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Isobavachalcone - 10mM in DMSO, high purity , CAS No.20784-50-3
1 Citations
Akt inhibitor. Natural chalcone.
Basic Description
| Synonyms | Isobavachalcone | 20784-50-3 | Corylifolinin | Isobacachalcone | 4-Hydroxyisocordoin | ZWO2SC993A | CHEBI:28106 | 2',4,4'-Trihydroxy-3'-(3-methyl-2-butenyl)chalcone | UNII-ZWO2SC993A | Corylifolinin;Isobacachalcone | (E)-1-(2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-3-(4 |
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| Specifications & Purity | 10mM in DMSO |
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| Biochemical and Physiological Mechanisms | Isobavachalcone inhibits platelet aggregation. Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Isobavachalcone exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) |
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| Storage Temp | Store at -80°C |
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| Shipped In | Ice chest + Ice pads |
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| Product Description | Isobavachalcone(Corylifolinin) is a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma.
An inhibitor of platelet aggregation |
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Associated Targets(Human)
Associated Targets(non-human)
Names and Identifiers
| IUPAC Name | (E)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one |
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| INCHI | InChI=1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+ |
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| InChi Key | DUWPGRAKHMEPCM-IZZDOVSWSA-N |
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| Canonical SMILES | CC(=CCC1=C(C=CC(=C1O)C(=O)C=CC2=CC=C(C=C2)O)O)C |
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| Isomeric SMILES | CC(=CCC1=C(C=CC(=C1O)C(=O)/C=C/C2=CC=C(C=C2)O)O)C |
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| PubChem CID | 5281255 |
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| Molecular Weight | 324.38 |
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Chemical and Physical Properties
| Refractive Index | 1.66 |
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| Boil Point(°C) | ~549.03° C at 760 mmHg |
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| Melt Point(°C) | 210.09°C |
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Citations of This Product
| 1. Wu Yueshan, Chang Jing, Ge Juanjuan, Xu Kangyan, Zhou Quan, Zhang Xiaowen, Zhu Ni, Hu Meichun. (2022) Isobavachalcone’s Alleviation of Pyroptosis Contributes to Enhanced Apoptosis in Glioblastoma: Possible Involvement of NLRP3. MOLECULAR NEUROBIOLOGY, 59 (11): (6934-6955). [PMID:36053436] |
References
| 1. Wu Yueshan, Chang Jing, Ge Juanjuan, Xu Kangyan, Zhou Quan, Zhang Xiaowen, Zhu Ni, Hu Meichun. (2022) Isobavachalcone’s Alleviation of Pyroptosis Contributes to Enhanced Apoptosis in Glioblastoma: Possible Involvement of NLRP3. MOLECULAR NEUROBIOLOGY, 59 (11): (6934-6955). [PMID:36053436] |
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