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ISAM 140 - ≥98%(HPLC), high purity , CAS No.932191-62-3, Antagonist of A 2B receptor
High affinity A2Breceptor antagonist
Basic Description
| Specifications & Purity | Moligand™, ≥98%(HPLC) |
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| Biochemical and Physiological Mechanisms | ISAM-140 (22b) is a potent and highly selective A2B adenosine receptor antagonist with a Ki of 3.49 nM.
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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| Grade | Moligand™ |
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| Action Type | ANTAGONIST |
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| Mechanism of action | Antagonist of A 2B receptor |
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Associated Targets(Human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| Pubchem Sid | 488199473 |
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| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488199473 |
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| IUPAC Name | propan-2-yl 4-(furan-2-yl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate |
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| INCHI | InChI=1S/C19H19N3O3/c1-11(2)25-18(23)16-12(3)20-19-21-13-7-4-5-8-14(13)22(19)17(16)15-9-6-10-24-15/h4-11,17H,1-3H3,(H,20,21) |
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| InChi Key | NYHLRBMDXQBOIB-UHFFFAOYSA-N |
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| Canonical SMILES | CC1=C(C(N2C3=CC=CC=C3N=C2N1)C4=CC=CO4)C(=O)OC(C)C |
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| Isomeric SMILES | CC1=C(C(N2C3=CC=CC=C3N=C2N1)C4=CC=CO4)C(=O)OC(C)C |
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| PubChem CID | 17198004 |
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| Molecular Weight | 337.37 |
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Chemical and Physical Properties
| Solubility | Solvent:DMSO, Max Conc. mg/mL: 6.75, Max Conc. mM: 20 |
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References
| 1. El Maatougui A, Azuaje J, González-Gómez M, Miguez G, Crespo A, Carbajales C, Escalante L, García-Mera X, Gutiérrez-de-Terán H, Sotelo E. (2016) Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes.. J Med Chem, 59 (5): (1967-83). [PMID:26824742] [10.1021/op500134e] |
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