Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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I104665-25g | 25g | In stock | $31.90 | |
I104665-100g | 100g | In stock | $65.90 | |
I104665-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $223.90 |
Selective MAOB inhibitor. Potent ANP receptor antagonist
Synonyms | NSC 9262 | 3-Indolinedione | 5-21-10-00221 (Beilstein Handbook Reference) | CHEBI:27539 | Isotin | 2,3-Indolinedione | AS-10908 | UNII-82X95S7M06 | AKOS000119125 | A843979 | DTXSID3038694 | InChI=1/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11 | N |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Selective endogenous MAOB inhibitor and potent ANP receptor antagonist (IC 50 = 3-8 and 0.4 μM respectively). Inhibits alkaline phosphatase and (NO-stimulated soluble guanylate cyclase. Anxiolytic, sedative, anticonvulsant and antidiuretic effects in vivo |
Storage Temp | Desiccated |
Shipped In | Normal |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Isatin is an endogenous monoamine oxidase (MAO) inhibitor involved in stress and anxiety. Additionally, isatin inhibits alkaline phosphatase (ALP), nitric oxide (NO)-stimulated soluble guanylate cyclase, and other enzymes. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 1H-indole-2,3-dione |
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INCHI | InChI=1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11) |
InChi Key | JXDYKVIHCLTXOP-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C2C(=C1)C(=O)C(=O)N2 |
Isomeric SMILES | C1=CC=C2C(=C1)C(=O)C(=O)N2 |
WGK Germany | 1 |
RTECS | NL7873000 |
PubChem CID | 7054 |
Molecular Weight | 147.13 |
Beilstein | 383659 |
Reaxy-Rn | 383659 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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A2119237 | Certificate of Analysis | Nov 15, 2024 | I104665 |
J2014139 | Certificate of Analysis | Aug 16, 2024 | I104665 |
I2203305 | Certificate of Analysis | Jul 07, 2022 | I104665 |
I2203306 | Certificate of Analysis | Jul 07, 2022 | I104665 |
I2203307 | Certificate of Analysis | Jul 07, 2022 | I104665 |
I2203308 | Certificate of Analysis | Jul 07, 2022 | I104665 |
B2308085 | Certificate of Analysis | Oct 18, 2021 | I104665 |
B2308994 | Certificate of Analysis | Oct 18, 2021 | I104665 |
Solubility | Soluble in water (1.9 g/l at 20 °C). |
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Flash Point(°F) | 220 °C |
Flash Point(°C) | 220°C |
Melt Point(°C) | 203.5°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 1 |
RTECS | NL7873000 |
Reaxy-Rn | 383659 |
Merck Index | 5104 |
1. Qian Wang, Lei Huang, Jiayu Guan, Linjian Sang, Jifu Zheng, Qifeng Zhang, Guorui Qin, Shenghai Li, Suobo Zhang. (2023) Side chain sulfonic acid polymers with intrinsic pores in the main chain as proton exchange membranes for fuel cells and redox flow battery. JOURNAL OF MEMBRANE SCIENCE, 687 (122036). [PMID:] [10.1016/j.memsci.2023.122036] |
2. Hukang Guo, Fupeng Li, Xuerong Shui, Jianyu Wang, Chuanjie Fang, Liping Zhu. (2023) Ultrathin Polyamide Nanofilms with Controlled Microporosity for Enhanced Solvent Permeation. ACS Applied Materials & Interfaces, 15 (30): (37077–37085). [PMID:37479673] [10.1021/acsami.3c07440] |
3. Sisheng Fang, Hai Tang, Meng Wang, Zhaozan Xu, Nanwen Li. (2023) The antifouling and separation performance of an ultrafiltration membrane derived from a novel amphiphilic copolymer containing a crown ether. JOURNAL OF MEMBRANE SCIENCE, 676 (121620). [PMID:] [10.1016/j.memsci.2023.121620] |
4. Jiangru Wang, Yan Yang, Qirui Shen, Dazhong Shen, Qi Kang. (2023) A smartphone-based long optical path colorimetric turntable for selective determination of malachite green and investigation the specific adsorption behavior of the imprinted cavities within molecularly imprinted polymers. MICROCHEMICAL JOURNAL, 190 (108629). [PMID:] [10.1016/j.microc.2023.108629] |
5. Yanqing Li, Yingwu Lin, Fang Wang, Jinghan Wang, Osami Shoji, Jiakun Xu. (2023) Construction of Biocatalysts Using the P450 Scaffold for the Synthesis of Indigo from Indole. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (3): (2395). [PMID:36768714] [10.3390/ijms24032395] |
6. Qian Wang, Lei Huang, Zimo Wang, Jifu Zheng, Qifeng Zhang, Guorui Qin, Shenghai Li, Suobo Zhang. (2022) High Conductive Anion Exchange Membranes from All-Carbon Twisted Intrinsic Microporous Polymers. MACROMOLECULES, 55 (23): (10713–10722). [PMID:] [10.1021/acs.macromol.2c01874] |
7. Qing Fang, Qin Liu, Zongli Xie, Matthew R. Hill, Kaisong Zhang. (2023) Two dimensional laminar MoS2 modified PTMSP membranes with improved organic solvent nanofiltration performance. JOURNAL OF MEMBRANE SCIENCE, 666 (121139). [PMID:] [10.1016/j.memsci.2022.121139] |
8. Hukang Guo, Xiaoyi Xu, Jiaqi Li, Weilin Feng, Mengxiao Zhang, Chuanjie Fang, Liping Zhu. (2022) Chemically tailored microporous nanocomposite membranes with multi-channels for intensified solvent permeation. JOURNAL OF MEMBRANE SCIENCE, 660 (120877). [PMID:] [10.1016/j.memsci.2022.120877] |
9. Tuo Zhao, Chuan Long, Zhiqian Wang, Hong Zhu. (2021) Multication Cross-Linked Poly(p-terphenyl isatin) Anion Exchange Membranes for Fuel Cells: Effect of Cross-Linker Length on Membrane Performance. ACS Applied Energy Materials, 4 (12): (14476–14487). [PMID:] [10.1021/acsaem.1c03153] |
10. Weilin Feng, Jiaqi Li, Chuanjie Fang, Lin Zhang, Liping Zhu. (2022) Controllable thermal annealing of polyimide membranes for highly-precise organic solvent nanofiltration. JOURNAL OF MEMBRANE SCIENCE, 643 (120013). [PMID:] [10.1016/j.memsci.2021.120013] |
11. Yongjiang Yuan, Xinming Du, Hongyu Zhang, Hui Wang, Zhe Wang. (2022) Poly (isatin biphenylene) polymer containing ferrocenium derivatives for anion exchange membrane fuel cell. JOURNAL OF MEMBRANE SCIENCE, 642 (119986). [PMID:] [10.1016/j.memsci.2021.119986] |
12. Zhao Shuxue, Chen Xi, Sun Qianshu, Wang Fei, Hu Chunhui, Guo Lizhong, Bai Jie, Yu Hao. (2021) Label-Free Quantitative Proteomic Analysis of the Global Response to Indole-3-Acetic Acid in Newly Isolated Pseudomonas sp. Strain LY1. Frontiers in Microbiology, 12 (2010). [PMID:34447357] [10.3389/fmicb.2021.694874] |
13. Ziqin Li, Riming Yu, Chang Liu, Jifu Zheng, Jing Guo, Tauqir A. Sherazi, Shenghai Li, Suobo Zhang. (2021) Preparation and characterization of side-chain poly(aryl ether ketone) anion exchange membranes by superacid-catalyzed reaction. POLYMER, 222 (123639). [PMID:] [10.1016/j.polymer.2021.123639] |
14. Ziqin Li, Jing Guo, Jifu Zheng, Tauqir A. Sherazi, Shenghai Li, Suobo Zhang. (2020) A Microporous Polymer with Suspended Cations for Anion Exchange Membrane Fuel Cells. MACROMOLECULES, 53 (24): (10998–11008). [PMID:] [10.1021/acs.macromol.0c01948] |
15. Jiaqi Li, Mengxiao Zhang, Weilin Feng, Liping Zhu, Lin Zhang. (2020) PIM-1 pore-filled thin film composite membranes for tunable organic solvent nanofiltration. JOURNAL OF MEMBRANE SCIENCE, 601 (117951). [PMID:] [10.1016/j.memsci.2020.117951] |
16. Yanjuan Gao, Guoying Wang, Aijuan Zhou, Xiuping Yue, Yanqing Duan, Xin Kong, Xiao Zhang. (2019) Effect of nitrate on indole degradation characteristics and methanogenesis under mixed denitrification and methanogenesis culture. BIOCHEMICAL ENGINEERING JOURNAL, 145 (33). [PMID:] [10.1016/j.bej.2019.02.009] |
17. Chun-Er Lin, Ming-Yong Zhou, Wei-Song Hung, Bao-Ku Zhu, Kueir-Rarn Lee, Li-Ping Zhu, Li-Feng Fang. (2018) Ultrathin nanofilm with tailored pore size fabricated by metal-phenolic network for precise and rapid molecular separation. SEPARATION AND PURIFICATION TECHNOLOGY, 207 (435). [PMID:] [10.1016/j.seppur.2018.06.077] |
18. Cuiling Wang, Jiaxu Yan, Mo Du, Joseph A. Burlison, Chi Li, Yanni Sun, Danqing Zhao, Jianli Liu. (2017) One step synthesis of indirubins by reductive coupling of isatins with KBH4. TETRAHEDRON, 73 (2780). [PMID:] [10.1016/j.tet.2017.03.077] |
19. Jin-Qiang Liu, Si-Yu Chen, Baoming Ji. (2014) Solubility and Thermodynamic Functions of Isatin in Pure Solvents. JOURNAL OF CHEMICAL AND ENGINEERING DATA, 59 (11): (3407–3414). [PMID:] [10.1021/je500396b] |
20. Bin Yu, Ping-Ping Qi, Xiao-Jing Shi, Li-Hong Shan, De-Quan Yu, Hong-Min Liu. (2014) Discovery of novel steroidal pyran–oxindole hybrids as cytotoxic agents. STEROIDS, 88 (44). [PMID:24928731] [10.1016/j.steroids.2014.05.022] |
1. Qian Wang, Lei Huang, Jiayu Guan, Linjian Sang, Jifu Zheng, Qifeng Zhang, Guorui Qin, Shenghai Li, Suobo Zhang. (2023) Side chain sulfonic acid polymers with intrinsic pores in the main chain as proton exchange membranes for fuel cells and redox flow battery. JOURNAL OF MEMBRANE SCIENCE, 687 (122036). [PMID:] [10.1016/j.memsci.2023.122036] |
2. Hukang Guo, Fupeng Li, Xuerong Shui, Jianyu Wang, Chuanjie Fang, Liping Zhu. (2023) Ultrathin Polyamide Nanofilms with Controlled Microporosity for Enhanced Solvent Permeation. ACS Applied Materials & Interfaces, 15 (30): (37077–37085). [PMID:37479673] [10.1021/acsami.3c07440] |
3. Sisheng Fang, Hai Tang, Meng Wang, Zhaozan Xu, Nanwen Li. (2023) The antifouling and separation performance of an ultrafiltration membrane derived from a novel amphiphilic copolymer containing a crown ether. JOURNAL OF MEMBRANE SCIENCE, 676 (121620). [PMID:] [10.1016/j.memsci.2023.121620] |
4. Jiangru Wang, Yan Yang, Qirui Shen, Dazhong Shen, Qi Kang. (2023) A smartphone-based long optical path colorimetric turntable for selective determination of malachite green and investigation the specific adsorption behavior of the imprinted cavities within molecularly imprinted polymers. MICROCHEMICAL JOURNAL, 190 (108629). [PMID:] [10.1016/j.microc.2023.108629] |
5. Yanqing Li, Yingwu Lin, Fang Wang, Jinghan Wang, Osami Shoji, Jiakun Xu. (2023) Construction of Biocatalysts Using the P450 Scaffold for the Synthesis of Indigo from Indole. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (3): (2395). [PMID:36768714] [10.3390/ijms24032395] |
6. Qian Wang, Lei Huang, Zimo Wang, Jifu Zheng, Qifeng Zhang, Guorui Qin, Shenghai Li, Suobo Zhang. (2022) High Conductive Anion Exchange Membranes from All-Carbon Twisted Intrinsic Microporous Polymers. MACROMOLECULES, 55 (23): (10713–10722). [PMID:] [10.1021/acs.macromol.2c01874] |
7. Qing Fang, Qin Liu, Zongli Xie, Matthew R. Hill, Kaisong Zhang. (2023) Two dimensional laminar MoS2 modified PTMSP membranes with improved organic solvent nanofiltration performance. JOURNAL OF MEMBRANE SCIENCE, 666 (121139). [PMID:] [10.1016/j.memsci.2022.121139] |
8. Hukang Guo, Xiaoyi Xu, Jiaqi Li, Weilin Feng, Mengxiao Zhang, Chuanjie Fang, Liping Zhu. (2022) Chemically tailored microporous nanocomposite membranes with multi-channels for intensified solvent permeation. JOURNAL OF MEMBRANE SCIENCE, 660 (120877). [PMID:] [10.1016/j.memsci.2022.120877] |
9. Tuo Zhao, Chuan Long, Zhiqian Wang, Hong Zhu. (2021) Multication Cross-Linked Poly(p-terphenyl isatin) Anion Exchange Membranes for Fuel Cells: Effect of Cross-Linker Length on Membrane Performance. ACS Applied Energy Materials, 4 (12): (14476–14487). [PMID:] [10.1021/acsaem.1c03153] |
10. Weilin Feng, Jiaqi Li, Chuanjie Fang, Lin Zhang, Liping Zhu. (2022) Controllable thermal annealing of polyimide membranes for highly-precise organic solvent nanofiltration. JOURNAL OF MEMBRANE SCIENCE, 643 (120013). [PMID:] [10.1016/j.memsci.2021.120013] |
11. Yongjiang Yuan, Xinming Du, Hongyu Zhang, Hui Wang, Zhe Wang. (2022) Poly (isatin biphenylene) polymer containing ferrocenium derivatives for anion exchange membrane fuel cell. JOURNAL OF MEMBRANE SCIENCE, 642 (119986). [PMID:] [10.1016/j.memsci.2021.119986] |
12. Zhao Shuxue, Chen Xi, Sun Qianshu, Wang Fei, Hu Chunhui, Guo Lizhong, Bai Jie, Yu Hao. (2021) Label-Free Quantitative Proteomic Analysis of the Global Response to Indole-3-Acetic Acid in Newly Isolated Pseudomonas sp. Strain LY1. Frontiers in Microbiology, 12 (2010). [PMID:34447357] [10.3389/fmicb.2021.694874] |
13. Ziqin Li, Riming Yu, Chang Liu, Jifu Zheng, Jing Guo, Tauqir A. Sherazi, Shenghai Li, Suobo Zhang. (2021) Preparation and characterization of side-chain poly(aryl ether ketone) anion exchange membranes by superacid-catalyzed reaction. POLYMER, 222 (123639). [PMID:] [10.1016/j.polymer.2021.123639] |
14. Ziqin Li, Jing Guo, Jifu Zheng, Tauqir A. Sherazi, Shenghai Li, Suobo Zhang. (2020) A Microporous Polymer with Suspended Cations for Anion Exchange Membrane Fuel Cells. MACROMOLECULES, 53 (24): (10998–11008). [PMID:] [10.1021/acs.macromol.0c01948] |
15. Jiaqi Li, Mengxiao Zhang, Weilin Feng, Liping Zhu, Lin Zhang. (2020) PIM-1 pore-filled thin film composite membranes for tunable organic solvent nanofiltration. JOURNAL OF MEMBRANE SCIENCE, 601 (117951). [PMID:] [10.1016/j.memsci.2020.117951] |
16. Yanjuan Gao, Guoying Wang, Aijuan Zhou, Xiuping Yue, Yanqing Duan, Xin Kong, Xiao Zhang. (2019) Effect of nitrate on indole degradation characteristics and methanogenesis under mixed denitrification and methanogenesis culture. BIOCHEMICAL ENGINEERING JOURNAL, 145 (33). [PMID:] [10.1016/j.bej.2019.02.009] |
17. Chun-Er Lin, Ming-Yong Zhou, Wei-Song Hung, Bao-Ku Zhu, Kueir-Rarn Lee, Li-Ping Zhu, Li-Feng Fang. (2018) Ultrathin nanofilm with tailored pore size fabricated by metal-phenolic network for precise and rapid molecular separation. SEPARATION AND PURIFICATION TECHNOLOGY, 207 (435). [PMID:] [10.1016/j.seppur.2018.06.077] |
18. Cuiling Wang, Jiaxu Yan, Mo Du, Joseph A. Burlison, Chi Li, Yanni Sun, Danqing Zhao, Jianli Liu. (2017) One step synthesis of indirubins by reductive coupling of isatins with KBH4. TETRAHEDRON, 73 (2780). [PMID:] [10.1016/j.tet.2017.03.077] |
19. Jin-Qiang Liu, Si-Yu Chen, Baoming Ji. (2014) Solubility and Thermodynamic Functions of Isatin in Pure Solvents. JOURNAL OF CHEMICAL AND ENGINEERING DATA, 59 (11): (3407–3414). [PMID:] [10.1021/je500396b] |
20. Bin Yu, Ping-Ping Qi, Xiao-Jing Shi, Li-Hong Shan, De-Quan Yu, Hong-Min Liu. (2014) Discovery of novel steroidal pyran–oxindole hybrids as cytotoxic agents. STEROIDS, 88 (44). [PMID:24928731] [10.1016/j.steroids.2014.05.022] |