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Irinotecan HCl Trihydrate - ≥98%, high purity , DNA topoisomerase I inhibitor, CAS No.136572-09-3, DNA topoisomerase I inhibitor
Basic Description Synonyms IRINOTECAN HYDROCHLORIDE [ORANGE BOOK] | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;trihydrate;hydrochloride | Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Irinotecan hydrochloride trihydrate, Irinotecan (CPT 11), a compound within the camptothecin family, is an inhibitor of Topo I (topoisomerase I) involved in cellular DNA replication and transcription. As a Topo I inhibitor, Irinotecan inhibits the religat Storage Temp Store at 2-8°C Shipped In Wet ice Action Type INHIBITOR Mechanism of action DNA topoisomerase I inhibitor Product Description Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;trihydrate;hydrochloride INCHI InChI=1S/C33H38N4O6.ClH.3H2O/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;;;;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H;3*1H2/t33-;;;;/m0..../s1 InChi Key KLEAIHJJLUAXIQ-JDRGBKBRSA-N Canonical SMILES CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.O.O.O.Cl Isomeric SMILES CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.O.O.O.Cl RTECS DW1060750 PubChem CID 60837 Molecular Weight 677.18 Reaxy-Rn 4838283
Chemical and Physical Properties Solubility DMSO 135 mg/mL Water 2 mg/mL Ethanol 7 mg/mL Sensitivity Heat sensitive Specific Rotation[α] 24° (C=1,MeOH) Boil Point(°C) 257°C
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS07 Signal Danger Hazard Statements H341: Suspected of causing genetic defects
H302: Harmful if swallowed
H360: May damage fertility or the unborn child
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P281: Use personal protective equipment as required.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P203: Obtain, read and follow all safety instructions before use.
P301+P317: IF SWALLOWED: Get medical help.
P318: if exposed or concerned, get medical advice.
RTECS DW1060750 Reaxy-Rn 4838283 Merck Index 5091
Citations of This Product 1. Xinxin Meng, Zhun Liu, Xubin Qian, Shaoyu Tang, Cheng Fang, Junfeng Niu, Lei Xu. (2023) Enhanced degradation mechanism of anticancer drug irinotecan through low-frequency ultrasound assisted reactive electrochemical membrane. Journal of Cleaner Production, 383 (135419). [PMID: [10.1016/j.jclepro.2022.135419 ]
References 1. Xinxin Meng, Zhun Liu, Xubin Qian, Shaoyu Tang, Cheng Fang, Junfeng Niu, Lei Xu. (2023) Enhanced degradation mechanism of anticancer drug irinotecan through low-frequency ultrasound assisted reactive electrochemical membrane. Journal of Cleaner Production, 383 (135419). [PMID: [10.1016/j.jclepro.2022.135419 ]
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