Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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I131590-5g | 5g | In stock | $38.90 | |
I131590-25g | 25g | In stock | $175.90 | |
I131590-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $632.90 |
Alkylating agent.
Synonyms | A808220 | Iodoacetamide, >=98.0% (AT), purum | Iodoacetamide, Single use vial of 56 mg | SCHEMBL20371 | 1219802-64-8 | PGLTVOMIXTUURA-UHFFFAOYSA- | WLN: ZV1I | BDBM50376514 | GTPL6271 | IODOACETAMIDE-D4 | NCGC00015548-06 | NCGC00093954-01 | alpha-Iodoacet |
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Specifications & Purity | Moligand™, SuperPure grade, ≥99%(NMR) |
Biochemical and Physiological Mechanisms | Alkylating agent used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™, SuperPure grade |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Alkylating reagent for cysteine residues in peptide sequencing. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-iodoacetamide |
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INCHI | InChI=1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5) |
InChi Key | PGLTVOMIXTUURA-UHFFFAOYSA-N |
Canonical SMILES | C(C(=O)N)I |
Isomeric SMILES | C(C(=O)N)I |
WGK Germany | 3 |
RTECS | AC4200000 |
PubChem CID | 3727 |
UN Number | 2811 |
Packing Group | III |
Molecular Weight | 184.96 |
Beilstein | 1739080 |
Reaxy-Rn | 1739080 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
L2205007 | Certificate of Analysis | Sep 06, 2024 | I131590 |
H2407608 | Certificate of Analysis | May 21, 2024 | I131590 |
H2407605 | Certificate of Analysis | May 21, 2024 | I131590 |
H2407604 | Certificate of Analysis | May 21, 2024 | I131590 |
E2406092 | Certificate of Analysis | Apr 23, 2024 | I131590 |
E2406119 | Certificate of Analysis | Apr 23, 2024 | I131590 |
E2406136 | Certificate of Analysis | Apr 23, 2024 | I131590 |
J2309571 | Certificate of Analysis | Sep 07, 2023 | I131590 |
J2309543 | Certificate of Analysis | Sep 07, 2023 | I131590 |
H2311034 | Certificate of Analysis | Nov 25, 2022 | I131590 |
L2203418 | Certificate of Analysis | Nov 25, 2022 | I131590 |
H2325040 | Certificate of Analysis | Nov 25, 2022 | I131590 |
B2307276 | Certificate of Analysis | Nov 25, 2022 | I131590 |
L2002051 | Certificate of Analysis | Sep 19, 2022 | I131590 |
K2027099 | Certificate of Analysis | Sep 16, 2022 | I131590 |
J2022289 | Certificate of Analysis | Aug 09, 2022 | I131590 |
G2209310 | Certificate of Analysis | Jun 23, 2022 | I131590 |
G2209309 | Certificate of Analysis | Jun 23, 2022 | I131590 |
F2213199 | Certificate of Analysis | Jun 15, 2022 | I131590 |
F2222392 | Certificate of Analysis | May 31, 2022 | I131590 |
F2222383 | Certificate of Analysis | May 31, 2022 | I131590 |
G2006045 | Certificate of Analysis | Apr 27, 2022 | I131590 |
C2017167 | Certificate of Analysis | Jan 19, 2022 | I131590 |
A2221086 | Certificate of Analysis | Jan 13, 2022 | I131590 |
J2231082 | Certificate of Analysis | Jan 13, 2022 | I131590 |
J2231085 | Certificate of Analysis | Jan 13, 2022 | I131590 |
A2221087 | Certificate of Analysis | Jan 13, 2022 | I131590 |
Sensitivity | Light & Moisture Sensitive |
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Melt Point(°C) | 95°C |
Pictogram(s) | GHS06, GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H413:May cause long lasting harmful effects to aquatic life H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately. |
WGK Germany | 3 |
RTECS | AC4200000 |
Reaxy-Rn | 1739080 |
Class | 6.1 |
1. Xu Daokun, Huang Haolun, Liu Zhen, Wang Yumei, Liu Qinan, Jiang Xing, Yang Jun, Ling Rui. (2023) Comprehensive characterization and detection of nut allergens in bakery foods using Q–TOF mass spectrometry and bioinformatics. Food Quality and Safety, (1): [PMID:11741838] [10.1093/fqsafe/fyad061] |
2. Zheng Zhang, Qiyao Xu, Mengxing Gou, Chang Zhu, Wanchun Guo, Ruifeng Hu, Liyan Wang, Xuejun Liu. (2024) Potential mechanism of improved cryotolerance of Pediococcus pentosaceus YT2 by cold acclimation based on TMT quantitative proteomics analysis. LWT-FOOD SCIENCE AND TECHNOLOGY, 192 (115714). [PMID:] [10.1016/j.lwt.2023.115714] |
3. Juan Xue, Jun Lv, Lanfang Liu, Fangfang Duan, Aiying Shi, Xuemeng Ji, Li Ding. (2024) Maltodextrin-binding protein as a key factor in Cronobacter sakazakii survival under desiccation stress. FOOD RESEARCH INTERNATIONAL, 177 (113871). [PMID:38225116] [10.1016/j.foodres.2023.113871] |
4. Qingqing Cao, Haiyan Zhu, Wei Xu, Rongrong Zhang, Yun Wang, Zhaofang Tian, Yufang Yuan. (2023) Predicting the efficacy of glucocorticoids in pediatric primary immune thrombocytopenia using plasma proteomics. Frontiers in Immunology, 14 (1301227). [PMID:38162645] [10.3389/fimmu.2023.1301227] |
5. Xiaoyu Yuan, Jiayi Song, Han Wang, Wenkang Zhang, Ying Liu, Ping Su, Yi Yang. (2024) Dual-functionalized two-dimensional metal–organic framework composite with highly hydrophilicity for effective enrichment of glycopeptides. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1232 (123920). [PMID:38101285] [10.1016/j.jchromb.2023.123920] |
6. Ping Lu, Juan Xue, Xi Chen, Xuemeng Ji. (2023) Impact of DnaK on protein expression and deamidation modification in Cronobacter sakazakii: insights from proteomic analysis. Microbiology Resource Announcements, 12 (10): [PMID:37747248] [10.1128/MRA.00516-23] |
7. Ping Lu, Mengyuan Shan, Xuemeng Ji, Fuqi Deng, Yan Wang. (2023) EPURISp: Combining Enzymatic Digestion, Ultrafiltration, and Rapid In Situ Sample Purification for High-performance Proteomics. JOURNAL OF PROTEOME RESEARCH, 22 (10): (3392–3400). [PMID:37747260] [10.1021/acs.jproteome.3c00505] |
8. Wang Bing, Zhang Xiaoya, Wang Baichun, Feng Quanshou, Luo Yiting, Wang Weimin, Ding Chuan-Fan, Yan Yinghua. (2023) Ti4+ functionalized β-cyclodextrin covalent organic framework as a new immobilized metal ion affinity chromatography platform for selective capture of phosphorylated peptides and exosomes. MICROCHIMICA ACTA, 190 (10): (1-8). [PMID:37723224] [10.1007/s00604-023-05952-3] |
9. Yangwei Xiang, Huan Xu. (2023) Occurrence, formation, and proteins perturbation of disinfection byproducts in indoor air resulting from chlorine disinfection. CHEMOSPHERE, 343 (29): (140182). [PMID:37716567] [10.1016/j.chemosphere.2023.140182] |
10. Mingming Xu, Hong Jin, Wei Ge, Lingbo Zhao, Zhaoliang Liu, Zeyu Guo, Zhen Wu, Jing Chen, Chengjie Mao, Xumin Zhang, Chun-Feng Liu, Shuang Yang. (2023) Mass Spectrometric Analysis of Urinary N-Glycosylation Changes in Patients with Parkinson’s Disease. ACS Chemical Neuroscience, [PMID:37677068] [10.1021/acschemneuro.3c00404] |
11. Jue Wang, Sai Gu, Bo Qin. (2023) Eosinophil and mast cell-derived exosomes promote integrity of intestinal mucosa via the NEAT1/miR-211-5p/glial cell line-derived neurotrophic factor axis in duodenum. ENVIRONMENTAL TOXICOLOGY, 38 (11): (2595-2607). [PMID:37466184] [10.1002/tox.23895] |
12. Ping Lu, Xiaoli Dong, Xuemeng Ji. (2023) Cronobacter sakazakii Pyridoxal Kinase PdxY Mediated by TreR and pESA3 Is Essential for Vitamin B6 (PLP) Maintenance and Virulence. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 89 (8): [PMID:37458600] [10.1128/aem.00924-23] |
13. Ping Lu, Juan Xue, Xi Chen, Xuemeng Ji. (2023) DnaK-Mediated Protein Deamidation: a Potential Mechanism for Virulence and Stress Adaptation in Cronobacter sakazakii. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 89 (7): [PMID:37382536] [10.1128/aem.00505-23] |
14. Erdong Yuan, Miao Zhou, Zhengyang Liang, William Kwame Amakye, Chuanli Hou, Jiaoyan Ren. (2023) Effect of sturgeon protein in promoting the adhesion of Lactobacillus plantarum and Lactobacillus rhamnosus. Food Bioscience, 54 (102863). [PMID:] [10.1016/j.fbio.2023.102863] |
15. Ziyuan Gao, Sufeng Chen, Jing Du, Zhen Wu, Wei Ge, Song Gao, Zeyang Zhou, Xiaodong Yang, Yufei Xing, Minhua Shi, Yunyun Hu, Wen Tang, Jun Xia, Xumin Zhang, Junhong Jiang, Shuang Yang. (2023) Quantitative analysis of fucosylated glycoproteins by immobilized lectin-affinity fluorescent labeling. RSC Advances, 13 (10): (6676-6687). [PMID:36860533] [10.1039/D3RA00072A] |
16. Tian Su, Zhengyi Zhang, Xiao Han, Fei Yang, Zhen Wang, Ying Cheng, Huadong Liu. (2022) Systematic Insight of Resveratrol Activated SIRT1 Interactome through Proximity Labeling Strategy. Antioxidants, 11 (12): (2330). [PMID:36552538] [10.3390/antiox11122330] |
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19. Mingming Xu, Hong Jin, Zhen Wu, Ying Han, Jing Chen, Chengjie Mao, Piliang Hao, Xumin Zhang, Chun-Feng Liu, Shuang Yang. (2022) Mass Spectrometry-Based Analysis of Serum N-Glycosylation Changes in Patients with Parkinson’s Disease. ACS Chemical Neuroscience, 13 (12): (1719–1726). [PMID:35640092] [10.1021/acschemneuro.2c00264] |
20. He Qi, Gang Chen, Qiong Jia. (2022) Metal-organic framework-mediated synthesis of hierarchical layered double hydroxide for high-efficiency enrichment of phosphopeptides. TALANTA, 247 (123563). [PMID:35617795] [10.1016/j.talanta.2022.123563] |
21. Jialing Huang, Yunqing Qi, Xiaowen Zeng, Wei Huang, Da Chen. (2022) Simultaneous quantification of plasma immunoglobulin subclasses for assessment of maternal and fetal immune response during pregnancy. JOURNAL OF CHROMATOGRAPHY A, 1673 (463096). [PMID:35526301] [10.1016/j.chroma.2022.463096] |
22. Tian Su, Zhen Wang, Zhengyi Zhang, Zhanwu Hou, Xiao Han, Fei Yang, Huadong Liu. (2022) Resveratrol regulates Hsp60 in HEK 293T cells during activation of SIRT1 revealed by nascent protein labeling strategy. Food & Nutrition Research, 66 ( 10.29219/fnr.v66.8224). [PMID:35517847] [10.29219/fnr.v66.8224] |
23. Jiamei Xu, Yu Liu, Jingjing Ma, Pengpeng Li, Zhiming Geng, Daoying Wang, Muhan Zhang, Weimin Xu. (2022) Recombinant Porcine 12-Lipoxygenase Catalytic Domain: Effect of Inhibitors, Selectivity of Substrates and Specificity of Oxidation Products of Linoleic Acid. Foods, 11 (7): (980). [PMID:35407067] [10.3390/foods11070980] |
24. Zehu Xie, Quanshou Feng, Xiang Fang, Xinhua Dai, Yinghua Yan, Chuan-Fan Ding. (2022) One-Pot Preparation of Hydrophilic Glucose Functionalized Quantum Dots for Diabetic Serum Glycopeptidome Analysis. MICROCHEMICAL JOURNAL, 178 (107397). [PMID:] [10.1016/j.microc.2022.107397] |
25. Xue Yu, Zhang Xiao-Guang, Lu Ze-Ping, Xu Chao, Xu Hua-Jin, Hu Yi. (2022) Enhancing the Catalytic Performance of Candida antarctica Lipase B by Chemical Modification With Alkylated Betaine Ionic Liquids. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35265607] [10.3389/fbioe.2022.850890] |
26. Jiangfeng Li, Chongyuan Fan, Yating Yao, Zhaochen Liu, Fangfang Li, Binghua Jiang. (2022) Highly efficient enrichment of intact phosphoproteins by a cadmium ion-based co-precipitation strategy. JOURNAL OF SEPARATION SCIENCE, 45 (7): (1336-1344). [PMID:35108751] [10.1002/jssc.202100892] |
27. Yizhou Gao, Xiaohui Xiong, Hui Wang, Jiajing Wang, Yan Bi, Yuqing Yan, Zhongye Cao, Dayong Li, Fengming Song. (2021) Ero1-Pdi1 module-catalysed dimerization of a nucleotide sugar transporter, FonNst2, regulates virulence of Fusarium oxysporum on watermelon. ENVIRONMENTAL MICROBIOLOGY, 24 (3): (1200-1220). [PMID:34587346] [10.1111/1462-2920.15789] |
28. Zehu Xie, Yinghua Yan, Keqi Tang, Chuan-Fan Ding. (2022) Post-synthesis modification of covalent organic frameworks for ultrahigh enrichment of low-abundance glycopeptides from human saliva and serum. TALANTA, 236 (122831). [PMID:34635221] [10.1016/j.talanta.2021.122831] |
29. Muhammad Mujahid Ali, Zhiyuan Zhu, Dilshad Hussain, Zhengchao Shen, Yutian He, Zhenxia Du. (2021) Flexible and hierarchical metal-organic framework composite as solid-phase media for facile affinity-tip fabrication to selectively enrich glycopeptides and phosphopeptides. TALANTA, 233 (122576). [PMID:34215068] [10.1016/j.talanta.2021.122576] |
30. Hui-min Lin, Xue-er Qi, Shan-shan Shui, Soottawat Benjakul, Santiago P. Aubourg, Bin Zhang. (2021) Label-free proteomic analysis revealed the mechanisms of protein oxidation induced by hydroxyl radicals in whiteleg shrimp (Litopenaeus vannamei) muscle. Food & Function, 12 (10): (4337-4348). [PMID:33881120] [10.1039/D1FO00380A] |
31. He Qi, Zheng Li, Haijiao Zheng, Qiong Jia. (2021) Carnosine functionalized magnetic metal–organic framework nanocomposites for synergistic enrichment of phosphopeptides. ANALYTICA CHIMICA ACTA, 1157 (338383). [PMID:33832591] [10.1016/j.aca.2021.338383] |
32. Chao Xu, Hongbo Suo, Yu Xue, Jing Qin, Hongyue Chen, Yi Hu. (2021) Experimental and theoretical evidence of enhanced catalytic performance of lipase B from Candida antarctica acquired by the chemical modification with amino acid ionic liquids. Molecular Catalysis, 501 (111355). [PMID:] [10.1016/j.mcat.2020.111355] |
33. Xuan Zou, Yang Wang, Yuheng Wang, Junting Yang, Huishu Guo, Zhengxu Cai. (2020) Paeoniflorin Alleviates Abnormalities in Rats with Functional Dyspepsia by Stimulating the Release of Acetylcholine. Drug Design Development and Therapy, 14 ( 5623–5632). [PMID:33376306] [10.2147/DDDT.S260703] |
34. Muhammad Mujahid Ali, Zhiyuan Zhu, Mengyu Wang, Dilshad Hussain, Xia Gao, Jianfeng Wang, Zhenxia Du. (2021) Melamine foam assisted in-tip packed amine-functionalized titanium metal–organic framework for the selective enrichment of endogenous glycopeptides. JOURNAL OF CHROMATOGRAPHY A, 1636 (461711). [PMID:33316563] [10.1016/j.chroma.2020.461711] |
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36. Lili Dai, Zhe Sun, Ping Zhou. (2020) Modification of Luffa Sponge for Enrichment of Phosphopeptides. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (1): (101). [PMID:31877829] [10.3390/ijms21010101] |
37. Xue Zhao, Pei-Ru Fan, Chun-E Mo, Yan-Ping Huang, Zhao-Sheng Liu. (2020) Green synthesis of monolithic enzyme microreactor based on thiol-ene click reaction for enzymatic hydrolysis of protein. JOURNAL OF CHROMATOGRAPHY A, 1611 (460618). [PMID:31672267] [10.1016/j.chroma.2019.460618] |
38. Weigui Luo, Yuan Xiao, Qiwen Liang, Yi Su, Langtao Xiao. (2019) Identification of Potential Auxin-Responsive Small Signaling Peptides through a Peptidomics Approach in Arabidopsis thaliana. MOLECULES, 24 (17): (3146). [PMID:31470600] [10.3390/molecules24173146] |
39. Zhong Banghua, Wang Kewei, Xu Hao, Kong Fanmin. (2018) Silencing Formin-like 2 inhibits growth and metastasis of gastric cancer cells through suppressing internalization of integrins. Cancer Cell International, 18 (1): (1-10). [PMID:29881327] [10.1186/s12935-018-0576-1] |
40. Jing He, Guanghong Zhou, Yun Bai, Chao Wang, Shuran Zhu, Xinglian Xu, Chunbao Li. (2018) The effect of meat processing methods on changes in disulfide bonding and alteration of protein structures: impact on protein digestion products. RSC Advances, 8 (31): (17595-17605). [PMID:35539241] [10.1039/C8RA02310G] |
41. Xin-Xin Li, Li-Shun Zhang, Chao Wang, Yan-Ping Huang, Zhao-Sheng Liu. (2018) Green synthesis of monolithic column incorporated with graphene oxide using room temperature ionic liquid and eutectic solvents for capillary electrochromatography. TALANTA, 178 (763). [PMID:29136892] [10.1016/j.talanta.2017.10.014] |
42. Dai Lili, Jin Shanxia, Fan Mengying, Zhou Ping. (2017) Preparation of quaternized cellulose/chitosan microspheres for selective enrichment of phosphopeptides. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 409 (13): (3309-3317). [PMID:28258465] [10.1007/s00216-017-0273-2] |
43. Yang Xiaoqing, Xia Yan. (2016) Urea-modified metal-organic framework of type MIL-101(Cr) for the preconcentration of phosphorylated peptides. MICROCHIMICA ACTA, 183 (7): (2235-2240). [PMID:] [10.1007/s00604-016-1860-1] |
44. Guihua Ruan, Zhenwei Wu, Yipeng Huang, Meiping Wei, Rihui Su, Fuyou Du. (2016) An easily regenerable enzyme reactor prepared from polymerized high internal phase emulsions. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 473 (54). [PMID:26995089] [10.1016/j.bbrc.2016.03.049] |
45. Du Yan, Wu Dapeng, Wu Qian, Guan Yafeng. (2015) Quantitative evaluation of peptide-extraction methods by HPLC–triple-quad MS–MS. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407 (6): (1595-1605). [PMID:25542575] [10.1007/s00216-014-8389-0] |
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