Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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I111283-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $169.90 | |
I111283-20mg | 20mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $269.90 |
Antioxidant and antiangiogenic agent
Synonyms | isoliquiritigenin | 961-29-5 | 2',4,4'-Trihydroxychalcone | (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one | 4,2',4'-Trihydroxychalcone | 6'-deoxychalcone | Isoliquiritigen | GU 17 | 2',4',4-Trihydroxychalcone | Chalcone, 2',4,4'-trihydroxy- | GU-17 | C15H12O4 | |
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Specifications & Purity | analytical standard |
Biochemical and Physiological Mechanisms | Antioxidant and antiangiogenic agent. Reduces NO release from LPS-stimulated macrophages. Inhibits VEGF-induced proliferation. Inhibits neoangiogenesis. Suppresses VEGF/VEGFR-2 signaling. Shows cardioprotective, anti-ischemic effects in vivo. |
Storage Temp | Store at 2-8°C,Protected from light,Desiccated |
Shipped In | Wet ice |
Grade | analytical standard |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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IUPAC Name | (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one |
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INCHI | InChI=1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+ |
InChi Key | DXDRHHKMWQZJHT-FPYGCLRLSA-N |
Canonical SMILES | C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O |
Isomeric SMILES | C1=CC(=CC=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O |
WGK Germany | 3 |
RTECS | FL7080000 |
PubChem CID | 638278 |
Molecular Weight | 256.25 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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D2425003 | Certificate of Analysis | May 10, 2024 | I111283 |
C1729013 | Certificate of Analysis | Sep 21, 2022 | I111283 |
B2216157 | Certificate of Analysis | Feb 19, 2022 | I111283 |
Sensitivity | Hygroscopic. |
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Melt Point(°C) | 198 °C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | FL7080000 |
1. Liangwan Wei, Zhe Wang, Yindi Chu, Kun Cai, Wei Li, Piying Huang, Youcai Qin, Dailin Liu, Xiaocui Zhuang, Mingquan Guo, Xinbo Song, Enguo Fan. (2023) Licochalcone A inhibits the assembly function of β-barrel assembly machinery in Escherichia coli. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 668 (90). [PMID:37245294] |
2. Zhang Xiuying, Chen Qilei, Zhao Jia, Zhao Wei, Fan Ni, Wang Yu, Chen Hubiao, Rong Jianhui. (2023) A four-compound remedy AGILe protected H9c2 cardiomyocytes against oxygen glucose deprivation via targeting the TNF-α/NF-κB pathway: Implications for the therapy of myocardial infarction. Frontiers in Pharmacology, 14 [PMID:36713834] |
3. Yufang Su, Lei Fang, Kaili Zhong, Ting Wang, Mingjie Bao, Ting Zhou, Yuan Zhu. (2023) Isoliquiritigenin induces oxidative stress and immune response in zebrafish embryos. ENVIRONMENTAL TOXICOLOGY, 38 (3): (654-665). [PMID:36617718] |
4. Jianman Wang, Hongjin Chen, Tao Guo, Ping Yue, Tianbao Qian, Xiangyu Zeng, Yali Luo, Jiangmin Li, Lijing Teng, Qingyu Liu, Liang Hong, Zijiang Yu, Zuquan Hu. (2022) Isoliquiritigenin Nanoemulsion Preparation by Combined Sonication and Phase-Inversion Composition Method: In Vitro Anticancer Activities. Bioengineering-Basel, 9 (8): (382). [PMID:36004907] |
1. Liangwan Wei, Zhe Wang, Yindi Chu, Kun Cai, Wei Li, Piying Huang, Youcai Qin, Dailin Liu, Xiaocui Zhuang, Mingquan Guo, Xinbo Song, Enguo Fan. (2023) Licochalcone A inhibits the assembly function of β-barrel assembly machinery in Escherichia coli. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 668 (90). [PMID:37245294] |
2. Zhang Xiuying, Chen Qilei, Zhao Jia, Zhao Wei, Fan Ni, Wang Yu, Chen Hubiao, Rong Jianhui. (2023) A four-compound remedy AGILe protected H9c2 cardiomyocytes against oxygen glucose deprivation via targeting the TNF-α/NF-κB pathway: Implications for the therapy of myocardial infarction. Frontiers in Pharmacology, 14 [PMID:36713834] |
3. Yufang Su, Lei Fang, Kaili Zhong, Ting Wang, Mingjie Bao, Ting Zhou, Yuan Zhu. (2023) Isoliquiritigenin induces oxidative stress and immune response in zebrafish embryos. ENVIRONMENTAL TOXICOLOGY, 38 (3): (654-665). [PMID:36617718] |
4. Jianman Wang, Hongjin Chen, Tao Guo, Ping Yue, Tianbao Qian, Xiangyu Zeng, Yali Luo, Jiangmin Li, Lijing Teng, Qingyu Liu, Liang Hong, Zijiang Yu, Zuquan Hu. (2022) Isoliquiritigenin Nanoemulsion Preparation by Combined Sonication and Phase-Inversion Composition Method: In Vitro Anticancer Activities. Bioengineering-Basel, 9 (8): (382). [PMID:36004907] |