (2022)  Norfloxacin co-amorphous salt systems: Effects of molecular descriptors on the formation and physical stability of co-amorphous systems.  CHEMICAL ENGINEERING SCIENCE,  253  (117549).  [PMID:]
24. Yu Zou, Quan Zhou, Yinan Zhao, Defu Zhi, Huiying Chen, Rui Wang, Benzhi Ju, Shubiao Zhang.  (2022)  Structure–activity relationships of pH-responsive and ionizable lipids for gene delivery.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  617  (121596).  [PMID:35181463]
25. Jiahui Chen, Minshan Guo, Runhui Fan, Yayun Peng, Ting Cai.  (2022)  Impact of bile salt on solution-mediated phase transformation of pharmaceutical cocrystals: The importance of coformer release kinetics.  CHEMICAL ENGINEERING JOURNAL,  435  (134928).  [PMID:]
26. Li-Juan Lang, Min Wang, Chang Lei, Yi Shen, Qi-Jie Zhu, Hong-Mei Diao, Hao Chen, Lei Shen, Xiang Dong, Bei Jiang, Chao-Jiang Xiao.  (2022)  Phloridzin Highly Accumulated in Malus rockii Rehder and Its Structure Revision and Hypolipidemic Activity.  PLANTA MEDICA,  88  (13): (1190-1198).  [PMID:34875697]
27. Yanbei Tu, Lihua Tan, Tao Lu, Kai Wang, Haiyong Wang, Bing Han, Yuxin Zhao, Hanbin Chen, Yanfang Li, Haixia Chen, Meiwan Chen, Chengwei He.  (2022)  Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.  BIOCHEMICAL PHARMACOLOGY,  197  (114912).  [PMID:35032460]
28. Feng Huixia, Chen Guilin, Zhang Yongli, Guo Mingquan.  (2021)  Exploring Multifunctional Bioactive Components from Podophyllum sinense Using Multi-Target Ultrafiltration.  Frontiers in Pharmacology,  12    [PMID:34759823]
29. Yang Shirui, Zhang Wenxiang, Liu Zheyi, Zhai Ziyang, Hou Xudong, Wang Ping, Ge Guangbo, Wang Fangjun.  (2021)  Lysine reactivity profiling reveals molecular insights into human serum albumin–small-molecule drug interactions.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  413  (30): (7431-7440).  [PMID:34676431]
30. Wang Shihai, Zhou Yu, Tao Wangwang, Liu Jingyi, Chen Hongxiang, Zhao Zuyi.  (2022)  Fe3O4-modified amphiphilic polyurethane nanoparticles with good stability as magnetic-targeted drug carriers.  POLYMER BULLETIN,  79  (10): (8617-8631).  [PMID:]
31. Tao Lijun, Chen Lina, Pei Yanmin, Ma Ping, Xu Qingbin, Wang Jialing, Yu Yang, Cheng Jiang, Zhou Ru.  (2021)  Vasodilatory effects of betaine on isolated rat pulmonary artery rings.  PHARMAZIE,  76  (10): (499-502).  [PMID:34620278]
32. Qing Wang,Mao Ye,Li Xu,Zhi-guo Shi.  (2015-09-01)  A reversed-phase/hydrophilic interaction mixed-mode C18-Diol stationary phase for multiple applications..  Analytica chimica acta,  888  (182-190).  [PMID:26320974]
33. Chaonan Huang,Yun Li,Jiajia Yang,Junyu Peng,Jun Tan,Yun Fan,Longxing Wang,Jiping Chen.  (2018-09-03)  Hyperbranched mixed-mode anion-exchange polymeric sorbent for highly selective extraction of nine acidic non-steroidal anti-inflammatory drugs from human urine..  Talanta,  190  (15-22).  [PMID:30172492]
34. Xiaofei Han,Jia Chen,Zhan Li,Kaijun Quan,Hongdeng Qiu.  (2020-09-07)  Magnetic solid-phase extraction of triazole fungicides based on magnetic porous carbon prepared by combustion combined with solvothermal method..  Analytica chimica acta,  1129  (85-97).  [PMID:32891394]

Solution Calculators