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IPA-3 - 95%, high purity , CAS No.42521-82-4, Inhibitor of p21 (RAC1) activated kinase 1

Moligand™
≥95%

CAS#: 42521-82-4
Formula: C₂₀H₁₄O₂S₂
Molecular Weight: 350.45
MDL number: MFCD00388917
PubChem CID: 521106

Item Number

I125982

Grouped product items
SKU	Size	Availability	Price
I125982-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$38.90
I125982-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$112.90
I125982-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$205.90
I125982-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$369.90

Group I, p21-activated kinase (PAK) inhibitor

View related series

p21 (RAC1) activated kinase 1 Inhibitor

Basic Description

Synonyms	IPA-3\|42521-82-4\|IPA 3\|Bis(2-hydroxy-1-naphthyl) disulfide\|1,1'-Dithiodi-2-naphthol\|1,1'-disulfanediylbis(naphthalen-2-ol)\|IPA3\|2-Naphthol, 1,1'-dithiodi-\|2-Naphthalenol, 1,1'-dithiobis-\|1-[(2-hydroxynaphthalen-1-yl)disulfanyl]naphthalen-2-ol\|3XFG6MQ9G2\|C
Specifications & Purity	95%
Storage Temp	Store at 2-8°C,Protected from light
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of p21 (RAC1) activated kinase 1
Product Description	IPA-3

Names and Identifiers

IUPAC Name	1-[(2-hydroxynaphthalen-1-yl)disulfanyl]naphthalen-2-ol
INCHI	InChI=1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H
InChi Key	RFAXLXKIAKIUDT-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C=CC(=C2SSC3=C(C=CC4=CC=CC=C43)O)O
Isomeric SMILES	C1=CC=C2C(=C1)C=CC(=C2SSC3=C(C=CC4=CC=CC=C43)O)O
WGK Germany	3
PubChem CID	521106
Molecular Weight	350.45

PubChem CID

521106

CAS Registry No.

42521-82-4

ChEMBL Ligand

CHEMBL472940

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number	Certificate Type	Date	Item
L2314362	Certificate of Analysis	Nov 25, 2023	I125982
L2314363	Certificate of Analysis	Nov 25, 2023	I125982
L2314364	Certificate of Analysis	Nov 25, 2023	I125982
L2314365	Certificate of Analysis	Nov 25, 2023	I125982
L2314366	Certificate of Analysis	Nov 25, 2023	I125982
L2314367	Certificate of Analysis	Nov 25, 2023	I125982
L2314368	Certificate of Analysis	Nov 25, 2023	I125982
L2314369	Certificate of Analysis	Nov 25, 2023	I125982

Solubility

DMSO 70 mg/mL Water <1 mg/mL Ethanol 7 mg/mL

Sensitivity

light sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS05
Signal	Danger
Hazard Statements	H318:Causes serious eye damage H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ...
WGK Germany	3

References

1. Viaud J, Peterson JR. (2009) An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently.. Mol Cancer Ther, 8 (9): (2559-65). [PMID:19723886]
2. Deacon SW, Beeser A, Fukui JA, Rennefahrt UE, Myers C, Chernoff J, Peterson JR. (2008) An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase.. Chem Biol, 15 (4): (322-31). [PMID:18420139]
3. Liu JS et al.. (2015) ß-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation.. World J Gastroenterol, 21 (34): (9945-56). [PMID:26379399]

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IPA-3 - 95%, high purity , CAS No.42521-82-4, Inhibitor of p21 (RAC1) activated kinase 1

Basic Description

Associated Targets

PAK1 Tchem Serine/threonine-protein kinase PAK 1 1 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

References

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