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Irinotecan hydrochloride - 10mM in DMSO, high purity , CAS No.100286-90-6

10mM in DMSO

CAS#: 100286-90-6
Formula: C₃₃H₃₈N₄O₆ · HCl
Molecular Weight: 623.14
PubChem CID: 74990

Item Number

I420259

Grouped product items
SKU	Size	Availability	Price	Qty
I420259-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$69.90

Potent DNA topoisomerase I inhibitor

Basic Description

Synonyms	Irinotecan hydrochloride\|100286-90-6\|Irinotecan Hcl\|Topotecin\|Campto\|Camptothecin 11 hydrochloride\|Camptosar\|CPT 11\|CPT-11\|Camptothecin 11\|Irinotecan (hydrochloride)\|U 101440E\|UNII-06X131E4OE\|CHEBI:5971\|DTXSID6045953\|06X131E4OE\|(S)-4,11-diethyl-4-hydroxy-
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Irinotecan is a prodrug, which is converted to 7-ethyl-10-hydroxycamptothecin (SN-38), an effective inhibitor of DNA topoisomerase I, under the action of tissue carboxylesterase. The effect of UDP glucuronidase can be terminated by glucuronization. Irinot
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Irinotecan hydrochloride has been used: • in combination with 5-fluorouracil for screening growth inhibitory functionality in MDA-MB-231 breast cancer cells. • in chemosensitivity screening of high-grade appendiceal (HGA) and low-grade appendiceal (LGA) organoids. • as a chemotherapeutic agent in the cytotoxicity studies in combination with heat shock proteins inhibitors (HPSC1) in HT29 colon cancer cells.

Associated Targets

GMNN Tbio Geminin 0 Activities

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FTL Tbio Ferritin light chain 0 Activities

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HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

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KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities

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SMN1 Tchem Survival motor neuron protein 0 Activities

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PMP22 Tbio Peripheral myelin protein 22 0 Activities

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

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LMNA Tbio Prelamin-A/C 0 Activities

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GAA Tclin Lysosomal alpha-glucosidase 0 Activities

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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GLA Tclin Alpha-galactosidase A 0 Activities

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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

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KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

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Names and Identifiers

IUPAC Name	[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;hydrochloride
INCHI	InChI=1S/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0./s1
InChi Key	GURKHSYORGJETM-WAQYZQTGSA-N
Canonical SMILES	CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.Cl
Isomeric SMILES	CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.Cl
WGK Germany	3
PubChem CID	74990
Molecular Weight	623.14

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3

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