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IOX4 - 10mM in DMSO, high purity , CAS No.1154097-71-8
Basic Description Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms IOX4 is a potent and selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with IC50 of 1.6 nM. IOX4 induces HIFα in various mouse tissues and human cell lines. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Information
IOX4 IOX4 is a potent and selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with IC50 of 1.6 nM. IOX4 induces HIFα in various mouse tissues and human cell lines.
Targets
HIF-1α ; HIF-2α ; PHD2 (Cell-free assay) ; 1.6 nM
Product Properties ALogP 0.137 HBD Count 1 Rotatable Bond 5
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name tert-butyl 6-[3-oxo-4-(triazol-1-yl)-1H-pyrazol-2-yl]pyridine-3-carboxylate INCHI InChI=1S/C15H16N6O3/c1-15(2,3)24-14(23)10-4-5-12(16-8-10)21-13(22)11(9-18-21)20-7-6-17-19-20/h4-9,18H,1-3H3 InChi Key HWQQDVNGHZIALS-UHFFFAOYSA-N Canonical SMILES CC(C)(C)OC(=O)C1=CN=C(C=C1)N2C(=O)C(=CN2)N3C=CN=N3 Isomeric SMILES CC(C)(C)OC(=O)C1=CN=C(C=C1)N2C(=O)C(=CN2)N3C=CN=N3 PubChem CID 24812792 Molecular Weight 328.33
Chemical and Physical Properties DMSO(mg / mL) Max Solubility 66 DMSO(mM) Max Solubility 201.017269210855 Water(mg / mL) Max Solubility ＜1
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P301+P312: IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.
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