Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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I111284-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $22.90 | |
I111284-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $45.90 | |
I111284-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $165.90 | |
I111284-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $620.90 | |
I111284-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $2,235.90 |
Synonyms | SMR000112969 | EU-0100681 | NCGC00261366-01 | SR-01000075499 | (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one | A845551 | CHEBI:94010 | Isoliquiritigenin, powder | 2'',4'',4-trihydroxychalcone | 2'',4,4''-trihydroxychalcone | 2',4',4-Trihy |
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Specifications & Purity | ≥98% |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one |
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INCHI | InChI=1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+ |
InChi Key | DXDRHHKMWQZJHT-FPYGCLRLSA-N |
Canonical SMILES | C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O |
Isomeric SMILES | C1=CC(=CC=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O |
WGK Germany | 3 |
RTECS | FL7080000 |
PubChem CID | 638278 |
Molecular Weight | 256.25 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
I2420620 | Certificate of Analysis | Sep 03, 2024 | I111284 |
I2420621 | Certificate of Analysis | Sep 03, 2024 | I111284 |
I2420622 | Certificate of Analysis | Sep 03, 2024 | I111284 |
I2420623 | Certificate of Analysis | Sep 03, 2024 | I111284 |
I2420624 | Certificate of Analysis | Sep 03, 2024 | I111284 |
G2213594 | Certificate of Analysis | Jul 19, 2022 | I111284 |
G2404020 | Certificate of Analysis | Jul 19, 2022 | I111284 |
H2205100 | Certificate of Analysis | Jun 09, 2022 | I111284 |
H2205102 | Certificate of Analysis | Jun 09, 2022 | I111284 |
H2205103 | Certificate of Analysis | Jun 09, 2022 | I111284 |
H2205104 | Certificate of Analysis | Jun 09, 2022 | I111284 |
L2315070 | Certificate of Analysis | Jun 09, 2022 | I111284 |
Sensitivity | Heat & Air sensitive,Hygroscopic |
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Melt Point(°C) | 198 °C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | FL7080000 |
1. Liangwan Wei, Zhe Wang, Yindi Chu, Kun Cai, Wei Li, Piying Huang, Youcai Qin, Dailin Liu, Xiaocui Zhuang, Mingquan Guo, Xinbo Song, Enguo Fan. (2023) Licochalcone A inhibits the assembly function of β-barrel assembly machinery in Escherichia coli. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 668 (90). [PMID:37245294] [10.1016/j.bbrc.2023.05.083] |
2. Zhang Xiuying, Chen Qilei, Zhao Jia, Zhao Wei, Fan Ni, Wang Yu, Chen Hubiao, Rong Jianhui. (2023) A four-compound remedy AGILe protected H9c2 cardiomyocytes against oxygen glucose deprivation via targeting the TNF-α/NF-κB pathway: Implications for the therapy of myocardial infarction. Frontiers in Pharmacology, 14 [PMID:36713834] [10.3389/fphar.2023.1050970] |
3. Yufang Su, Lei Fang, Kaili Zhong, Ting Wang, Mingjie Bao, Ting Zhou, Yuan Zhu. (2023) Isoliquiritigenin induces oxidative stress and immune response in zebrafish embryos. ENVIRONMENTAL TOXICOLOGY, 38 (3): (654-665). [PMID:36617718] [10.1002/tox.23715] |
4. Jianman Wang, Hongjin Chen, Tao Guo, Ping Yue, Tianbao Qian, Xiangyu Zeng, Yali Luo, Jiangmin Li, Lijing Teng, Qingyu Liu, Liang Hong, Zijiang Yu, Zuquan Hu. (2022) Isoliquiritigenin Nanoemulsion Preparation by Combined Sonication and Phase-Inversion Composition Method: In Vitro Anticancer Activities. Bioengineering-Basel, 9 (8): (382). [PMID:36004907] [10.3390/bioengineering9080382] |
5. Xiangrong Li, Hongyi Liu, Zhenhua Yang, Hanxiao Duan, Ziyang Wang, Zeqing Cheng, Zhizhi Song, Xinzhe Wu. (2021) Study on the interaction of hyaluronidase with certain flavonoids. JOURNAL OF MOLECULAR STRUCTURE, 1241 (130686). [PMID:] [10.1016/j.molstruc.2021.130686] |
6. Li-Juan Wang, Lin He, Lu Hao, Hong-Lei Guo, Xiang-Peng Zeng, Ya-Wei Bi, Guo-Tao Lu, Zhao-Shen Li, Liang-Hao Hu. (2020) Isoliquiritigenin ameliorates caerulein-induced chronic pancreatitis by inhibiting the activation of PSCs and pancreatic infiltration of macrophages. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 24 (17): (9667-9681). [PMID:32678498] [10.1111/jcmm.15498] |
7. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu. (2019) Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods, 8 (9): (355). [PMID:31438605] [10.3390/foods8090355] |
8. Zhang Man, Wu Yan-Qing, Xie Ling, Wu Jiang, Xu Ke, Xiao Jian, Chen Da-Qing. (2018) Isoliquiritigenin Protects Against Pancreatic Injury and Intestinal Dysfunction After Severe Acute Pancreatitis via Nrf2 Signaling. Frontiers in Pharmacology, 9 (936). [PMID:30174606] [10.3389/fphar.2018.00936] |
9. Shupeng Zhao, Haigang Chang, Pengju Ma, Guojun Gao, Cailing Jin, Xinli Zhao, Wenke Zhou, Baozhe Jin. (2015) Inhibitory effect of DNA topoisomerase inhibitor isoliquiritigenin on the growth of glioma cells. International Journal of Clinical and Experimental Pathology, 8 (10): ( 12577–12582). [PMID:26722447] [PMID:26722447] |
10. Jie-hua Shi, Jing Wang, Ying-yao Zhu, Jun Chen. (2014) Characterization of interaction between isoliquiritigenin and bovine serum albumin: Spectroscopic and molecular docking methods. JOURNAL OF LUMINESCENCE, 145 (643). [PMID:] [10.1016/j.jlumin.2013.08.042] |
1. Liangwan Wei, Zhe Wang, Yindi Chu, Kun Cai, Wei Li, Piying Huang, Youcai Qin, Dailin Liu, Xiaocui Zhuang, Mingquan Guo, Xinbo Song, Enguo Fan. (2023) Licochalcone A inhibits the assembly function of β-barrel assembly machinery in Escherichia coli. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 668 (90). [PMID:37245294] [10.1016/j.bbrc.2023.05.083] |
2. Zhang Xiuying, Chen Qilei, Zhao Jia, Zhao Wei, Fan Ni, Wang Yu, Chen Hubiao, Rong Jianhui. (2023) A four-compound remedy AGILe protected H9c2 cardiomyocytes against oxygen glucose deprivation via targeting the TNF-α/NF-κB pathway: Implications for the therapy of myocardial infarction. Frontiers in Pharmacology, 14 [PMID:36713834] [10.3389/fphar.2023.1050970] |
3. Yufang Su, Lei Fang, Kaili Zhong, Ting Wang, Mingjie Bao, Ting Zhou, Yuan Zhu. (2023) Isoliquiritigenin induces oxidative stress and immune response in zebrafish embryos. ENVIRONMENTAL TOXICOLOGY, 38 (3): (654-665). [PMID:36617718] [10.1002/tox.23715] |
4. Jianman Wang, Hongjin Chen, Tao Guo, Ping Yue, Tianbao Qian, Xiangyu Zeng, Yali Luo, Jiangmin Li, Lijing Teng, Qingyu Liu, Liang Hong, Zijiang Yu, Zuquan Hu. (2022) Isoliquiritigenin Nanoemulsion Preparation by Combined Sonication and Phase-Inversion Composition Method: In Vitro Anticancer Activities. Bioengineering-Basel, 9 (8): (382). [PMID:36004907] [10.3390/bioengineering9080382] |
5. Xiangrong Li, Hongyi Liu, Zhenhua Yang, Hanxiao Duan, Ziyang Wang, Zeqing Cheng, Zhizhi Song, Xinzhe Wu. (2021) Study on the interaction of hyaluronidase with certain flavonoids. JOURNAL OF MOLECULAR STRUCTURE, 1241 (130686). [PMID:] [10.1016/j.molstruc.2021.130686] |
6. Li-Juan Wang, Lin He, Lu Hao, Hong-Lei Guo, Xiang-Peng Zeng, Ya-Wei Bi, Guo-Tao Lu, Zhao-Shen Li, Liang-Hao Hu. (2020) Isoliquiritigenin ameliorates caerulein-induced chronic pancreatitis by inhibiting the activation of PSCs and pancreatic infiltration of macrophages. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 24 (17): (9667-9681). [PMID:32678498] [10.1111/jcmm.15498] |
7. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu. (2019) Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods, 8 (9): (355). [PMID:31438605] [10.3390/foods8090355] |
8. Zhang Man, Wu Yan-Qing, Xie Ling, Wu Jiang, Xu Ke, Xiao Jian, Chen Da-Qing. (2018) Isoliquiritigenin Protects Against Pancreatic Injury and Intestinal Dysfunction After Severe Acute Pancreatitis via Nrf2 Signaling. Frontiers in Pharmacology, 9 (936). [PMID:30174606] [10.3389/fphar.2018.00936] |
9. Shupeng Zhao, Haigang Chang, Pengju Ma, Guojun Gao, Cailing Jin, Xinli Zhao, Wenke Zhou, Baozhe Jin. (2015) Inhibitory effect of DNA topoisomerase inhibitor isoliquiritigenin on the growth of glioma cells. International Journal of Clinical and Experimental Pathology, 8 (10): ( 12577–12582). [PMID:26722447] [PMID:26722447] |
10. Jie-hua Shi, Jing Wang, Ying-yao Zhu, Jun Chen. (2014) Characterization of interaction between isoliquiritigenin and bovine serum albumin: Spectroscopic and molecular docking methods. JOURNAL OF LUMINESCENCE, 145 (643). [PMID:] [10.1016/j.jlumin.2013.08.042] |