Purity≥95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab175491-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $89.90 | |
| Ab175491-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $449.90 | |
| Ab175491-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,399.90 | |
| Ab175491-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,239.90 |
Purity≥95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Iscalimab (anti-CD40) - Primary antibody, specific to CD40, Human IgG1 |
|---|---|
| Synonyms | CFZ-533;iscalimab (proposed INN);NVP-CFZ533;OM11-62MF |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC) |
| Specificity | CD40 |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | Antibody of CD40 |
| Product Description |
Iscalimab (anti-CD40) is a non-depleting IGg1 monoclonal antibody targeting CD40 (KD: 0.3 nM). Iscalimab (anti-CD40) can be used for research of Graves' hyperthyroidism and autoimmune diseases. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 27.2 kDa (Light Chain) & 52.2 kDa (Heavy Chain), under reducing conditions; 201.2 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Form | Liquid |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 2031153-61-2 |
Iscalimab (anti-CD40) (Ab175491) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD40 with Iscalimab (anti-CD40) (Ab175491) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).
Iscalimab (anti-CD40) (Ab175491) - ELISA
Immobilized Recombinant Human CD40 protein (rp183577) at 1.0 μg/mL can bind Iscalimab (anti-CD40) (Ab175491) with the EC₅₀ of 35.88 ng/mL.
Iscalimab (anti-CD40) (Ab175491) - SEC
The purity of Iscalimab (anti-CD40) (Ab175491) is more than 95% verified by HPLC.
Iscalimab (anti-CD40) (Ab175491) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD40 (red) with Iscalimab (anti-CD40) (Ab175491). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Iscalimab (anti-CD40) (Ab175491) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD40 (red) with Iscalimab (anti-CD40) (Ab175491) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| IMGT/mAb-DB | 799 |
|---|
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0708725 | Certificate of Analysis | Jul 24, 2024 | Ab175491 |
| ZJ24F0708644 | Certificate of Analysis | Jul 24, 2024 | Ab175491 |
| ZJ24F0708643 | Certificate of Analysis | Jul 24, 2024 | Ab175491 |
