Isonipecotic acid - 98%, high purity , CAS No.498-94-2, Agonist of GABA A receptor α1 subunit;Agonist of GABA A receptor α2 subunit;Agonist of GABA A receptor α3 subunit;Agonist of GABA A receptor α4 subunit;Agonist of GABA A receptor α5 subunit;Agonist of GABA A receptor α6 subunit;Antagonist of GABA A recept

Item Number
I109586
Grouped product items
SKUSizeAvailabilityPrice Qty
I109586-10g
10g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$15.90
I109586-100g
100g
In stock
$45.90
I109586-250g
250g
In stock
$102.90
I109586-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$133.90

Basic Description

SynonymsAcide piperidine-carboxylique-4 | EINECS 207-872-3 | Isonipecotic acid | iso-nipecotic acid | NCGC00015573-03 | SR-01000075617-1 | EN300-19594 | Acide isonipecotique | NCGC00015573-05 | s5612 | 4-Piperidinecarboxylic acid | SDCCGSBI-0050683.P002 | HY-Y117
Specifications & PurityMoligand™, ≥98%
Storage TempProtected from light
Shipped InNormal
GradeMoligand™
Action TypeAGONIST, ANTAGONIST
Mechanism of actionAgonist of GABA A receptor α1 subunit;Agonist of GABA A receptor α2 subunit;Agonist of GABA A receptor α3 subunit;Agonist of GABA A receptor α4 subunit;Agonist of GABA A receptor α5 subunit;Agonist of GABA A receptor α6 subunit;Antagonist of GABA A recept
Note5g、25g卖完停产,不再备货
Product Description

Isonipecotic acid is an important reactant for the synthesis of alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors. It is also used in the synthesis of antibiotic nitroxoline derivatives for cathepsin B inhibition.
A HDAC inhibitor.

Associated Targets(Human)

GABRR1 Tchem Gamma-aminobutyric acid receptor subunit rho-1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GABRR3 Tbio Gamma-aminobutyric acid receptor subunit rho-3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GABRA3 Tclin Gamma-aminobutyric acid receptor subunit alpha-3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GABRA4 Tclin Gamma-aminobutyric acid receptor subunit alpha-4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GABRA5 Tclin Gamma-aminobutyric acid receptor subunit alpha-5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GABRR2 Tchem Gamma-aminobutyric acid receptor subunit rho-2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GABRA2 Tclin Gamma-aminobutyric acid receptor subunit alpha-2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GABRA6 Tclin Gamma-aminobutyric acid receptor subunit alpha-6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRR1 Tchem GABA receptor rho-1 subunit (233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRG2 Tclin GABA-A receptor; alpha-3/beta-3/gamma-2 (1250 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA-A receptor; alpha-1/beta-3/gamma-2 (1565 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRG2 Tclin GABA-A receptor; alpha-5/beta-3/gamma-2 (1334 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRG2 Tclin GABA-A receptor; alpha-2/beta-3/gamma-2 (949 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRG2 Tclin GABA-A receptor; alpha-6/beta-3/gamma-2 (367 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRR2 Tchem GABA-C receptor (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRB2 Tclin GABA A receptor alpha-2/beta-2/gamma-2 (194 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRB2 Tclin GABA A receptor alpha-3/beta-2/gamma-2 (101 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
nfo Endonuclease 4 (425 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabrp GABA-A receptor; anion channel (5731 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabrg2 GABA-A receptor; alpha-1/beta-2/gamma-2 (554 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc6a11 GABA transporter (190 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488179794
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179794
IUPAC Name piperidine-4-carboxylic acid
INCHI InChI=1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9)
InChi Key SRJOCJYGOFTFLH-UHFFFAOYSA-N
Canonical SMILES C1CNCCC1C(=O)O
Isomeric SMILES C1CNCCC1C(=O)O
WGK Germany 3
RTECS NS5150000
PubChem CID 3773
Molecular Weight 129.16
Beilstein 112553
Reaxy-Rn 112553

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDateItem
G2429261Certificate of AnalysisJun 27, 2024 I109586
G2429262Certificate of AnalysisJun 27, 2024 I109586
L1910188Certificate of AnalysisSep 08, 2023 I109586
H1823120Certificate of AnalysisJun 23, 2022 I109586
H1823121Certificate of AnalysisJun 22, 2022 I109586
E2227249Certificate of AnalysisMar 22, 2022 I109586
E2227294Certificate of AnalysisMar 22, 2022 I109586
E2227298Certificate of AnalysisMar 22, 2022 I109586
E2227299Certificate of AnalysisMar 22, 2022 I109586
F2411072Certificate of AnalysisMar 22, 2022 I109586

Chemical and Physical Properties

SolubilitySolubility in Water:very faint turbidity
SensitivityLight sensitive.
Melt Point(°C)300°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS NS5150000
Reaxy-Rn 112553
Merck Index 5189

Related Documents

Citations of This Product

1. Junjian Xie, Jun Zhang, Xiaoyu Wang, Jiawei Xie, Bo Yang, Yuxuan Liang, Ji-Jun Zou, Qiuyu Zhang.  (2024)  Synthesis of JP-10 analogues high-density fuels via one-pot Diels-Alder/hydrodeoxygenation reaction.  FUEL,  361  (130738).  [PMID:] [10.1016/j.fuel.2023.130738]
2. Xianwei Li, Zhenqian Wu, Xudong Ma, Ling Xin, Xiao Yu, Yong Liu.  (2023)  MOF-derived crystalline carbon with graphite-like crystal: A high initial coulombic efficiency, low potential and large capacity anode for Na-ion batteries.  CARBON,  208  (10).  [PMID:] [10.1016/j.carbon.2023.03.020]
3. Junjian Xie, Yuxuan Liang, Bo Yang, Jun Zhang, Jiawei Xie, Ji-Jun Zou, Qiuyu Zhang.  (2023)  Photosensitized Conia reaction directed synthesis of high-performance asymmetric polycyclic hydrocarbons from biomass-derived ketones and petroleum-derived norbornene.  FUEL,  340  (127539).  [PMID:] [10.1016/j.fuel.2023.127539]
4. Dafu Cao, Fei Yang, Weibing Sheng, Yufeng Zhou, Xixing Zhou, Yaguang Lu, Fengmin Nie, Nanwen Li, Li Pan, Yuesheng Li.  (2022)  Polynorbornene-based anion exchange membranes with hydrophobic large steric hindrance arylene substituent.  JOURNAL OF MEMBRANE SCIENCE,  641  (119938).  [PMID:] [10.1016/j.memsci.2021.119938]
5. Junjie Zhou, Ning Li, Jialu Shen, Xu Meng, Xiang Liu.  (2021)  Palladium on carbon as an efficient, durable and economical catalyst for the alcoholysis of B2pin2.  INORGANIC CHEMISTRY COMMUNICATIONS,  130  (108732).  [PMID:] [10.1016/j.inoche.2021.108732]
6. Zhou Junjie, Huang Yu, Shen Jialu, Liu Xiang.  (2021)  Pd/C-Catalyzed H2 Evolution from Tetrahydroxydiboron Hydrolysis.  CATALYSIS LETTERS,  151  (10): (3004-3010).  [PMID:] [10.1007/s10562-021-03547-2]
7. Yingpeng Huo, Jiwen Hu, Yuanyuan Tu, Zhenzhu Huang, Shudong Lin, Yangfei Hu, Chao Feng.  (2020)  Platinum-Imidazolyl Schiff Base Complexes Immobilized in Periodic Mesoporous Organosilica Frameworks as Catalysts for Hydrosilylation.  APPLIED ORGANOMETALLIC CHEMISTRY,  34  (8): (e5697).  [PMID:] [10.1002/aoc.5697]
8. Junjian Xie, Xiangwen Zhang, Chengxiang Shi, Lun Pan, Fang Hou, Genkuo Nie, Jiawei Xie, Qing Liu, Ji-Jun Zou.  (2020)  Self-photosensitized [2 + 2] cycloaddition for synthesis of high-energy-density fuels.  Sustainable Energy & Fuels,  (2): (911-920).  [PMID:] [10.1039/C9SE00863B]

References

1. Phedias Diamandis,Jan Wildenhain,Ian D Clarke,Adrian G Sacher,Jeremy Graham,David S Bellows,Erick K M Ling,Ryan J Ward,Leanne G Jamieson,Mike Tyers,Peter B Dirks.  (2007-04-10)  Chemical genetics reveals a complex functional ground state of neural stem cells..  Nature chemical biology,  ((5)): (268-273).  [PMID:17417631]
2. Jing Yuan,Ronald L Johnson,Ruili Huang,Jennifer Wichterman,Hongying Jiang,Karen Hayton,David A Fidock,Thomas E Wellems,James Inglese,Christopher P Austin,Xin-zhuan Su.  (2009-09-08)  Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum..  Nature chemical biology,  ((10)): (765-771).  [PMID:19734910]
3. Iris Thondorf,Valerie Voigt,Sarah Schäfer,Sabine Gebauer,Katja Zebisch,Linda Laug,Matthias Brandsch.  (2011-10-01)  Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1)..  Bioorganic & medicinal chemistry,  19  ((21)): (6409-6418).  [PMID:21955456]
4. Michela Semeraro,Maurizio Muraca,Giulio Catesini,Rita Inglese,Francesca Iacovone,Gloria Maria Barraco,Melania Manco,Sara Boenzi,Carlo Dionisi-Vici,Cristiano Rizzo.  (2014-12-03)  Determination of plasma pipecolic acid by an easy and rapid liquid chromatography-tandem mass spectrometry method..  Clinica chimica acta; international journal of clinical chemistry,  440  (108-112).  [PMID:25447702]
5. Alicja Nowaczyk,Łukasz Fijałkowski,Paula Zaręba,Kinga Sałat.  (2018-09-17)  Docking and pharmacodynamic studies on hGAT1 inhibition activity in the presence of selected neuronal and astrocytic inhibitors. Part I..  Journal of molecular graphics & modelling,  85  (171-181).  [PMID:30219588]
6. Jenna Elizabeth Hunt,Anna Billeschou,Johanne Agerlin Windeløv,Bolette Hartmann,Christoph Ullmer,Jens Juul Holst,Hannelouise Kissow.  (2020-04-21)  Pharmacological activation of TGR5 promotes intestinal growth via a GLP-2-dependent pathway in mice..  American journal of physiology. Gastrointestinal and liver physiology,  318  ((5)): (G980-G987).  [PMID:32308039]
7. Junjian Xie, Jun Zhang, Xiaoyu Wang, Jiawei Xie, Bo Yang, Yuxuan Liang, Ji-Jun Zou, Qiuyu Zhang.  (2024)  Synthesis of JP-10 analogues high-density fuels via one-pot Diels-Alder/hydrodeoxygenation reaction.  FUEL,  361  (130738).  [PMID:] [10.1016/j.fuel.2023.130738]
8. Xianwei Li, Zhenqian Wu, Xudong Ma, Ling Xin, Xiao Yu, Yong Liu.  (2023)  MOF-derived crystalline carbon with graphite-like crystal: A high initial coulombic efficiency, low potential and large capacity anode for Na-ion batteries.  CARBON,  208  (10).  [PMID:] [10.1016/j.carbon.2023.03.020]
9. Junjian Xie, Yuxuan Liang, Bo Yang, Jun Zhang, Jiawei Xie, Ji-Jun Zou, Qiuyu Zhang.  (2023)  Photosensitized Conia reaction directed synthesis of high-performance asymmetric polycyclic hydrocarbons from biomass-derived ketones and petroleum-derived norbornene.  FUEL,  340  (127539).  [PMID:] [10.1016/j.fuel.2023.127539]
10. Dafu Cao, Fei Yang, Weibing Sheng, Yufeng Zhou, Xixing Zhou, Yaguang Lu, Fengmin Nie, Nanwen Li, Li Pan, Yuesheng Li.  (2022)  Polynorbornene-based anion exchange membranes with hydrophobic large steric hindrance arylene substituent.  JOURNAL OF MEMBRANE SCIENCE,  641  (119938).  [PMID:] [10.1016/j.memsci.2021.119938]
11. Junjie Zhou, Ning Li, Jialu Shen, Xu Meng, Xiang Liu.  (2021)  Palladium on carbon as an efficient, durable and economical catalyst for the alcoholysis of B2pin2.  INORGANIC CHEMISTRY COMMUNICATIONS,  130  (108732).  [PMID:] [10.1016/j.inoche.2021.108732]
12. Zhou Junjie, Huang Yu, Shen Jialu, Liu Xiang.  (2021)  Pd/C-Catalyzed H2 Evolution from Tetrahydroxydiboron Hydrolysis.  CATALYSIS LETTERS,  151  (10): (3004-3010).  [PMID:] [10.1007/s10562-021-03547-2]
13. Yingpeng Huo, Jiwen Hu, Yuanyuan Tu, Zhenzhu Huang, Shudong Lin, Yangfei Hu, Chao Feng.  (2020)  Platinum-Imidazolyl Schiff Base Complexes Immobilized in Periodic Mesoporous Organosilica Frameworks as Catalysts for Hydrosilylation.  APPLIED ORGANOMETALLIC CHEMISTRY,  34  (8): (e5697).  [PMID:] [10.1002/aoc.5697]
14. Junjian Xie, Xiangwen Zhang, Chengxiang Shi, Lun Pan, Fang Hou, Genkuo Nie, Jiawei Xie, Qing Liu, Ji-Jun Zou.  (2020)  Self-photosensitized [2 + 2] cycloaddition for synthesis of high-energy-density fuels.  Sustainable Energy & Fuels,  (2): (911-920).  [PMID:] [10.1039/C9SE00863B]

Solution Calculators