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INF 39 - 10mM in DMSO, high purity , CAS No.866028-26-4
Irreversible NLRP3 inhibitor
Basic Description Synonyms Ethyl 2-(2-chlorobenzyl)acrylate Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Irreversible NLRP3 inhibitor (exhibits 52% inhibition of NLRP3 ATPase at 100 μM). Inhibits IL-1β release, caspase activation and pyroptosis in THP-1 cells. Reduces inflammation in a rat colitis model. Exhibits low cytotoxicity. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name ethyl 2-[(2-chlorophenyl)methyl]prop-2-enoate INCHI InChI=1S/C12H13ClO2/c1-3-15-12(14)9(2)8-10-6-4-5-7-11(10)13/h4-7H,2-3,8H2,1H3 InChi Key VTAOWWAFBSFWSG-UHFFFAOYSA-N Canonical SMILES CCOC(=O)C(=C)CC1=CC=CC=C1Cl Isomeric SMILES CCOC(=O)C(=C)CC1=CC=CC=C1Cl PubChem CID 69150705 Molecular Weight 224.68
Safety and Hazards(GHS) RIDADR NONHforallmodesoftransport
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