1.Rizzo G, Passeri D, De Franco F, Ciaccioli G, Donadio L, Rizzo G, Orlandi S, Sadeghpour B, Wang XX, Jiang T et al.. (2010) Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist.. Mol Pharmacol, 78 (4):(617-30). [PMID:20631053][10.1021/op500134e]
2.Wang XX, Luo Y, Wang D, Adorini L, Pruzanski M, Dobrinskikh E, Levi M. (2017) A dual agonist of farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice.. J Biol Chem, 292 (29):(12018-12024). [PMID:28596381][10.1021/op500134e]
3.Wang XX, Wang D, Luo Y, Myakala K, Dobrinskikh E, Rosenberg AZ, Levi J, Kopp JB, Field A, Hill A et al.. (2018) FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity.. J Am Soc Nephrol, 29 (1):(118-137). [PMID:29089371][10.1021/op500134e]
4.Comeglio P, Cellai I, Mello T, Filippi S, Maneschi E, Corcetto F, Corno C, Sarchielli E, Morelli A, Rapizzi E et al.. (2018) INT-767 prevents NASH and promotes visceral fat brown adipogenesis and mitochondrial function.. J Endocrinol, 238 (2):(107-127). [PMID:29945982][10.1021/op500134e]
5.Hu YB, Liu XY, Zhan W. (2018) Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis.. Drug Des Devel Ther, 12 (13):(2213-2221). [PMID:30038487][10.1021/op500134e]
6.Iracheta-Vellve A, Calenda CD, Petrasek J, Ambade A, Kodys K, Adorini L, Szabo G. (2018) FXR and TGR5 Agonists Ameliorate Liver Injury, Steatosis, and Inflammation After Binge or Prolonged Alcohol Feeding in Mice.. Hepatol Commun, 2 (11):(1379-1391). [PMID:30411084][10.1021/op500134e]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.