Iodoacetamide - Ultra pure,≥99% (NMR), high purity , CAS No.144-48-9

Item Number
I131590
Grouped product items
SKUSizeAvailabilityPrice Qty
I131590-5g
5g
In stock
$38.90
I131590-25g
25g
In stock
$175.90
I131590-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$632.90

Alkylating agent.

Basic Description

SynonymsA808220 | Iodoacetamide, >=98.0% (AT), purum | Iodoacetamide, Single use vial of 56 mg | SCHEMBL20371 | 1219802-64-8 | PGLTVOMIXTUURA-UHFFFAOYSA- | WLN: ZV1I | BDBM50376514 | GTPL6271 | IODOACETAMIDE-D4 | NCGC00015548-06 | NCGC00093954-01 | alpha-Iodoacet
Specifications & PurityMoligand™, SuperPure grade, ≥99%(NMR)
Biochemical and Physiological MechanismsAlkylating agent used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation.
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™, SuperPure grade
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Alkylating reagent for cysteine residues in peptide sequencing.

Associated Targets(Human)

CYP3A4 Tclin Cytochrome P450 3A4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TYMS Tclin Thymidylate synthase (1651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AK2 Tbio Adenylate kinase 2 (264 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLA Tclin Alpha-galactosidase A (5444 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
F13A1 Tchem Coagulation factor XIII (223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP2 Tbio Ubiquitin carboxyl-terminal hydrolase 2 (8818 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THPO Tbio Thrombopoietin (834 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATG4B Tchem Cysteine protease ATG4B (985 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADH1A Tclin Alcohol dehydrogenase (35 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
crtY Lycopene cyclase (9 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-iodoacetamide
INCHI InChI=1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)
InChi Key PGLTVOMIXTUURA-UHFFFAOYSA-N
Canonical SMILES C(C(=O)N)I
Isomeric SMILES C(C(=O)N)I
WGK Germany 3
RTECS AC4200000
PubChem CID 3727
UN Number 2811
Packing Group III
Molecular Weight 184.96
Beilstein 1739080
Reaxy-Rn 1739080

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

27 results found

Lot NumberCertificate TypeDateItem
L2205007Certificate of AnalysisSep 06, 2024 I131590
H2407608Certificate of AnalysisMay 21, 2024 I131590
H2407605Certificate of AnalysisMay 21, 2024 I131590
H2407604Certificate of AnalysisMay 21, 2024 I131590
E2406092Certificate of AnalysisApr 23, 2024 I131590
E2406119Certificate of AnalysisApr 23, 2024 I131590
E2406136Certificate of AnalysisApr 23, 2024 I131590
J2309571Certificate of AnalysisSep 07, 2023 I131590
J2309543Certificate of AnalysisSep 07, 2023 I131590
H2311034Certificate of AnalysisNov 25, 2022 I131590
L2203418Certificate of AnalysisNov 25, 2022 I131590
H2325040Certificate of AnalysisNov 25, 2022 I131590
B2307276Certificate of AnalysisNov 25, 2022 I131590
L2002051Certificate of AnalysisSep 19, 2022 I131590
K2027099Certificate of AnalysisSep 16, 2022 I131590
J2022289Certificate of AnalysisAug 09, 2022 I131590
G2209310Certificate of AnalysisJun 23, 2022 I131590
G2209309Certificate of AnalysisJun 23, 2022 I131590
F2213199Certificate of AnalysisJun 15, 2022 I131590
F2222392Certificate of AnalysisMay 31, 2022 I131590
F2222383Certificate of AnalysisMay 31, 2022 I131590
G2006045Certificate of AnalysisApr 27, 2022 I131590
C2017167Certificate of AnalysisJan 19, 2022 I131590
A2221086Certificate of AnalysisJan 13, 2022 I131590
J2231082Certificate of AnalysisJan 13, 2022 I131590
J2231085Certificate of AnalysisJan 13, 2022 I131590
A2221087Certificate of AnalysisJan 13, 2022 I131590

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Chemical and Physical Properties

SensitivityLight & Moisture Sensitive
Melt Point(°C)95°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08,   GHS07
Signal Danger
Hazard Statements

H301:Toxic if swallowed

H413:May cause long lasting harmful effects to aquatic life

H317:May cause an allergic skin reaction

H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P284:[In case of inadequate ventilation] Wear respiratory protection.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

WGK Germany 3
RTECS AC4200000
Reaxy-Rn 1739080
Class 6.1

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41. Xin-Xin Li, Li-Shun Zhang, Chao Wang, Yan-Ping Huang, Zhao-Sheng Liu.  (2018)  Green synthesis of monolithic column incorporated with graphene oxide using room temperature ionic liquid and eutectic solvents for capillary electrochromatography.  TALANTA,  178  (763).  [PMID:29136892] [10.1016/j.talanta.2017.10.014]
42. Dai Lili, Jin Shanxia, Fan Mengying, Zhou Ping.  (2017)  Preparation of quaternized cellulose/chitosan microspheres for selective enrichment of phosphopeptides.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  409  (13): (3309-3317).  [PMID:28258465] [10.1007/s00216-017-0273-2]
43. Yang Xiaoqing, Xia Yan.  (2016)  Urea-modified metal-organic framework of type MIL-101(Cr) for the preconcentration of phosphorylated peptides.  MICROCHIMICA ACTA,  183  (7): (2235-2240).  [PMID:] [10.1007/s00604-016-1860-1]
44. Guihua Ruan, Zhenwei Wu, Yipeng Huang, Meiping Wei, Rihui Su, Fuyou Du.  (2016)  An easily regenerable enzyme reactor prepared from polymerized high internal phase emulsions.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,  473  (54).  [PMID:26995089] [10.1016/j.bbrc.2016.03.049]
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46. Nannan Chen, Lianzhu Lin, Weizheng Sun, Mouming Zhao.  (2014)  Stable and pH-Sensitive Protein Nanogels Made by Self-Assembly of Heat Denatured Soy Protein.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  62  (39): (9553–9561).  [PMID:25180907] [10.1021/jf502572d]
47. Zhengyi Chen, Yongle Li, Shuhai Lin, Meiping Wei, Fuyou Du, Guihua Ruan.  (2014)  Development of continuous microwave-assisted protein digestion with immobilized enzyme.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,  445  (491).  [PMID:24530398] [10.1016/j.bbrc.2014.02.025]
48. Long Ji, Yonglei Yuan, Liping Luo, Zhe Chen, Xiaoqiong Ma, Zhongjun Ma, Lin Cheng.  (2012)  Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors.  STEROIDS,  77  (441).  [PMID:22197662] [10.1016/j.steroids.2011.11.016]
49. Yonglei Yuan,Long Ji,Liping Luo,Juan Lu,Xiaoqiong Ma,Zhongjun Ma,Zhe Chen.  (2012-09-11)  Quinone reductase (QR) inducers from Andrographis paniculata and identification of molecular target of andrographolide..  Fitoterapia,  83  ((8)): (1506-1513).  [PMID:22960348]

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46. Nannan Chen, Lianzhu Lin, Weizheng Sun, Mouming Zhao.  (2014)  Stable and pH-Sensitive Protein Nanogels Made by Self-Assembly of Heat Denatured Soy Protein.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  62  (39): (9553–9561).  [PMID:25180907] [10.1021/jf502572d]
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Solution Calculators