Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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I106885-5g | 5g | In stock | $103.90 | |
I106885-25g | 25g | In stock | $468.90 | |
I106885-100g | 100g | In stock | $1,684.90 | |
I106885-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $7,581.90 |
Non-selective COX inhibitor
Synonyms | 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid | 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1h-indol-3-yl}acetic acid | Miametan | Indameth | Indomethazine | (1-p-Chlorobenzoyl-5-methoxy-2-methylindol-3-yl)acetic acid | Methazine | |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Non-selective COX inhibitor (IC 50 = 230 and 630 nM for human COX-1 and COX-2, respectively). Activates PPARα and PPARγ (EC 50 = 40 nM). |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | AGONIST, INHIBITOR |
Mechanism of action | Inhibitor of COX-1;Inhibitor of COX-2;Agonist of DP 2 receptor;Agonist of Peroxisome proliferator-activated receptor-γ;Inhibitor of Proton-coupled folate transporter |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Indomethacin is an inhibitor of the enzyme cyclooxygenase 1 and 2. Indomethacin elicits side effects in gastrointestinal tract, kidney and cerebrum. Indomethacin, along with ibuprofen, is effective for treating patent ductus arteriosus (PDA) in infants with respiratory distress syndrome. Rectal indomethacin is effective in treating endoscopic retrograde cholangiography (ERCP) induced pancreatitis |
ALogP | 4.3 |
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Pubchem Sid | 488179784 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179784 |
IUPAC Name | 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid |
INCHI | InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23) |
InChi Key | CGIGDMFJXJATDK-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O |
Isomeric SMILES | CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O |
WGK Germany | 3 |
RTECS | NL3500000 |
PubChem CID | 3715 |
UN Number | 2811 |
Packing Group | I |
Molecular Weight | 357.79 |
Beilstein | 497341 |
Reaxy-Rn | 497341 |
PubChem CID | 3715 |
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DrugBank Ligand | DB00328 |
CAS Registry No. | 53-86-1 |
ChEBI | CHEBI:49662 |
Wikipedia | Indometacin |
ChEMBL Ligand | CHEMBL6 |
BindingDB Ligand | 17638 |
RCSB PDB Ligand | IMN |
PEP | indomethacin |
DrugCentral Ligand | 1440 |
GPCRdb Ligand | indomethacin |
PubChem SID | 488179784 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
B2310588 | Certificate of Analysis | Feb 16, 2023 | I106885 |
B2310583 | Certificate of Analysis | Feb 16, 2023 | I106885 |
B2310584 | Certificate of Analysis | Feb 16, 2023 | I106885 |
D2320054 | Certificate of Analysis | Jun 23, 2022 | I106885 |
I2202359 | Certificate of Analysis | Jun 23, 2022 | I106885 |
I2202360 | Certificate of Analysis | Jun 23, 2022 | I106885 |
I2202361 | Certificate of Analysis | Jun 23, 2022 | I106885 |
I2202362 | Certificate of Analysis | Jun 23, 2022 | I106885 |
L2301081 | Certificate of Analysis | Jun 23, 2022 | I106885 |
Solubility | Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insolu |
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Sensitivity | Light sensitive |
Melt Point(°C) | 158-162°C |
Pictogram(s) | GHS06, GHS08, GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H335:May cause respiratory irritation H301:Toxic if swallowed H373:Causes damage to organs through prolonged or repeated exposure H413:May cause long lasting harmful effects to aquatic life H318:Causes serious eye damage H317:May cause an allergic skin reaction H336:May cause drowsiness or dizziness H300:Fatal if swallowed H360:May damage fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | NL3500000 |
Reaxy-Rn | 497341 |
Class | 6.1 |
Merck Index | 4968 |
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24. Yu Zou, Quan Zhou, Yinan Zhao, Defu Zhi, Huiying Chen, Rui Wang, Benzhi Ju, Shubiao Zhang. (2022) Structure–activity relationships of pH-responsive and ionizable lipids for gene delivery. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 617 (121596). [PMID:35181463] |
25. Jiahui Chen, Minshan Guo, Runhui Fan, Yayun Peng, Ting Cai. (2022) Impact of bile salt on solution-mediated phase transformation of pharmaceutical cocrystals: The importance of coformer release kinetics. CHEMICAL ENGINEERING JOURNAL, 435 (134928). [PMID:] |
26. Li-Juan Lang, Min Wang, Chang Lei, Yi Shen, Qi-Jie Zhu, Hong-Mei Diao, Hao Chen, Lei Shen, Xiang Dong, Bei Jiang, Chao-Jiang Xiao. (2022) Phloridzin Highly Accumulated in Malus rockii Rehder and Its Structure Revision and Hypolipidemic Activity. PLANTA MEDICA, 88 (13): (1190-1198). [PMID:34875697] |
27. Yanbei Tu, Lihua Tan, Tao Lu, Kai Wang, Haiyong Wang, Bing Han, Yuxin Zhao, Hanbin Chen, Yanfang Li, Haixia Chen, Meiwan Chen, Chengwei He. (2022) Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways. BIOCHEMICAL PHARMACOLOGY, 197 (114912). [PMID:35032460] |
28. Feng Huixia, Chen Guilin, Zhang Yongli, Guo Mingquan. (2021) Exploring Multifunctional Bioactive Components from Podophyllum sinense Using Multi-Target Ultrafiltration. Frontiers in Pharmacology, 12 [PMID:34759823] |
29. Yang Shirui, Zhang Wenxiang, Liu Zheyi, Zhai Ziyang, Hou Xudong, Wang Ping, Ge Guangbo, Wang Fangjun. (2021) Lysine reactivity profiling reveals molecular insights into human serum albumin–small-molecule drug interactions. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 413 (30): (7431-7440). [PMID:34676431] |
30. Wang Shihai, Zhou Yu, Tao Wangwang, Liu Jingyi, Chen Hongxiang, Zhao Zuyi. (2022) Fe3O4-modified amphiphilic polyurethane nanoparticles with good stability as magnetic-targeted drug carriers. POLYMER BULLETIN, 79 (10): (8617-8631). [PMID:] |
31. Tao Lijun, Chen Lina, Pei Yanmin, Ma Ping, Xu Qingbin, Wang Jialing, Yu Yang, Cheng Jiang, Zhou Ru. (2021) Vasodilatory effects of betaine on isolated rat pulmonary artery rings. PHARMAZIE, 76 (10): (499-502). [PMID:34620278] |
32. Qing Wang,Mao Ye,Li Xu,Zhi-guo Shi. (2015-09-01) A reversed-phase/hydrophilic interaction mixed-mode C18-Diol stationary phase for multiple applications.. Analytica chimica acta, 888 (182-190). [PMID:26320974] |
33. Chaonan Huang,Yun Li,Jiajia Yang,Junyu Peng,Jun Tan,Yun Fan,Longxing Wang,Jiping Chen. (2018-09-03) Hyperbranched mixed-mode anion-exchange polymeric sorbent for highly selective extraction of nine acidic non-steroidal anti-inflammatory drugs from human urine.. Talanta, 190 (15-22). [PMID:30172492] |
34. Xiaofei Han,Jia Chen,Zhan Li,Kaijun Quan,Hongdeng Qiu. (2020-09-07) Magnetic solid-phase extraction of triazole fungicides based on magnetic porous carbon prepared by combustion combined with solvothermal method.. Analytica chimica acta, 1129 (85-97). [PMID:32891394] |
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25. Jiahui Chen, Minshan Guo, Runhui Fan, Yayun Peng, Ting Cai. (2022) Impact of bile salt on solution-mediated phase transformation of pharmaceutical cocrystals: The importance of coformer release kinetics. CHEMICAL ENGINEERING JOURNAL, 435 (134928). [PMID:] |
26. Li-Juan Lang, Min Wang, Chang Lei, Yi Shen, Qi-Jie Zhu, Hong-Mei Diao, Hao Chen, Lei Shen, Xiang Dong, Bei Jiang, Chao-Jiang Xiao. (2022) Phloridzin Highly Accumulated in Malus rockii Rehder and Its Structure Revision and Hypolipidemic Activity. PLANTA MEDICA, 88 (13): (1190-1198). [PMID:34875697] |
27. Yanbei Tu, Lihua Tan, Tao Lu, Kai Wang, Haiyong Wang, Bing Han, Yuxin Zhao, Hanbin Chen, Yanfang Li, Haixia Chen, Meiwan Chen, Chengwei He. (2022) Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways. BIOCHEMICAL PHARMACOLOGY, 197 (114912). [PMID:35032460] |
28. Feng Huixia, Chen Guilin, Zhang Yongli, Guo Mingquan. (2021) Exploring Multifunctional Bioactive Components from Podophyllum sinense Using Multi-Target Ultrafiltration. Frontiers in Pharmacology, 12 [PMID:34759823] |
29. Yang Shirui, Zhang Wenxiang, Liu Zheyi, Zhai Ziyang, Hou Xudong, Wang Ping, Ge Guangbo, Wang Fangjun. (2021) Lysine reactivity profiling reveals molecular insights into human serum albumin–small-molecule drug interactions. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 413 (30): (7431-7440). [PMID:34676431] |
30. Wang Shihai, Zhou Yu, Tao Wangwang, Liu Jingyi, Chen Hongxiang, Zhao Zuyi. (2022) Fe3O4-modified amphiphilic polyurethane nanoparticles with good stability as magnetic-targeted drug carriers. POLYMER BULLETIN, 79 (10): (8617-8631). [PMID:] |
31. Tao Lijun, Chen Lina, Pei Yanmin, Ma Ping, Xu Qingbin, Wang Jialing, Yu Yang, Cheng Jiang, Zhou Ru. (2021) Vasodilatory effects of betaine on isolated rat pulmonary artery rings. PHARMAZIE, 76 (10): (499-502). [PMID:34620278] |
32. Qing Wang,Mao Ye,Li Xu,Zhi-guo Shi. (2015-09-01) A reversed-phase/hydrophilic interaction mixed-mode C18-Diol stationary phase for multiple applications.. Analytica chimica acta, 888 (182-190). [PMID:26320974] |
33. Chaonan Huang,Yun Li,Jiajia Yang,Junyu Peng,Jun Tan,Yun Fan,Longxing Wang,Jiping Chen. (2018-09-03) Hyperbranched mixed-mode anion-exchange polymeric sorbent for highly selective extraction of nine acidic non-steroidal anti-inflammatory drugs from human urine.. Talanta, 190 (15-22). [PMID:30172492] |
34. Xiaofei Han,Jia Chen,Zhan Li,Kaijun Quan,Hongdeng Qiu. (2020-09-07) Magnetic solid-phase extraction of triazole fungicides based on magnetic porous carbon prepared by combustion combined with solvothermal method.. Analytica chimica acta, 1129 (85-97). [PMID:32891394] |