Grouped product items

SKU

Size

Availability

Price

Qty

I104665-25g

25g

In stock

$31.90

I104665-100g

100g

In stock

$65.90

I104665-500g

500g

Available within 4-8 weeks(?)

$223.90

Basic Description

Synonyms	Isatin \| 91-56-5 \| 1H-Indole-2,3-dione \| 2,3-Indolinedione \| Indoline-2,3-dione \| INDOLE-2,3-DIONE \| Isatine \| Tribulin \| Pseudoisatin \| 2,3-Dioxoindoline \| 2,3-Diketoindoline \| Isatic acid lactam \| Isotin \| Isatinic acid anhydride \| 2,3-Ketoindoline \| o-Aminobenzoylformic anhydride \| 2
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Selective endogenous MAOB inhibitor and potent ANP receptor antagonist (IC 50 = 3-8 and 0.4 μM respectively). Inhibits alkaline phosphatase and (NO-stimulated soluble guanylate cyclase. Anxiolytic, sedative, anticonvulsant and antidiuretic effects in vivo
Storage Temp	Desiccated
Shipped In	Normal
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Isatin is an endogenous monoamine oxidase (MAO) inhibitor involved in stress and anxiety. Additionally, isatin inhibits alkaline phosphatase (ALP), nitric oxide (NO)-stimulated soluble guanylate cyclase, and other enzymes. An endogenous monoamine oxidase inhibitor.

Associated Targets(Human)

MAOB Tclin Amine oxidase [flavin-containing] B (1 Activities)

Discover Target: MAOB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Monoamine oxidase A (11911 Activities)

Discover Target: MAOA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOB Tclin Monoamine oxidase B (8835 Activities)

Discover Target: MAOB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CASP3 Tchem Caspase-3 (3632 Activities)

Discover Target: CASP3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BCHE Tclin Butyrylcholinesterase (7174 Activities)

Discover Target: BCHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CES1 Tchem Acyl coenzyme A:cholesterol acyltransferase (1029 Activities)

Discover Target: CES1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TGM2 Tchem Protein-glutamine gamma-glutamyltransferase (1221 Activities)

Discover Target: TGM2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HT-29 (80576 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

K562 (73714 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MRC5 (9203 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PC-3 (62116 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-N-SH (1499 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U-937 (7138 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCI-H460 (60772 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Jurkat (10389 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-231 (73002 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SW-620 (52400 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ASPC1 (1310 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DAO Tchem D-amino-acid oxidase (802 Activities)

Discover Target: DAO

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Ttr Transthyretin (14 Activities)

Discover Target: Ttr

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cruzipain (33337 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALS Acetolactate synthase (354 Activities)

Discover Target: ALS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mycobacterium tuberculosis (203094 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meloidogyne incognita (862 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BCHE Cholinesterase (8742 Activities)

Discover Target: BCHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Falcipain 2 (539 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Brassica rapa subsp. oleifera (1696 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1H-indole-2,3-dione
INCHI	InChI=1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11)
InChi Key	JXDYKVIHCLTXOP-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C(=O)C(=O)N2
Isomeric SMILES	C1=CC=C2C(=C1)C(=O)C(=O)N2
WGK Germany	1
RTECS	NL7873000
PubChem CID	7054
Molecular Weight	147.13
Beilstein	383659
Reaxy-Rn	383659

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

7 results found

Lot Number	Certificate Type	Date	Item
J2014139	Certificate of Analysis	Aug 16, 2024	I104665
I2203305	Certificate of Analysis	Jul 07, 2022	I104665
I2203306	Certificate of Analysis	Jul 07, 2022	I104665
I2203307	Certificate of Analysis	Jul 07, 2022	I104665
I2203308	Certificate of Analysis	Jul 07, 2022	I104665
B2308085	Certificate of Analysis	Oct 18, 2021	I104665
B2308994	Certificate of Analysis	Oct 18, 2021	I104665

Chemical and Physical Properties

Solubility	Soluble in water (1.9 g/l at 20 °C).
Flash Point(°F)	220 °C
Flash Point(°C)	220°C
Melt Point(°C)	203.5°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	1
RTECS	NL7873000
Reaxy-Rn	383659
Merck Index	5104

Citations of This Product

1. Qian Wang, Lei Huang, Jiayu Guan, Linjian Sang, Jifu Zheng, Qifeng Zhang, Guorui Qin, Shenghai Li, Suobo Zhang. (2023) Side chain sulfonic acid polymers with intrinsic pores in the main chain as proton exchange membranes for fuel cells and redox flow battery. JOURNAL OF MEMBRANE SCIENCE, 687 (122036). [PMID:]
2. Hukang Guo, Fupeng Li, Xuerong Shui, Jianyu Wang, Chuanjie Fang, Liping Zhu. (2023) Ultrathin Polyamide Nanofilms with Controlled Microporosity for Enhanced Solvent Permeation. ACS Applied Materials & Interfaces, 15 (30): (37077–37085). [PMID:37479673]
3. Sisheng Fang, Hai Tang, Meng Wang, Zhaozan Xu, Nanwen Li. (2023) The antifouling and separation performance of an ultrafiltration membrane derived from a novel amphiphilic copolymer containing a crown ether. JOURNAL OF MEMBRANE SCIENCE, 676 (121620). [PMID:]
4. Jiangru Wang, Yan Yang, Qirui Shen, Dazhong Shen, Qi Kang. (2023) A smartphone-based long optical path colorimetric turntable for selective determination of malachite green and investigation the specific adsorption behavior of the imprinted cavities within molecularly imprinted polymers. MICROCHEMICAL JOURNAL, 190 (108629). [PMID:]
5. Yanqing Li, Yingwu Lin, Fang Wang, Jinghan Wang, Osami Shoji, Jiakun Xu. (2023) Construction of Biocatalysts Using the P450 Scaffold for the Synthesis of Indigo from Indole. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (3): (2395). [PMID:36768714]
6. Qian Wang, Lei Huang, Zimo Wang, Jifu Zheng, Qifeng Zhang, Guorui Qin, Shenghai Li, Suobo Zhang. (2022) High Conductive Anion Exchange Membranes from All-Carbon Twisted Intrinsic Microporous Polymers. MACROMOLECULES, 55 (23): (10713–10722). [PMID:]
7. Qing Fang, Qin Liu, Zongli Xie, Matthew R. Hill, Kaisong Zhang. (2023) Two dimensional laminar MoS2 modified PTMSP membranes with improved organic solvent nanofiltration performance. JOURNAL OF MEMBRANE SCIENCE, 666 (121139). [PMID:]
8. Hukang Guo, Xiaoyi Xu, Jiaqi Li, Weilin Feng, Mengxiao Zhang, Chuanjie Fang, Liping Zhu. (2022) Chemically tailored microporous nanocomposite membranes with multi-channels for intensified solvent permeation. JOURNAL OF MEMBRANE SCIENCE, 660 (120877). [PMID:]
9. Tuo Zhao, Chuan Long, Zhiqian Wang, Hong Zhu. (2021) Multication Cross-Linked Poly(p-terphenyl isatin) Anion Exchange Membranes for Fuel Cells: Effect of Cross-Linker Length on Membrane Performance. ACS Applied Energy Materials, 4 (12): (14476–14487). [PMID:]
10. Weilin Feng, Jiaqi Li, Chuanjie Fang, Lin Zhang, Liping Zhu. (2022) Controllable thermal annealing of polyimide membranes for highly-precise organic solvent nanofiltration. JOURNAL OF MEMBRANE SCIENCE, 643 (120013). [PMID:]
11. Yongjiang Yuan, Xinming Du, Hongyu Zhang, Hui Wang, Zhe Wang. (2022) Poly (isatin biphenylene) polymer containing ferrocenium derivatives for anion exchange membrane fuel cell. JOURNAL OF MEMBRANE SCIENCE, 642 (119986). [PMID:]

References

1. Qian Wang, Lei Huang, Jiayu Guan, Linjian Sang, Jifu Zheng, Qifeng Zhang, Guorui Qin, Shenghai Li, Suobo Zhang. (2023) Side chain sulfonic acid polymers with intrinsic pores in the main chain as proton exchange membranes for fuel cells and redox flow battery. JOURNAL OF MEMBRANE SCIENCE, 687 (122036). [PMID:]
2. Hukang Guo, Fupeng Li, Xuerong Shui, Jianyu Wang, Chuanjie Fang, Liping Zhu. (2023) Ultrathin Polyamide Nanofilms with Controlled Microporosity for Enhanced Solvent Permeation. ACS Applied Materials & Interfaces, 15 (30): (37077–37085). [PMID:37479673]
3. Sisheng Fang, Hai Tang, Meng Wang, Zhaozan Xu, Nanwen Li. (2023) The antifouling and separation performance of an ultrafiltration membrane derived from a novel amphiphilic copolymer containing a crown ether. JOURNAL OF MEMBRANE SCIENCE, 676 (121620). [PMID:]
4. Jiangru Wang, Yan Yang, Qirui Shen, Dazhong Shen, Qi Kang. (2023) A smartphone-based long optical path colorimetric turntable for selective determination of malachite green and investigation the specific adsorption behavior of the imprinted cavities within molecularly imprinted polymers. MICROCHEMICAL JOURNAL, 190 (108629). [PMID:]
5. Yanqing Li, Yingwu Lin, Fang Wang, Jinghan Wang, Osami Shoji, Jiakun Xu. (2023) Construction of Biocatalysts Using the P450 Scaffold for the Synthesis of Indigo from Indole. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (3): (2395). [PMID:36768714]
6. Qian Wang, Lei Huang, Zimo Wang, Jifu Zheng, Qifeng Zhang, Guorui Qin, Shenghai Li, Suobo Zhang. (2022) High Conductive Anion Exchange Membranes from All-Carbon Twisted Intrinsic Microporous Polymers. MACROMOLECULES, 55 (23): (10713–10722). [PMID:]
7. Qing Fang, Qin Liu, Zongli Xie, Matthew R. Hill, Kaisong Zhang. (2023) Two dimensional laminar MoS2 modified PTMSP membranes with improved organic solvent nanofiltration performance. JOURNAL OF MEMBRANE SCIENCE, 666 (121139). [PMID:]
8. Hukang Guo, Xiaoyi Xu, Jiaqi Li, Weilin Feng, Mengxiao Zhang, Chuanjie Fang, Liping Zhu. (2022) Chemically tailored microporous nanocomposite membranes with multi-channels for intensified solvent permeation. JOURNAL OF MEMBRANE SCIENCE, 660 (120877). [PMID:]
9. Tuo Zhao, Chuan Long, Zhiqian Wang, Hong Zhu. (2021) Multication Cross-Linked Poly(p-terphenyl isatin) Anion Exchange Membranes for Fuel Cells: Effect of Cross-Linker Length on Membrane Performance. ACS Applied Energy Materials, 4 (12): (14476–14487). [PMID:]
10. Weilin Feng, Jiaqi Li, Chuanjie Fang, Lin Zhang, Liping Zhu. (2022) Controllable thermal annealing of polyimide membranes for highly-precise organic solvent nanofiltration. JOURNAL OF MEMBRANE SCIENCE, 643 (120013). [PMID:]
11. Yongjiang Yuan, Xinming Du, Hongyu Zhang, Hui Wang, Zhe Wang. (2022) Poly (isatin biphenylene) polymer containing ferrocenium derivatives for anion exchange membrane fuel cell. JOURNAL OF MEMBRANE SCIENCE, 642 (119986). [PMID:]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Isatin - 98%, high purity , CAS No.91-56-5