Call +1 (833) 552-7181 or Contact us Earn $25 in coupons on your first order with Aladdin!
Toggle Nav
My Cart
Search
Advanced Search
Menu
Sign In
྾
main product photo

ISA-2011B , CAS No.I611156, Inhibitor of phosphatidylinositol-4-phosphate 5-kinase type 1 alpha

  • ≥98%
Item Number
I611156
Grouped product items
SKUSizeAvailabilityPrice Qty
I611156-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$97.90
I611156-5mg
5mg
In stock
$240.90
I611156-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$715.90
Add to Wish List Compare
Bulk Order  SDS  DATASHEET
View related series
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha Inhibitor

Basic Description

Specifications & Purity≥98%
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
Action TypeINHIBITOR
Mechanism of actionInhibitor of phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Product Description

ISA-2011B is an inhibitor of PIP5K1α and can be used in anticancer studies.

Associated Targets(Human)

PIP5K1A Tbio Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Caco-2 (12174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-937 (7138 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LNCaP (8286 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CWR22R (2180 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MARK4 Tchem MAP/microtubule affinity-regulating kinase 4 (1536 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PIP5K1A Tbio Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (308 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MARK1 Tchem Serine/threonine-protein kinase MARK1 (1633 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S,8S)-2-(5-chloro-1H-indol-3-yl)-6-methyl-13,15-dioxa-3,6-diazatetracyclo[8.7.0.03,8.012,16]heptadeca-1(17),10,12(16)-triene-4,7-dione
INCHI InChI=1S/C22H18ClN3O4/c1-25-9-20(27)26-17(22(25)28)4-11-5-18-19(30-10-29-18)7-13(11)21(26)15-8-24-16-3-2-12(23)6-14(15)16/h2-3,5-8,17,21,24H,4,9-10H2,1H3/t17-,21-/m0/s1
InChi Key FSEZESVJDPKRDS-UWJYYQICSA-N
Canonical SMILES CN1CC(=O)N2C(C1=O)CC3=CC4=C(C=C3C2C5=CNC6=C5C=C(C=C6)Cl)OCO4
Isomeric SMILES CN1CC(=O)N2[C@H](C1=O)CC3=CC4=C(C=C3[C@H]2C5=CNC6=C5C=C(C=C6)Cl)OCO4
PubChem CID 49853637
MeSH Entry Terms ISA-2011B
Molecular Weight 423.85

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot NumberCertificate TypeDateItem
J2421549Certificate of AnalysisOct 17, 2024 I611156
J2421550Certificate of AnalysisOct 17, 2024 I611156
J2421551Certificate of AnalysisOct 17, 2024 I611156
J2421552Certificate of AnalysisOct 17, 2024 I611156
J2421553Certificate of AnalysisOct 17, 2024 I611156

Chemical and Physical Properties

SolubilityDMSO: 100 mg/mL (235.93 mM), Sonication is recommended.

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. ISA-2011B
    ISA-2011B
    • 10mM in DMSO

    Starting at $249.90

References

1. Saito K, Tolias KF, Saci A, Koon HB, Humphries LA, Scharenberg A, Rawlings DJ, Kinet JP, Carpenter CL.  (2003)  BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity..  Immunity,  19  (5): (669-78).  [PMID:14614854]
2. Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB.  (2005)  Exploiting the PI3K/AKT pathway for cancer drug discovery..  Nat Rev Drug Discov,  4  (12): (988-1004).  [PMID:16341064]
3. Semenas J, Hedblom A, Miftakhova RR, Sarwar M, Larsson R, Shcherbina L, Johansson ME, Härkönen P, Sterner O, Persson JL.  (2014)  The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer..  Proc Natl Acad Sci USA,  111  (35): (E3689-98).  [PMID:25071204]
4. Loijens JC, Anderson RA.  (1996)  Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family..  J Biol Chem,  271  (51): (32937-43).  [PMID:8955136]

Solution Calculators

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.