inhibitor 19 , CAS No.I611069, Inhibitor of Leucyl-cysteinyl aminopeptidase

Item Number
I611069
Grouped product items
SKUSizeAvailabilityPrice Qty
I611069-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$900.90
I611069-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of Leucyl-cysteinyl aminopeptidase

Associated Targets(Human)

ANPEP Tchem Aminopeptidase N (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
LNPEP Tchem Leucyl-cystinyl aminopeptidase (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ANPEP Tchem Aminopeptidase N (863 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LNPEP Tchem Cystinyl aminopeptidase (313 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Il1rn Interleukin-1 receptor antagonist protein (23 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 2-[2-[[[(2S,6S,9E,13S)-13-amino-2-[(4-hydroxyphenyl)methyl]-4,14-dioxo-1,5-diazacyclotetradec-9-ene-6-carbonyl]amino]methyl]phenyl]acetic acid
INCHI InChI=1S/C29H36N4O6/c30-24-9-3-1-2-4-10-25(29(39)31-18-21-8-6-5-7-20(21)16-27(36)37)33-26(35)17-22(32-28(24)38)15-19-11-13-23(34)14-12-19/h1-2,5-8,11-14,22,24-25,34H,3-4,9-10,15-18,30H2,(H,31,39)(H,32,38)(H,33,35)(H,36,37)/b2-1+/t22-,24-,25-/m0/s1
InChi Key QUJXIMWUJGTUEG-CLKUPZDLSA-N
Canonical SMILES O=C1C[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CC/C=C/CC[C@H](N1)C(=O)NCc1ccccc1CC(=O)O
Isomeric SMILES C\1C[C@@H](C(=O)N[C@H](CC(=O)N[C@@H](CC/C=C1)C(=O)NCC2=CC=CC=C2CC(=O)O)CC3=CC=C(C=C3)O)N
PubChem CID 53259050

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Chai SY, Bastias MA, Clune EF, Matsacos DJ, Mustafa T, Lee JH, McDowall SG, Paxinos G, Mendelsohn FA, Albiston AL.  (2000)  Distribution of angiotensin IV binding sites (AT4 receptor) in the human forebrain, midbrain and pons as visualised by in vitro receptor autoradiography..  J Chem Neuroanat,  20  (3-4): (339-48).  [PMID:11207430]
2. Chai SY, Yeatman HR, Parker MW, Ascher DB, Thompson PE, Mulvey HT, Albiston AL.  (2008)  Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase..  BMC Neurosci,  9 Suppl 2  (3): (S14).  [PMID:19090987]
3. Wright JW, Harding JW.  (2008)  The angiotensin AT4 receptor subtype as a target for the treatment of memory dysfunction associated with Alzheimer's disease..  J Renin Angiotensin Aldosterone Syst,  (4): (226-37).  [PMID:19126664]
4. Andersson H, Demaegdt H, Johnsson A, Vauquelin G, Lindeberg G, Hallberg M, Erdelyi M, Karlen A, Hallberg A.  (2011)  Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis..  J Med Chem,  54  (11): (3779-92).  [PMID:21476495]

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