Basic Description

Synonyms	Irinotecan hydrochloride \| 100286-90-6 \| Irinotecan Hcl \| Topotecin \| Campto \| Camptothecin 11 hydrochloride \| Camptosar \| CPT 11 \| CPT-11 \| Camptothecin 11 \| Irinotecan (hydrochloride) \| U 101440E \| UNII-06X131E4OE \| CHEBI:5971 \| DTXSID6045953 \| 06X131E4OE \| (S)-4,11-diethyl-4-hydroxy-
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Irinotecan is a prodrug, which is converted to 7-ethyl-10-hydroxycamptothecin (SN-38), an effective inhibitor of DNA topoisomerase I, under the action of tissue carboxylesterase. The effect of UDP glucuronidase can be terminated by glucuronization. Irinot
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Irinotecan hydrochloride has been used: • in combination with 5-fluorouracil for screening growth inhibitory functionality in MDA-MB-231 breast cancer cells. • in chemosensitivity screening of high-grade appendiceal (HGA) and low-grade appendiceal (LGA) organoids. • as a chemotherapeutic agent in the cytotoxicity studies in combination with heat shock proteins inhibitors (HPSC1) in HT29 colon cancer cells.

Associated Targets(Human)

GMNN Tbio Geminin (0 Activities)

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FTL Tbio Ferritin light chain (0 Activities)

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HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 (0 Activities)

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KAT2A Tchem Histone acetyltransferase KAT2A (0 Activities)

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SMN1 Tchem Survival motor neuron protein (0 Activities)

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PMP22 Tbio Peripheral myelin protein 22 (0 Activities)

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (0 Activities)

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LMNA Tbio Prelamin-A/C (0 Activities)

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GAA Tclin Lysosomal alpha-glucosidase (0 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)

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GLA Tclin Alpha-galactosidase A (0 Activities)

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ALDH1A1 Tchem Retinal dehydrogenase 1 (0 Activities)

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KDM4E Tchem Lysine-specific demethylase 4E (0 Activities)

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GLA Tclin Alpha-galactosidase A (5444 Activities)

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GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)

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GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)

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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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A498 (42825 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DLD-1 (17511 Activities)

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DMS-273 (14108 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MOLT-4 (49676 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

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Raji (5516 Activities)

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RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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UACC-257 (46019 Activities)

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UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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XF498 (12972 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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T47D (39041 Activities)

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EKVX (44102 Activities)

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NCI-H322M (45589 Activities)

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HCC 2998 (41480 Activities)

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HCT-116 (91556 Activities)

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HOP-18 (11577 Activities)

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HOP-92 (41141 Activities)

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Associated Targets(non-human)

Cruzipain (33337 Activities)

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Mus musculus (284745 Activities)

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P388/ADR (1216 Activities)

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GCN5 Histone acetyltransferase GCN5 (89 Activities)

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FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;hydrochloride
INCHI	InChI=1S/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0./s1
InChi Key	GURKHSYORGJETM-WAQYZQTGSA-N
Canonical SMILES	CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.Cl
Isomeric SMILES	CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.Cl
WGK Germany	3
PubChem CID	74990
Molecular Weight	623.14

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Sensitivity	heat sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Jia Cui, Ziyi Zhang, Han Zhong, Tao Zhang. (2023) Phosphorylcholine-grafted graphene oxide loaded with irinotecan for potential oncology therapy. RSC Advances, 13 (41): (28642-28651). [PMID:37790105] [10.1039/D3RA04987F]
2. Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang, Orlando J. Rojas, Yong Zeng, Junling Guo. (2023) Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels. JOURNAL OF CONTROLLED RELEASE, 360 (433). [PMID:37422124] [10.1016/j.jconrel.2023.07.003]
3. Tan Xi, Wang Chenhui, Zhou Hong, Zhang Shuting, Liu Xuhan, Yang Xiangliang, Liu Wei. (2023) Bioactive fatty acid analog-derived hybrid nanoparticles confer antibody-independent chemo-immunotherapy against carcinoma. JOURNAL OF NANOBIOTECHNOLOGY, 21 (1): (1-15). [PMID:37291573] [10.1186/s12951-023-01950-y]
4. Fei Wang, Xuyang Li, Xialin Hu, Wenya Zhuang, Jiewei Lai, Wenchao Wang, Xuanrong Sun, Hong Wang, Qingyong Li. (2022) Preparation and evaluation of camptothecin analogues-loaded lyophilization using Kolliphor® HS 15 as carrier. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 77 (103898). [PMID:] [10.1016/j.jddst.2022.103898]
5. Wang Yi, Wang Wenchao, Yu Endian, Zhuang Wenya, Sun Xuanrong, Wang Hong, Li Qingyong. (2022) Preparation of a camptothecin analog FLQY2 self-micelle solid dispersion with improved solubility and bioavailability. JOURNAL OF NANOBIOTECHNOLOGY, 20 (1): (1-15). [PMID:36064403] [10.1186/s12951-022-01596-2]

References

1. Jia Cui, Ziyi Zhang, Han Zhong, Tao Zhang. (2023) Phosphorylcholine-grafted graphene oxide loaded with irinotecan for potential oncology therapy. RSC Advances, 13 (41): (28642-28651). [PMID:37790105] [10.1039/D3RA04987F]
2. Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang, Orlando J. Rojas, Yong Zeng, Junling Guo. (2023) Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels. JOURNAL OF CONTROLLED RELEASE, 360 (433). [PMID:37422124] [10.1016/j.jconrel.2023.07.003]
3. Tan Xi, Wang Chenhui, Zhou Hong, Zhang Shuting, Liu Xuhan, Yang Xiangliang, Liu Wei. (2023) Bioactive fatty acid analog-derived hybrid nanoparticles confer antibody-independent chemo-immunotherapy against carcinoma. JOURNAL OF NANOBIOTECHNOLOGY, 21 (1): (1-15). [PMID:37291573] [10.1186/s12951-023-01950-y]
4. Fei Wang, Xuyang Li, Xialin Hu, Wenya Zhuang, Jiewei Lai, Wenchao Wang, Xuanrong Sun, Hong Wang, Qingyong Li. (2022) Preparation and evaluation of camptothecin analogues-loaded lyophilization using Kolliphor® HS 15 as carrier. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 77 (103898). [PMID:] [10.1016/j.jddst.2022.103898]
5. Wang Yi, Wang Wenchao, Yu Endian, Zhuang Wenya, Sun Xuanrong, Wang Hong, Li Qingyong. (2022) Preparation of a camptothecin analog FLQY2 self-micelle solid dispersion with improved solubility and bioavailability. JOURNAL OF NANOBIOTECHNOLOGY, 20 (1): (1-15). [PMID:36064403] [10.1186/s12951-022-01596-2]

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Irinotecan hydrochloride - 10mM in DMSO, high purity , CAS No.100286-90-6

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

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Dilution Calculator

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