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Isavuconazole - 98%, high purity , CAS No.241479-67-4

≥98%

CAS#: 241479-67-4
Formula: C₂₂H₁₇F₂N₅OS
Molecular Weight: 437.47
PubChem CID: 6918485

Item Number

I337027

Grouped product items
SKU	Size	Availability	Price
I337027-100mg	100mg	In stock	$687.90
I337027-250mg	250mg	In stock	$1,374.90
I337027-1g	1g	In stock	$3,434.90

a broad-spectrum antifungal

Basic Description

Synonyms	Isavuconazole\|241479-67-4\|BAL-4815\|isavuconazol\|BAL 4815\|Isavuconazole [INN]\|isavuconazolum\|1286730-05-9\|CHEBI:85979\|UNII-60UTO373KE\|60UTO373KE\|RO 0094815\|4-[2-[(1R,2R)-2-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Isavuconazole is a triazole antifungal drug. It inhibits fungal sterol biosynthesis by inhibition of cytochrome P450 sterol 14-α-demethylase (CYP51), an enzyme in the sterol biosynthesis pathway that leads from lanosterol to ergosterol. It has been approv
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Isavuconazole is an extended-spectrum triazole with activity against a wide variety of fungal pathogens. Isavuconazole has shown activity against the dimorphic true pathogenic fungi, such as\|Blastomyces dermatitidis\|and\|Histoplasma capsulatum\|, and is also active against uncommon dematiaceous fungi such as\|Exophiala spp.\|and\|Phialophora spp.\|as well as against dermatophytic species. Isavuconazole showed broad spectrum antifungal activity against FLC-resistant strains of\|Candida spp.\|,\|Aspergillus spp.\|and uncommon opportunistic fungal species.

Associated Targets

CYP2B6 Tchem Cytochrome P450 2B6 0 Activities

Discover Target: CYP2B6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCG2 Tchem ATP-binding cassette sub-family G member 2 0 Activities

Discover Target: ABCG2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[2-[(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile
INCHI	InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-8-17(23)6-7-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1
InChi Key	DDFOUSQFMYRUQK-RCDICMHDSA-N
Canonical SMILES	CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(CN3C=NC=N3)(C4=C(C=CC(=C4)F)F)O
Isomeric SMILES	C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=NC=N3)(C4=C(C=CC(=C4)F)F)O
PubChem CID	6918485
Molecular Weight	437.47

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
A2426072	Certificate of Analysis	Jul 20, 2022	I337027
I2222734	Certificate of Analysis	Jul 20, 2022	I337027
I2222741	Certificate of Analysis	Jul 20, 2022	I337027
I2222906	Certificate of Analysis	Jul 20, 2022	I337027

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Warning
Hazard Statements	H361fd:Suspected of damaging fertility; Suspected of damaging the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P201:Obtain special instructions before use. P308+P313:IF exposed or concerned: Get medical advice/attention. P202:Do not handle until all safety precautions have been read and understood.

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