Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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I109586-10g | 10g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $15.90 | |
I109586-100g | 100g | In stock | $45.90 | |
I109586-250g | 250g | In stock | $102.90 | |
I109586-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $133.90 |
Synonyms | Acide piperidine-carboxylique-4 | EINECS 207-872-3 | Isonipecotic acid | iso-nipecotic acid | NCGC00015573-03 | SR-01000075617-1 | EN300-19594 | Acide isonipecotique | NCGC00015573-05 | s5612 | 4-Piperidinecarboxylic acid | SDCCGSBI-0050683.P002 | HY-Y117 |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Protected from light |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | AGONIST, ANTAGONIST |
Mechanism of action | Agonist of GABA A receptor α1 subunit;Agonist of GABA A receptor α2 subunit;Agonist of GABA A receptor α3 subunit;Agonist of GABA A receptor α4 subunit;Agonist of GABA A receptor α5 subunit;Agonist of GABA A receptor α6 subunit;Antagonist of GABA A recept |
Note | 5g、25g卖完停产,不再备货 |
Product Description | Isonipecotic acid is an important reactant for the synthesis of alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors. It is also used in the synthesis of antibiotic nitroxoline derivatives for cathepsin B inhibition. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488179794 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179794 |
IUPAC Name | piperidine-4-carboxylic acid |
INCHI | InChI=1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9) |
InChi Key | SRJOCJYGOFTFLH-UHFFFAOYSA-N |
Canonical SMILES | C1CNCCC1C(=O)O |
Isomeric SMILES | C1CNCCC1C(=O)O |
WGK Germany | 3 |
RTECS | NS5150000 |
PubChem CID | 3773 |
Molecular Weight | 129.16 |
Beilstein | 112553 |
Reaxy-Rn | 112553 |
PubChem CID | 3773 |
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ChEMBL Ligand | CHEMBL279998 |
CAS Registry No. | 498-94-2 |
Wikipedia | Isonipecotic_acid |
RCSB PDB Ligand | MN1 |
PubChem SID | 488179794 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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G2429261 | Certificate of Analysis | Jun 27, 2024 | I109586 |
G2429262 | Certificate of Analysis | Jun 27, 2024 | I109586 |
L1910188 | Certificate of Analysis | Sep 08, 2023 | I109586 |
H1823120 | Certificate of Analysis | Jun 23, 2022 | I109586 |
H1823121 | Certificate of Analysis | Jun 22, 2022 | I109586 |
E2227249 | Certificate of Analysis | Mar 22, 2022 | I109586 |
E2227294 | Certificate of Analysis | Mar 22, 2022 | I109586 |
E2227298 | Certificate of Analysis | Mar 22, 2022 | I109586 |
E2227299 | Certificate of Analysis | Mar 22, 2022 | I109586 |
F2411072 | Certificate of Analysis | Mar 22, 2022 | I109586 |
Solubility | Solubility in Water:very faint turbidity |
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Sensitivity | Light sensitive. |
Melt Point(°C) | 300°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | NS5150000 |
Reaxy-Rn | 112553 |
Merck Index | 5189 |
1. Junjian Xie, Jun Zhang, Xiaoyu Wang, Jiawei Xie, Bo Yang, Yuxuan Liang, Ji-Jun Zou, Qiuyu Zhang. (2024) Synthesis of JP-10 analogues high-density fuels via one-pot Diels-Alder/hydrodeoxygenation reaction. FUEL, 361 (130738). [PMID:] [10.1016/j.fuel.2023.130738] |
2. Xianwei Li, Zhenqian Wu, Xudong Ma, Ling Xin, Xiao Yu, Yong Liu. (2023) MOF-derived crystalline carbon with graphite-like crystal: A high initial coulombic efficiency, low potential and large capacity anode for Na-ion batteries. CARBON, 208 (10). [PMID:] [10.1016/j.carbon.2023.03.020] |
3. Junjian Xie, Yuxuan Liang, Bo Yang, Jun Zhang, Jiawei Xie, Ji-Jun Zou, Qiuyu Zhang. (2023) Photosensitized Conia reaction directed synthesis of high-performance asymmetric polycyclic hydrocarbons from biomass-derived ketones and petroleum-derived norbornene. FUEL, 340 (127539). [PMID:] [10.1016/j.fuel.2023.127539] |
4. Dafu Cao, Fei Yang, Weibing Sheng, Yufeng Zhou, Xixing Zhou, Yaguang Lu, Fengmin Nie, Nanwen Li, Li Pan, Yuesheng Li. (2022) Polynorbornene-based anion exchange membranes with hydrophobic large steric hindrance arylene substituent. JOURNAL OF MEMBRANE SCIENCE, 641 (119938). [PMID:] [10.1016/j.memsci.2021.119938] |
5. Junjie Zhou, Ning Li, Jialu Shen, Xu Meng, Xiang Liu. (2021) Palladium on carbon as an efficient, durable and economical catalyst for the alcoholysis of B2pin2. INORGANIC CHEMISTRY COMMUNICATIONS, 130 (108732). [PMID:] [10.1016/j.inoche.2021.108732] |
6. Zhou Junjie, Huang Yu, Shen Jialu, Liu Xiang. (2021) Pd/C-Catalyzed H2 Evolution from Tetrahydroxydiboron Hydrolysis. CATALYSIS LETTERS, 151 (10): (3004-3010). [PMID:] [10.1007/s10562-021-03547-2] |
7. Yingpeng Huo, Jiwen Hu, Yuanyuan Tu, Zhenzhu Huang, Shudong Lin, Yangfei Hu, Chao Feng. (2020) Platinum-Imidazolyl Schiff Base Complexes Immobilized in Periodic Mesoporous Organosilica Frameworks as Catalysts for Hydrosilylation. APPLIED ORGANOMETALLIC CHEMISTRY, 34 (8): (e5697). [PMID:] [10.1002/aoc.5697] |
8. Junjian Xie, Xiangwen Zhang, Chengxiang Shi, Lun Pan, Fang Hou, Genkuo Nie, Jiawei Xie, Qing Liu, Ji-Jun Zou. (2020) Self-photosensitized [2 + 2] cycloaddition for synthesis of high-energy-density fuels. Sustainable Energy & Fuels, 4 (2): (911-920). [PMID:] [10.1039/C9SE00863B] |
1. Phedias Diamandis,Jan Wildenhain,Ian D Clarke,Adrian G Sacher,Jeremy Graham,David S Bellows,Erick K M Ling,Ryan J Ward,Leanne G Jamieson,Mike Tyers,Peter B Dirks. (2007-04-10) Chemical genetics reveals a complex functional ground state of neural stem cells.. Nature chemical biology, 3 ((5)): (268-273). [PMID:17417631] |
2. Jing Yuan,Ronald L Johnson,Ruili Huang,Jennifer Wichterman,Hongying Jiang,Karen Hayton,David A Fidock,Thomas E Wellems,James Inglese,Christopher P Austin,Xin-zhuan Su. (2009-09-08) Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.. Nature chemical biology, 5 ((10)): (765-771). [PMID:19734910] |
3. Iris Thondorf,Valerie Voigt,Sarah Schäfer,Sabine Gebauer,Katja Zebisch,Linda Laug,Matthias Brandsch. (2011-10-01) Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).. Bioorganic & medicinal chemistry, 19 ((21)): (6409-6418). [PMID:21955456] |
4. Michela Semeraro,Maurizio Muraca,Giulio Catesini,Rita Inglese,Francesca Iacovone,Gloria Maria Barraco,Melania Manco,Sara Boenzi,Carlo Dionisi-Vici,Cristiano Rizzo. (2014-12-03) Determination of plasma pipecolic acid by an easy and rapid liquid chromatography-tandem mass spectrometry method.. Clinica chimica acta; international journal of clinical chemistry, 440 (108-112). [PMID:25447702] |
5. Alicja Nowaczyk,Łukasz Fijałkowski,Paula Zaręba,Kinga Sałat. (2018-09-17) Docking and pharmacodynamic studies on hGAT1 inhibition activity in the presence of selected neuronal and astrocytic inhibitors. Part I.. Journal of molecular graphics & modelling, 85 (171-181). [PMID:30219588] |
6. Jenna Elizabeth Hunt,Anna Billeschou,Johanne Agerlin Windeløv,Bolette Hartmann,Christoph Ullmer,Jens Juul Holst,Hannelouise Kissow. (2020-04-21) Pharmacological activation of TGR5 promotes intestinal growth via a GLP-2-dependent pathway in mice.. American journal of physiology. Gastrointestinal and liver physiology, 318 ((5)): (G980-G987). [PMID:32308039] |
7. Junjian Xie, Jun Zhang, Xiaoyu Wang, Jiawei Xie, Bo Yang, Yuxuan Liang, Ji-Jun Zou, Qiuyu Zhang. (2024) Synthesis of JP-10 analogues high-density fuels via one-pot Diels-Alder/hydrodeoxygenation reaction. FUEL, 361 (130738). [PMID:] [10.1016/j.fuel.2023.130738] |
8. Xianwei Li, Zhenqian Wu, Xudong Ma, Ling Xin, Xiao Yu, Yong Liu. (2023) MOF-derived crystalline carbon with graphite-like crystal: A high initial coulombic efficiency, low potential and large capacity anode for Na-ion batteries. CARBON, 208 (10). [PMID:] [10.1016/j.carbon.2023.03.020] |
9. Junjian Xie, Yuxuan Liang, Bo Yang, Jun Zhang, Jiawei Xie, Ji-Jun Zou, Qiuyu Zhang. (2023) Photosensitized Conia reaction directed synthesis of high-performance asymmetric polycyclic hydrocarbons from biomass-derived ketones and petroleum-derived norbornene. FUEL, 340 (127539). [PMID:] [10.1016/j.fuel.2023.127539] |
10. Dafu Cao, Fei Yang, Weibing Sheng, Yufeng Zhou, Xixing Zhou, Yaguang Lu, Fengmin Nie, Nanwen Li, Li Pan, Yuesheng Li. (2022) Polynorbornene-based anion exchange membranes with hydrophobic large steric hindrance arylene substituent. JOURNAL OF MEMBRANE SCIENCE, 641 (119938). [PMID:] [10.1016/j.memsci.2021.119938] |
11. Junjie Zhou, Ning Li, Jialu Shen, Xu Meng, Xiang Liu. (2021) Palladium on carbon as an efficient, durable and economical catalyst for the alcoholysis of B2pin2. INORGANIC CHEMISTRY COMMUNICATIONS, 130 (108732). [PMID:] [10.1016/j.inoche.2021.108732] |
12. Zhou Junjie, Huang Yu, Shen Jialu, Liu Xiang. (2021) Pd/C-Catalyzed H2 Evolution from Tetrahydroxydiboron Hydrolysis. CATALYSIS LETTERS, 151 (10): (3004-3010). [PMID:] [10.1007/s10562-021-03547-2] |
13. Yingpeng Huo, Jiwen Hu, Yuanyuan Tu, Zhenzhu Huang, Shudong Lin, Yangfei Hu, Chao Feng. (2020) Platinum-Imidazolyl Schiff Base Complexes Immobilized in Periodic Mesoporous Organosilica Frameworks as Catalysts for Hydrosilylation. APPLIED ORGANOMETALLIC CHEMISTRY, 34 (8): (e5697). [PMID:] [10.1002/aoc.5697] |
14. Junjian Xie, Xiangwen Zhang, Chengxiang Shi, Lun Pan, Fang Hou, Genkuo Nie, Jiawei Xie, Qing Liu, Ji-Jun Zou. (2020) Self-photosensitized [2 + 2] cycloaddition for synthesis of high-energy-density fuels. Sustainable Energy & Fuels, 4 (2): (911-920). [PMID:] [10.1039/C9SE00863B] |