Indotecan - 98%, high purity , CAS No.915303-09-2

  • ≥98%
Item Number
I412147
Grouped product items
SKUSizeAvailabilityPrice Qty
I412147-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$39.90
I412147-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$121.90
I412147-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$210.90
I412147-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$376.90
I412147-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$627.90

Basic Description

SynonymsCS-0007476 | Indotecan(LMP400) | LMP400 | LMP-400 | LMP400; LMP-400; LMP 400 | HY-18351 | 3-[(Morpholine)-1-propyl]-5,3-dimethoxy-8,9-meth ylenedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline | AKOS040741879 | NSC-724998LMP-400 | UNII-BTA69L5M8D | BTA69L5M
Specifications & Purity≥98%
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
Product Description

Information

Indotecan (LMP-400, NSC-724998) is a potent topoisomerase 1(Top1) inhibitor with IC50 of 300 nM, 1200 nM, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.

Associated Targets(Human)

TOP1 Tclin DNA topoisomerase I (7553 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-145 (51482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-3 (48710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SN12C (47755 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UACC-62 (47335 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HOP-62 (47048 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-435 (38290 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SF-539 (44845 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Leishmania infantum (5912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 15,16-dimethoxy-20-(3-morpholin-4-ylpropyl)-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione
INCHI InChI=1S/C26H26N2O7/c1-31-19-10-15-18(13-20(19)32-2)26(30)28(5-3-4-27-6-8-33-9-7-27)24-16-11-21-22(35-14-34-21)12-17(16)25(29)23(15)24/h10-13H,3-9,14H2,1-2H3
InChi Key FMFIFGLHVOZDEL-UHFFFAOYSA-N
Canonical SMILES COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)CCCN6CCOCC6)OC
Isomeric SMILES COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)CCCN6CCOCC6)OC
PubChem CID 11533060
Molecular Weight 478.49

Certificates

Certificate of Analysis(COA)

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10 results found

Lot NumberCertificate TypeDateItem
I2404535Certificate of AnalysisJun 04, 2024 I412147
I2404536Certificate of AnalysisJun 04, 2024 I412147
I2404537Certificate of AnalysisJun 04, 2024 I412147
I2404538Certificate of AnalysisJun 04, 2024 I412147
I2404539Certificate of AnalysisJun 04, 2024 I412147
I2404540Certificate of AnalysisJun 04, 2024 I412147
I2404541Certificate of AnalysisJun 04, 2024 I412147
I2404564Certificate of AnalysisJun 04, 2024 I412147
I2404565Certificate of AnalysisJun 04, 2024 I412147
I2404566Certificate of AnalysisJun 04, 2024 I412147

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