IPA-3 is an allosteric inhibitor of Pak1. It binds to autoinhibitory domain of Pak1 (p21 activated kinase), highly selective amongst kinases. Pak1 is implicated in tumorigenesis and metastasis.
Storage Temp
Store at 2-8°C,Protected from light
Shipped In
Wet ice
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of p21 (RAC1) activated kinase 1
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
IPA-3
Associated Targets(Human)
PAK1TchemSerine/threonine-protein kinase PAK 1 (1 Activities)
1.Viaud J, Peterson JR. (2009) An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently.. Mol Cancer Ther, 8 (9):(2559-65). [PMID:19723886][10.1021/op500134e]
2.Deacon SW, Beeser A, Fukui JA, Rennefahrt UE, Myers C, Chernoff J, Peterson JR. (2008) An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase.. Chem Biol, 15 (4):(322-31). [PMID:18420139][10.1021/op500134e]
3.Liu JS et al.. (2015) ß-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation.. World J Gastroenterol, 21 (34):(9945-56). [PMID:26379399]
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