Grouped product items

SKU

Size

Availability

Price

Qty

I109586-10g

10g

Available within 8-12 weeks(?)

$15.90

I109586-100g

100g

In stock

$45.90

I109586-250g

250g

In stock

$102.90

I109586-500g

500g

Available within 4-8 weeks(?)

$133.90

Basic Description

Synonyms	Isonipecotic acid\|Piperidine-4-carboxylic acid\|498-94-2\|4-Piperidinecarboxylic acid\|4-Carboxypiperidine\|Hexahydroisonicotinic acid\|h-inp-oh\|Isonicotinic acid, hexahydro-\|MFCD00006004\|Acide isonipecotique\|4-Hexahydroisonicotinic acid\|dl-isopipecolinic acid
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Protected from light
Shipped In	Normal
Grade	Moligand™
Action Type	AGONIST, ANTAGONIST
Mechanism of action	Agonist of GABA A receptor α1 subunit;Agonist of GABA A receptor α2 subunit;Agonist of GABA A receptor α3 subunit;Agonist of GABA A receptor α4 subunit;Agonist of GABA A receptor α5 subunit;Agonist of GABA A receptor α6 subunit;Antagonist of GABA A recept
Note	5g、25g卖完停产，不再备货
Product Description	Isonipecotic acid is an important reactant for the synthesis of alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors. It is also used in the synthesis of antibiotic nitroxoline derivatives for cathepsin B inhibition. A HDAC inhibitor.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRR1 Tchem Gamma-aminobutyric acid receptor subunit rho-1 0 Activities

Discover Target: GABRR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRR3 Tbio Gamma-aminobutyric acid receptor subunit rho-3 0 Activities

Discover Target: GABRR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

Discover Target: GABRA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Discover Target: EHMT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRG2 Tclin Gamma-aminobutyric acid receptor subunit gamma-2 0 Activities

Discover Target: GABRG2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA3 Tclin Gamma-aminobutyric acid receptor subunit alpha-3 0 Activities

Discover Target: GABRA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA4 Tclin Gamma-aminobutyric acid receptor subunit alpha-4 0 Activities

Discover Target: GABRA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA5 Tclin Gamma-aminobutyric acid receptor subunit alpha-5 0 Activities

Discover Target: GABRA5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRR2 Tchem Gamma-aminobutyric acid receptor subunit rho-2 0 Activities

Discover Target: GABRR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA2 Tclin Gamma-aminobutyric acid receptor subunit alpha-2 0 Activities

Discover Target: GABRA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA6 Tclin Gamma-aminobutyric acid receptor subunit alpha-6 0 Activities

Discover Target: GABRA6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC36A1 Tchem Proton-coupled amino acid transporter 1 0 Activities

Discover Target: SLC36A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FTL Tbio Ferritin light chain 0 Activities

Discover Target: FTL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

Discover Target: TXNRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A13 Tchem Sodium- and chloride-dependent GABA transporter 2 0 Activities

Discover Target: SLC6A13

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TSHR Tclin Thyrotropin receptor 0 Activities

Discover Target: TSHR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PMP22 Tbio Peripheral myelin protein 22 0 Activities

Discover Target: PMP22

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Discover Target: APEX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

Discover Target: CHRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ARSA Tbio Arylsulfatase A 0 Activities

Discover Target: ARSA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 0 Activities

Discover Target: GRIN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488179794
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179794
IUPAC Name	piperidine-4-carboxylic acid
INCHI	InChI=1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9)
InChi Key	SRJOCJYGOFTFLH-UHFFFAOYSA-N
Canonical SMILES	C1CNCCC1C(=O)O
Isomeric SMILES	C1CNCCC1C(=O)O
WGK Germany	3
RTECS	NS5150000
PubChem CID	3773
Molecular Weight	129.16
Beilstein	112553
Reaxy-Rn	112553

Database links

PubChem CID	3773
ChEMBL Ligand	CHEMBL279998
CAS Registry No.	498-94-2
Wikipedia	Isonipecotic_acid
RCSB PDB Ligand	MN1
PubChem SID	488179794

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

10 results found

Lot Number	Certificate Type	Date	Item
G2429261	Certificate of Analysis	Jun 27, 2024	I109586
G2429262	Certificate of Analysis	Jun 27, 2024	I109586
L1910188	Certificate of Analysis	Sep 08, 2023	I109586
H1823120	Certificate of Analysis	Jun 23, 2022	I109586
H1823121	Certificate of Analysis	Jun 22, 2022	I109586
E2227249	Certificate of Analysis	Mar 22, 2022	I109586
E2227294	Certificate of Analysis	Mar 22, 2022	I109586
E2227298	Certificate of Analysis	Mar 22, 2022	I109586
E2227299	Certificate of Analysis	Mar 22, 2022	I109586
F2411072	Certificate of Analysis	Mar 22, 2022	I109586

Chemical and Physical Properties

Solubility	Solubility in Water：very faint turbidity
Sensitivity	Light sensitive.
Melt Point(°C)	300°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	NS5150000
Reaxy-Rn	112553
Merck Index	5189

References

1. Phedias Diamandis,Jan Wildenhain,Ian D Clarke,Adrian G Sacher,Jeremy Graham,David S Bellows,Erick K M Ling,Ryan J Ward,Leanne G Jamieson,Mike Tyers,Peter B Dirks. (2007-04-10) Chemical genetics reveals a complex functional ground state of neural stem cells.. Nature chemical biology, 3 ((5)): (268-273). [PMID:17417631]
2. Jing Yuan,Ronald L Johnson,Ruili Huang,Jennifer Wichterman,Hongying Jiang,Karen Hayton,David A Fidock,Thomas E Wellems,James Inglese,Christopher P Austin,Xin-zhuan Su. (2009-09-08) Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.. Nature chemical biology, 5 ((10)): (765-771). [PMID:19734910]
3. Iris Thondorf,Valerie Voigt,Sarah Schäfer,Sabine Gebauer,Katja Zebisch,Linda Laug,Matthias Brandsch. (2011-10-01) Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).. Bioorganic & medicinal chemistry, 19 ((21)): (6409-6418). [PMID:21955456]
4. Michela Semeraro,Maurizio Muraca,Giulio Catesini,Rita Inglese,Francesca Iacovone,Gloria Maria Barraco,Melania Manco,Sara Boenzi,Carlo Dionisi-Vici,Cristiano Rizzo. (2014-12-03) Determination of plasma pipecolic acid by an easy and rapid liquid chromatography-tandem mass spectrometry method.. Clinica chimica acta; international journal of clinical chemistry, 440 (108-112). [PMID:25447702]
5. Alicja Nowaczyk,Łukasz Fijałkowski,Paula Zaręba,Kinga Sałat. (2018-09-17) Docking and pharmacodynamic studies on hGAT1 inhibition activity in the presence of selected neuronal and astrocytic inhibitors. Part I.. Journal of molecular graphics & modelling, 85 (171-181). [PMID:30219588]
6. Jenna Elizabeth Hunt,Anna Billeschou,Johanne Agerlin Windeløv,Bolette Hartmann,Christoph Ullmer,Jens Juul Holst,Hannelouise Kissow. (2020-04-21) Pharmacological activation of TGR5 promotes intestinal growth via a GLP-2-dependent pathway in mice.. American journal of physiology. Gastrointestinal and liver physiology, 318 ((5)): (G980-G987). [PMID:32308039]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.