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Ipilimumab (anti-CTLA-4), for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to CTLA-4/CD152, >95% (SDS-PAGE&SEC), high purity, Human IgG1, Antibody of cytotoxic T-lymphocyte-associated protein 4 (CD152)

≥95%(SDS-PAGE&SEC)
Lot by Lot

Features and benefits

Short Overview:
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<0.01EU/μg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Application: ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Species reactivity(Reacts with): Cynomolgus monkey,Human,Mouse
Isotype: Human IgG1

Application:

Animal Model
ELISA
Flow Cytometry
Functional Assay

Item Number

I411993

Grouped product items
SKU	Size	Availability	Price
I411993-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$179.90
I411993-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$897.90
I411993-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,538.90
I411993-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,570.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<0.01EU/μg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series

Click to view target information: CTLA4

Accession#:P16410 CTLA4 cytotoxic T-lymphocyte-associated protein 4 (CD152) Antibody Gene ID:1493

Basic Description

Product Name	Ipilimumab (anti-CTLA-4), for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to CTLA-4/CD152, >95% (SDS-PAGE&SEC), high purity, Human IgG1
Synonyms	70131-50-9\|8007-00-9\|477202-00-9\|8024-01-9\|851615-05-9
Specifications & Purity	ExactAb™, Validated, Carrier Free, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
Specificity	CTLA-4/CD152
Application	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Recombinant, Validated
Action Type	INHIBITOR
Mechanism of action	Antibody of cytotoxic T-lymphocyte-associated protein 4 (CD152)
Product Description	Ipilimumab (anti-CTLA-4) is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4; It is also an immune checkpoint inhibitor. Purity>95% (SDS-PAGE&SEC) Endotoxin Level< 0.01EU/μg

Product Properties

Antibody Type	Primary antibody
Clonality	Recombinant
Isotype	Human IgG1
SDS-PAGE	26.9 kDa (Light Chain) & 52.7 kDa (Heavy Chain), under reducing conditions; 176.3 kDa, under non-reducing conditions.
Purification Method	Protein A purified
Purity	>95% (SDS-PAGE&SEC)
Source	CHO supernatant
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	477202-00-9

Images

Ipilimumab (anti-CTLA-4) (I411993) - ELISA
Immobilized Hu-CTLA-4-His at 2 μg/mL can bind Ipilimumab (anti-CTLA-4) (I411993) with the EC₅₀ of 6.69 ng/mL.

Ipilimumab (anti-CTLA-4) (I411993) - SEC
The purity of Ipilimumab (anti-CTLA-4) (I411993) is more than 95% verified by HPLC.

Ipilimumab (anti-CTLA-4) (I411993) - ELISA
Immobilized Recombinant Human CTLA4 protein (rp176276) at 1.0 μg/mL can bind Ipilimumab (anti-CTLA-4) (I411993) with the EC₅₀ of 19.03 ng/mL.

Associated Targets(Human)

CTLA4 Tclin Cytotoxic T-lymphocyte protein 4 (0 Activities)

Discover Target: CTLA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CTLA4 Tclin Cytotoxic T-lymphocyte protein 4 (1 Activities)

Discover Target: CTLA4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IMGT/mAb-DB

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Wikipedia

Ipilimumab

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0404213	Certificate of Analysis	Apr 08, 2024	I411993
ZJ24F0404212	Certificate of Analysis	Apr 08, 2024	I411993
ZJ24F0404214	Certificate of Analysis	Apr 08, 2024	I411993

References

1. Postow MA, Chesney J, Pavlick AC, Robert C, Grossmann K, McDermott D, Linette GP, Meyer N, Giguere JK, Agarwala SS et al.. (2015) Nivolumab and ipilimumab versus ipilimumab in untreated melanoma.. N Engl J Med, 372 (21): (2006-17). [PMID:25891304]
2. Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Cowey CL, Lao CD, Schadendorf D, Dummer R, Smylie M, Rutkowski P et al.. (2015) Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.. N Engl J Med, 373 (1): (23-34). [PMID:26027431]
3. Motzer RJ, Tannir NM, McDermott DF, Arén Frontera O, Melichar B, Choueiri TK, Plimack ER, Barthélémy P, Porta C, George S et al.. (2018) Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma.. N Engl J Med, 378 (14): (1277-1290). [PMID:29562145]

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