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I422805-1ml

1ml

Available within 4-8 weeks(?)

$234.90

Basic Description

Synonyms	Isavuconazole \| 241479-67-4 \| BAL-4815 \| isavuconazol \| BAL 4815 \| Isavuconazole [INN] \| isavuconazolum \| 1286730-05-9 \| CHEBI:85979 \| UNII-60UTO373KE \| 60UTO373KE \| RO 0094815 \| 4-[2-[(1R,2R)-2-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl
Specifications & Purity	10mM in DMSO
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Isavuconazole is an extended-spectrum triazole with activity against a wide variety of fungal pathogens. Isavuconazole has shown activity against the dimorphic true pathogenic fungi, such as\|Blastomyces dermatitidis\|and\|Histoplasma capsulatum\|, and is also active against uncommon dematiaceous fungi such as\|Exophiala spp.\|and\|Phialophora spp.\|as well as against dermatophytic species. Isavuconazole showed broad spectrum antifungal activity against FLC-resistant strains of\|Candida spp.\|,\|Aspergillus spp.\|and uncommon opportunistic fungal species.

Associated Targets(Human)

CYP2B6 Tchem Cytochrome P450 2B6 (1338 Activities)

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ABCG2 Tchem ATP-binding cassette sub-family G member 2 (4927 Activities)

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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

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Naganishia albida (59 Activities)

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Aspergillus flavus (8875 Activities)

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Aspergillus niger (16508 Activities)

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Mucor (407 Activities)

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Rhizopus (548 Activities)

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Saccharomyces cerevisiae (19171 Activities)

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Aspergillus sp. (177 Activities)

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Pichia kudriavzevii (7448 Activities)

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Aspergillus fumigatus (16427 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida (1648 Activities)

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Candida albicans (78123 Activities)

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Nakaseomyces glabratus (9108 Activities)

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Candida parapsilosis (8521 Activities)

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Candida tropicalis (8381 Activities)

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Rhodotorula mucilaginosa (339 Activities)

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Mus musculus (284745 Activities)

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Fonsecaea pedrosoi (116 Activities)

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Lomentospora prolificans (67 Activities)

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Aspergillus terreus (892 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Absidia (79 Activities)

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Cunninghamella (93 Activities)

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Magnusiomyces capitatus (133 Activities)

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Fusarium (166 Activities)

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Rhizomucor (96 Activities)

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Syncephalastrum (30 Activities)

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Trichosporon (49 Activities)

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Trichosporon asahii (679 Activities)

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Trichosporon inkin (55 Activities)

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Cutaneotrichosporon mucoides (51 Activities)

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Plasma (328 Activities)

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Cryptococcus bacillisporus (1003 Activities)

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Scedosporium apiospermum (112 Activities)

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Fonsecaea monophora (64 Activities)

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SARS-CoV-2 (38078 Activities)

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Names and Identifiers

IUPAC Name	4-[2-[(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile
INCHI	InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-8-17(23)6-7-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1
InChi Key	DDFOUSQFMYRUQK-RCDICMHDSA-N
Canonical SMILES	CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(CN3C=NC=N3)(C4=C(C=CC(=C4)F)F)O
Isomeric SMILES	C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=NC=N3)(C4=C(C=CC(=C4)F)F)O
PubChem CID	6918485
Molecular Weight	437.47

Certificates

Certificate of Analysis(COA)

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Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Warning
Hazard Statements	H361fd:Suspected of damaging fertility; Suspected of damaging the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P201:Obtain special instructions before use. P308+P313:IF exposed or concerned: Get medical advice/attention. P202:Do not handle until all safety precautions have been read and understood.

Citations of This Product

1. Wenjing Li, Yang Li, Junlong Cai, Yue Wang, Yanan Liu, Hankun Hu, Liang Liu. (2023) Simultaneous Quantification of Seven Antifungal Agents in Human Serum Using Liquid Chromatography-Tandem Mass Spectrometry. Pharmaceuticals, 16 (11): (1537). [PMID:38004403]
2. Mengming Xia, Xueyi Song, Zebei Lu, Yu Wang, Quan Zhou, Peiwu Geng, Shuanghu Wang, Yunfang Zhou, Qingjun Wu, Aixia Han. (2023) Evaluation of the inhibitory effect of azoles on pharmacokinetics of lenvatinib in rats both in vivo and in vitro by UPLC-MS/MS. Thoracic Cancer, 14 (33): (3331-3341). [PMID:37771131]

References

1. Wenjing Li, Yang Li, Junlong Cai, Yue Wang, Yanan Liu, Hankun Hu, Liang Liu. (2023) Simultaneous Quantification of Seven Antifungal Agents in Human Serum Using Liquid Chromatography-Tandem Mass Spectrometry. Pharmaceuticals, 16 (11): (1537). [PMID:38004403]
2. Mengming Xia, Xueyi Song, Zebei Lu, Yu Wang, Quan Zhou, Peiwu Geng, Shuanghu Wang, Yunfang Zhou, Qingjun Wu, Aixia Han. (2023) Evaluation of the inhibitory effect of azoles on pharmacokinetics of lenvatinib in rats both in vivo and in vitro by UPLC-MS/MS. Thoracic Cancer, 14 (33): (3331-3341). [PMID:37771131]

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Isavuconazole - 10mM in DMSO, high purity , CAS No.241479-67-4

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator