IOX2 - ≥98%, high purity , CAS No.931398-72-0, Inhibitor of egl-9 family hypoxia inducible factor 1;Inhibitor of lysine demethylase 2A;Inhibitor of lysine demethylase 5C

Item Number

I127127

Grouped product items
SKU	Size	Availability	Price
I127127-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$98.90
I127127-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$445.90
I127127-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,603.90

Potent, cell-permeable, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor

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Synonyms	BCP06141 \| sodium (1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycinate \| CS-0988 \| NCGC00344625-13 \| EX-A099 \| HMS3426G15 \| NCGC00344625-02 \| CHEBI:95087 \| FT-0746473 \| IOX2, >=98% (HPLC) \| AKOS024458165 \| N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD). Stabilization of HIF-1R through inhibition of PHD has been examined as a potential treatment for ischemic diseases including anemia, myocardial infarction, and stroke. IOX2 is a selectiv
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of egl-9 family hypoxia inducible factor 1;Inhibitor of lysine demethylase 2A;Inhibitor of lysine demethylase 5C
Note	Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.

IUPAC Name	2-[(1-benzyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]acetic acid
INCHI	InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)
InChi Key	CAOSCCRYLYQBES-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O
Isomeric SMILES	C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O
WGK Germany	3
PubChem CID	54685215
Molecular Weight	352.34

Lot Number	Certificate Type	Date	Item
E1705098	Certificate of Analysis	Sep 11, 2024	I127127
L2326038	Certificate of Analysis	Jan 03, 2024	I127127

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
WGK Germany	3

Basic Description