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INK 128 (MLN0128) - ≥98%, high purity , Serine/threonine-protein kinase mTOR inhibitor, CAS No.1224844-38-5, Serine/threonine-protein kinase mTOR inhibitor

Moligand™
≥98%

CAS#: 1224844-38-5
Formula: C₁₅H₁₅N₇O
Molecular Weight: 309.33
PubChem CID: 45375953

Item Number

I128086

Grouped product items
SKU	Size	Availability	Price
I128086-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$94.90
I128086-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$427.90
I128086-100mg	100mg	In stock	$533.90

View related series

mechanistic target of rapamycin kinase Inhibitor phosphatidylinositol-4，5-bisphosphate 3-kinase catalytic subunit alpha Inhibitor phosphatidylinositol-4，5-bisphosphate 3-kinase catalytic subunit delta Inhibitor phosphatidylinositol-4，5-bisphosphate 3-kinase catalytic subunit gamma Inhibitor

Basic Description

Synonyms	Sapanisertib\|1224844-38-5\|INK-128\|MLN0128\|INK 128\|INK128\|TAK-228\|MLN-0128\|5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine\|INK 128 (MLN0128)\|Sapanisertib (MLN0128)\|UNII-JGH0DF1U03\|JGH0DF1U03\|CB-228\|3-(2-Amino-5-benzoxazolyl)-
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	INK 128 exhibits an enzymatic inhibition activity against mTOR and more than 100-fold selectivity to PI3K kinases [1]. As TORC1/2 inhibitor, INK 128 inhibits both the phosphorylation of S6 and 4EBP1, the downstream substrates of TORC1, and selectively inh
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Serine/threonine-protein kinase mTOR inhibitor
Note	5mg卖完停产，不再备货
Product Description	INK 128 (MLN0128) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin). A potent and selective TORC1/2 inhibitor

Associated Targets

RPTOR Tbio Regulatory-associated protein of mTOR 0 Activities

Discover Target: RPTOR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPKAP1 Tbio Target of rapamycin complex 2 subunit MAPKAP1 0 Activities

Discover Target: MAPKAP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIK3CG Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1 Activities

Discover Target: PIK3CG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIK3CA Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1 Activities

Discover Target: PIK3CA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIK3CB Tchem Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 0 Activities

Discover Target: PIK3CB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIK3CD Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1 Activities

Discover Target: PIK3CD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PI4KB Tchem Phosphatidylinositol 4-kinase beta 0 Activities

Discover Target: PI4KB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIK3C3 Tchem Phosphatidylinositol 3-kinase catalytic subunit type 3 0 Activities

Discover Target: PIK3C3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RPS6KB1 Tchem Ribosomal protein S6 kinase beta-1 0 Activities

Discover Target: RPS6KB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MTOR Tclin Serine/threonine-protein kinase mTOR 2 Activities

Discover Target: MTOR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine
INCHI	InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19)
InChi Key	GYLDXIAOMVERTK-UHFFFAOYSA-N
Canonical SMILES	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC(=N4)N)N
Isomeric SMILES	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC(=N4)N)N
PubChem CID	45375953
Molecular Weight	309.33

PubChem CID

45375953

CAS Registry No.

1224844-38-5

RCSB PDB Ligand

FE5

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
B2225533	Certificate of Analysis	Dec 14, 2023	I128086
E1705099	Certificate of Analysis	Dec 08, 2022	I128086

References

1. Liu Q, Thoreen C, Wang J, Sabatini D, Gray NS. (2009) mTOR Mediated Anti-Cancer Drug Discovery.. Drug Discov Today Ther Strateg, 6 (2): (47-55). [PMID:20622997]
2. Schenone S, Brullo C, Musumeci F, Radi M, Botta M. (2011) ATP-competitive inhibitors of mTOR: an update.. Curr Med Chem, 18 (20): (2995-3014). [PMID:21651476]
3. Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ et al.. (2012) The translational landscape of mTOR signalling steers cancer initiation and metastasis.. Nature, 485 (7396): (55-61). [PMID:22367541]
4. Arendse LB, Murithi JM, Qahash T, Pasaje CFA, Godoy LC, Dey S, Gibhard L, Ghidelli-Disse S, Drewes G, Bantscheff M et al.. (2022) The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages.. Sci Transl Med, 14 (667): (eabo7219). [PMID:36260689]

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