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isoquinoline 17 , CAS No.I611187, kelch like ECH-associated protein 1

Item Number
I611187
Grouped product items
SKUSizeAvailabilityPrice Qty
I611187-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$570.90
I611187-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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kelch like ECH-associated protein 1

Basic Description

Specifications & PurityMoligand™
GradeMoligand™
Mechanism of actionkelch like ECH-associated protein 1

Associated Targets(Human)

KEAP1 Tclin Kelch-like ECH-associated protein 1 (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HaCaT (4069 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KEAP1 Tclin Kelch-like ECH-associated protein 1 (1736 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Salmonella typhimurium (15756 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-(N-{4-[N-(carboxymethyl)4-methoxybenzenesulfonamido]isoquinolin-1-yl}4-methoxybenzenesulfonamido)acetic acid
INCHI InChI=1S/C27H25N3O10S2/c1-39-18-7-11-20(12-8-18)41(35,36)29(16-25(31)32)24-15-28-27(23-6-4-3-5-22(23)24)30(17-26(33)34)42(37,38)21-13-9-19(40-2)10-14-21/h3-15H,16-17H2,1-2H3,(H,31,32)(H,33,34)
InChi Key SDNGUWKKARNBMG-UHFFFAOYSA-N
Canonical SMILES COc1ccc(cc1)S(=O)(=O)N(c1ncc(c2c1cccc2)N(S(=O)(=O)c1ccc(cc1)OC)CC(=O)O)CC(=O)O
Isomeric SMILES COC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)O)C2=CN=C(C3=CC=CC=C32)N(CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)OC
PubChem CID 134813907

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Wells G.  (2015)  Peptide and small molecule inhibitors of the Keap1-Nrf2 protein-protein interaction..  Biochem Soc Trans,  43  (4): (674-9).  [PMID:26551711] [10.1021/op500134e]
2. Richardson BG, Jain AD, Potteti HR, Lazzara PR, David BP, Tamatam CR, Choma E, Skowron K, Dye K, Siddiqui Z et al..  (2018)  Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors..  J Med Chem,  61  (17): (8029-8047).  [PMID:30122040] [10.1021/op500134e]

Solution Calculators

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