ISA-2011B , CAS No.I611156, Inhibitor of phosphatidylinositol-4-phosphate 5-kinase type 1 alpha

Item Number

I611156

Grouped product items
SKU	Size	Availability	Price
I611156-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$97.90
I611156-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$240.90
I611156-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$846.90

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Basic Description

Specifications & Purity	≥98%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	Inhibitor of phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Product Description	ISA-2011B is an inhibitor of PIP5K1α and can be used in anticancer studies.

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S,8S)-2-(5-chloro-1H-indol-3-yl)-6-methyl-13,15-dioxa-3,6-diazatetracyclo[8.7.0.03,8.012,16]heptadeca-1(17),10,12(16)-triene-4,7-dione
INCHI	InChI=1S/C22H18ClN3O4/c1-25-9-20(27)26-17(22(25)28)4-11-5-18-19(30-10-29-18)7-13(11)21(26)15-8-24-16-3-2-12(23)6-14(15)16/h2-3,5-8,17,21,24H,4,9-10H2,1H3/t17-,21-/m0/s1
InChi Key	FSEZESVJDPKRDS-UWJYYQICSA-N
Canonical SMILES	CN1CC(=O)N2C(C1=O)CC3=CC4=C(C=C3C2C5=CNC6=C5C=C(C=C6)Cl)OCO4
Isomeric SMILES	CN1CC(=O)N2[C@H](C1=O)CC3=CC4=C(C=C3[C@H]2C5=CNC6=C5C=C(C=C6)Cl)OCO4
PubChem CID	49853637
MeSH Entry Terms	ISA-2011B
Molecular Weight	423.85

References

1. Saito K, Tolias KF, Saci A, Koon HB, Humphries LA, Scharenberg A, Rawlings DJ, Kinet JP, Carpenter CL. (2003) BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity.. Immunity, 19 (5): (669-78). [PMID:14614854]
2. Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. (2005) Exploiting the PI3K/AKT pathway for cancer drug discovery.. Nat Rev Drug Discov, 4 (12): (988-1004). [PMID:16341064]
3. Semenas J, Hedblom A, Miftakhova RR, Sarwar M, Larsson R, Shcherbina L, Johansson ME, Härkönen P, Sterner O, Persson JL. (2014) The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer.. Proc Natl Acad Sci USA, 111 (35): (E3689-98). [PMID:25071204]
4. Loijens JC, Anderson RA. (1996) Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family.. J Biol Chem, 271 (51): (32937-43). [PMID:8955136]

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Basic Description