Irbesartan - ≥98%, high purity , CAS No.138402-11-6, Antagonist of AT 1 receptor;Inhibitor of Sodium/bile acid and sulphated solute cotransporter 1

Item Number

I129263

• Synonyms: BMS-186295 | IRBESARTAN [VANDF] | Irbesartan- Bio-X | HY-B0202 | Irbesartan [USAN:USP:INN:BAN] | NSC758696 | NSC-758696 | BCPP000202 | SR-47436 | 2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one | HMS2232F23 | Avapr
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Irbesartan is a highly potent and selective antagonist of the AT1 (angiotensin II type 1) receptor with an IC50 = 1.3 nM. This compound has no affinity for AT2 receptors. Pretreatment with irbesartan decreases angiotensin II-induced apoptosis in rat vascu
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: ANTAGONIST, INHIBITOR
• Mechanism of action: Antagonist of AT 1 receptor;Inhibitor of Sodium/bile acid and sulphated solute cotransporter 1
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Product Describtion:

Irbesartan (SR-47436, BMS-186295) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.
An angiotensin II type 1 (AII1)-receptor antagonist.

Product Application:

Irbesartan has been used as an angiotensin II receptor type 1 (ATR1) blocker in carotid atheroma tissue. It may be used to test its effect on allergic asthma in rat and mice mast cells.